STRINGSTRING
IL17A IL17A AQP1 AQP1 DEFA4 DEFA4 DEFA6 DEFA6 LYZ LYZ ADM ADM DEFB1 DEFB1 PRKD1 PRKD1 MPEG1 MPEG1 CAMP CAMP DEFB128 DEFB128 PRH2 PRH2 SLC11A1 SLC11A1 G3RD46_GORGO G3RD46_GORGO GALP GALP CALCA CALCA TREM2 TREM2 RPS19 RPS19 DEFA5 DEFA5 PYCARD PYCARD NLRP10 NLRP10 DCD DCD LTF LTF G3QX51_GORGO G3QX51_GORGO G3QX42_GORGO G3QX42_GORGO SERPINE1 SERPINE1 TUSC2 TUSC2 F2 F2 G3QV30_GORGO G3QV30_GORGO G3QUU9_GORGO G3QUU9_GORGO IL23R IL23R G3QRK3_GORGO G3QRK3_GORGO IL17F IL17F DEFA1B DEFA1B IL22RA1 IL22RA1 IL12B IL12B RNASE3 RNASE3 DEFB136 DEFB136 SSC5D SSC5D CD4 CD4 LCE3B LCE3B IL23A IL23A SELP SELP G3QF49_GORGO G3QF49_GORGO IL6R IL6R G3QER9_GORGO G3QER9_GORGO HAMP HAMP G3QEF1_GORGO G3QEF1_GORGO NOS2 NOS2 IL6 IL6 IRGM IRGM PRB4 PRB4 G3RWV9_GORGO G3RWV9_GORGO TLR4 TLR4 ENSGGOP00000021036 ENSGGOP00000021036 PRH1 PRH1 LYPD8 LYPD8 G3SBB4_GORGO G3SBB4_GORGO G3SBD9_GORGO G3SBD9_GORGO G3SDI2_GORGO G3SDI2_GORGO UMOD UMOD RNASE6 RNASE6 G3SIL0_GORGO G3SIL0_GORGO G3SJS6_GORGO G3SJS6_GORGO CHGA CHGA G3SK86_GORGO G3SK86_GORGO G3SK93_GORGO G3SK93_GORGO ENSGGOP00000031506 ENSGGOP00000031506 OPTN OPTN ENSGGOP00000037086 ENSGGOP00000037086 TSLP TSLP RNASE7 RNASE7 DEFB126 DEFB126 RPL30 RPL30 ENSGGOP00000041365 ENSGGOP00000041365 ENSGGOP00000041400 ENSGGOP00000041400 TNFRSF14 TNFRSF14 ENSGGOP00000043190 ENSGGOP00000043190 ENSGGOP00000046073 ENSGGOP00000046073 ENSGGOP00000046335 ENSGGOP00000046335 ROMO1 ROMO1 TAC1 TAC1 TREM1 TREM1 RARRES2 RARRES2 ENSGGOP00000048920 ENSGGOP00000048920 DEFB118 DEFB118
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17AInterleukin 17A. (155 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
DEFA4Defensin alpha 4. (97 aa)
DEFA6Defensin alpha 6. (100 aa)
LYZLysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents; Belongs to the glycosyl hydrolase 22 family. (148 aa)
ADMAdrenomedullin. (185 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
MPEG1Macrophage expressed 1. (716 aa)
CAMPCathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (92 aa)
PRH2Proline rich protein HaeIII subfamily 2. (149 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
G3RD46_GORGOCathepsin G; Belongs to the peptidase S1 family. (255 aa)
GALPGalanin like peptide. (116 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
RPS19Ribosomal protein S19. (145 aa)
DEFA5Defensin alpha 5. (94 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NLRP10NLR family pyrin domain containing 10. (661 aa)
DCDDermcidin. (120 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
G3QX42_GORGOBactericidal permeability increasing protein. (487 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
G3QV30_GORGOGasdermin D. (532 aa)
G3QUU9_GORGOProtein S100; Belongs to the S-100 family. (101 aa)
IL23RInterleukin 23 receptor. (629 aa)
G3QRK3_GORGOBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
IL17FInterleukin 17F. (163 aa)
DEFA1BDEFENSIN domain-containing protein. (94 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (574 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
RNASE3Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity). (160 aa)
DEFB136Defensin beta 136. (78 aa)
SSC5DUncharacterized protein. (941 aa)
CD4CD4 molecule. (458 aa)
LCE3BLate cornified envelope 3B. (95 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
SELPSelectin P. (830 aa)
G3QF49_GORGOAzurocidin 1. (251 aa)
IL6RInterleukin 6 receptor. (468 aa)
G3QER9_GORGOElastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
G3QEF1_GORGOUncharacterized protein. (282 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IL6Interleukin 6. (234 aa)
IRGMImmunity related GTPase M. (181 aa)
PRB4Uncharacterized protein. (156 aa)
G3RWV9_GORGOUncharacterized protein. (178 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
ENSGGOP00000021036annotation not available (839 aa)
PRH1Proline rich protein HaeIII subfamily 1. (189 aa)
LYPD8LY6/PLAUR domain containing 8. (237 aa)
G3SBB4_GORGORibosomal_L7Ae domain-containing protein. (133 aa)
G3SBD9_GORGODEFSN domain-containing protein. (55 aa)
G3SDI2_GORGOMajor histocompatibility complex, class I-related; Belongs to the MHC class I family. (341 aa)
UMODUromodulin. (690 aa)
RNASE6Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. (150 aa)
G3SIL0_GORGOAdhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1570 aa)
G3SJS6_GORGOBPI fold containing family C. (466 aa)
CHGAChromogranin A. (458 aa)
G3SK86_GORGOS100 calcium binding protein A7 like 2. (106 aa)
G3SK93_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSGGOP00000031506DEFENSIN domain-containing protein. (93 aa)
OPTNOptineurin. (577 aa)
ENSGGOP00000037086Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (72 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
RNASE7Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (111 aa)
RPL30Ribosomal_L7Ae domain-containing protein. (115 aa)
ENSGGOP00000041365Drosha ribonuclease III. (1380 aa)
ENSGGOP00000041400MACPF domain-containing protein. (686 aa)
TNFRSF14Uncharacterized protein. (193 aa)
ENSGGOP00000043190Uncharacterized protein. (234 aa)
ENSGGOP00000046073Protein S100; Belongs to the S-100 family. (101 aa)
ENSGGOP00000046335Uncharacterized protein. (118 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
TAC1Tachykinin precursor 1. (129 aa)
TREM1IG domain-containing protein. (249 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
ENSGGOP00000048920Ribosomal_L7Ae domain-containing protein. (93 aa)
DEFB118Beta-defensin 118; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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