STRINGSTRING
IL1B IL1B PLA2G5 PLA2G5 COLEC10 COLEC10 F2RL1 F2RL1 G3QW50_GORGO G3QW50_GORGO CD47 CD47 NCKAP1L NCKAP1L CFP CFP SFTPD SFTPD NOD2 NOD2 G3R6K5_GORGO G3R6K5_GORGO SIRPD SIRPD LYAR LYAR APPL2 APPL2 SLC11A1 SLC11A1 CD300LF CD300LF RAB27A RAB27A MFGE8 MFGE8 G3RFF0_GORGO G3RFF0_GORGO TREM2 TREM2 PTX3 PTX3 CALR CALR CCL2 CCL2 CAMK1D CAMK1D PYCARD PYCARD G3RMN5_GORGO G3RMN5_GORGO FCER1G FCER1G G3RPZ9_GORGO G3RPZ9_GORGO G3RR23_GORGO G3RR23_GORGO G3RRK1_GORGO G3RRK1_GORGO MASP2 MASP2 G3RV54_GORGO G3RV54_GORGO SIRPA SIRPA G3S2M4_GORGO G3S2M4_GORGO DNM2 DNM2 FCGR2B FCGR2B C3 C3 BTK BTK G3SCX7_GORGO G3SCX7_GORGO LMAN2 LMAN2 SIRPG SIRPG RAB31 RAB31 FCN2 FCN2 PLCG2 PLCG2 ENSGGOP00000036972 ENSGGOP00000036972 COLEC11 COLEC11 MYO18A MYO18A MBL2 MBL2 G3SKN5_GORGO G3SKN5_GORGO IL15 IL15 MERTK MERTK SOD1 SOD1 ENSGGOP00000044488 ENSGGOP00000044488 PTPRJ PTPRJ ENSGGOP00000045489 ENSGGOP00000045489 AHSG AHSG ANO6 ANO6 ENSGGOP00000051997 ENSGGOP00000051997 IL15RA IL15RA APOA2 APOA2 PPARG PPARG APOA1 APOA1 FCGR1A FCGR1A G3QF49_GORGO G3QF49_GORGO MASP1 MASP1 ITGA2 ITGA2 TULP1 TULP1 IL2RB IL2RB G3QMH2_GORGO G3QMH2_GORGO FPR2 FPR2 G3QT76_GORGO G3QT76_GORGO FCN3 FCN3 TUB TUB STAP1 STAP1 CD36 CD36 GATA2 GATA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PLA2G5Phospholipase A(2). (138 aa)
COLEC10Collectin subfamily member 10. (277 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
G3QW50_GORGOBCR activator of RhoGEF and GTPase. (1101 aa)
CD47CD47 molecule. (323 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
CFPComplement factor properdin. (469 aa)
SFTPDSurfactant protein D. (375 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
G3R6K5_GORGOATP binding cassette subfamily A member 7. (2132 aa)
SIRPDSignal regulatory protein delta. (197 aa)
LYARLy1 antibody reactive. (379 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
CD300LFCD300 molecule like family member f. (305 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
G3RFF0_GORGOFibronectin type-III domain-containing protein. (369 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
PTX3Pentraxin 3. (381 aa)
CALRCalreticulin. (417 aa)
CCL2C-C motif chemokine. (99 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
PYCARDPYD and CARD domain containing. (195 aa)
G3RMN5_GORGOUncharacterized protein. (383 aa)
FCER1GUncharacterized protein. (112 aa)
G3RPZ9_GORGOAnaphylatoxin-like domain-containing protein. (1528 aa)
G3RR23_GORGOUncharacterized protein. (210 aa)
G3RRK1_GORGOUncharacterized protein. (497 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
G3RV54_GORGOProtein tyrosine phosphatase receptor type C. (1306 aa)
SIRPASignal regulatory protein alpha. (508 aa)
G3S2M4_GORGOUncharacterized protein. (278 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
FCGR2BUncharacterized protein. (310 aa)
C3Complement C3. (1663 aa)
BTKTyrosine-protein kinase. (693 aa)
G3SCX7_GORGOGrowth arrest specific 6. (679 aa)
LMAN2L-type lectin-like domain-containing protein. (356 aa)
SIRPGSignal regulatory protein gamma. (354 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
FCN2Ficolin 2. (313 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSGGOP00000036972Uncharacterized protein. (78 aa)
COLEC11Collectin subfamily member 11. (285 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (248 aa)
G3SKN5_GORGODedicator of cytokinesis 2; Belongs to the DOCK family. (1698 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MERTKMER proto-oncogene, tyrosine kinase. (970 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ENSGGOP00000044488Uncharacterized protein. (1750 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1305 aa)
ENSGGOP00000045489Ig-like domain-containing protein. (164 aa)
AHSGAlpha 2-HS glycoprotein. (367 aa)
ANO6Anoctamin. (921 aa)
ENSGGOP00000051997C-type lectin domain containing 7A. (247 aa)
IL15RASushi domain-containing protein. (323 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (133 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
FCGR1AUncharacterized protein. (374 aa)
G3QF49_GORGOAzurocidin 1. (251 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (728 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (542 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
G3QMH2_GORGOL-type lectin-like domain-containing protein. (243 aa)
FPR2N-formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (By similarity). Binding of FMLP to the receptor causes activation of neutrophils (By similarity). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5- stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). (350 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FCN3Ficolin 3. (299 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
GATA2GATA binding protein 2. (480 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (14%) [HD]