STRINGSTRING
G3SBD9_GORGO G3SBD9_GORGO LYPD8 LYPD8 PRH1 PRH1 ENSGGOP00000021036 ENSGGOP00000021036 TLR4 TLR4 G3RWV9_GORGO G3RWV9_GORGO PRB4 PRB4 IRGM IRGM IL6 IL6 NOS2 NOS2 DEFB136 DEFB136 RNASE3 RNASE3 PYCARD PYCARD DEFA5 DEFA5 RPS19 RPS19 TREM2 TREM2 CALCA CALCA GALP GALP G3RD46_GORGO G3RD46_GORGO SLC11A1 SLC11A1 PRH2 PRH2 DEFB128 DEFB128 CAMP CAMP MPEG1 MPEG1 PRKD1 PRKD1 DEFB1 DEFB1 ADM ADM LYZ LYZ DEFA6 DEFA6 DEFA4 DEFA4 AQP1 AQP1 IL17A IL17A RARRES2 RARRES2 NLRP10 NLRP10 DCD DCD LTF LTF ENSGGOP00000048920 ENSGGOP00000048920 DEFB118 DEFB118 G3QEF1_GORGO G3QEF1_GORGO HAMP HAMP G3QER9_GORGO G3QER9_GORGO IL6R IL6R G3QF49_GORGO G3QF49_GORGO SELP SELP IL23A IL23A LCE3B LCE3B CD4 CD4 SSC5D SSC5D IL12B IL12B IL22RA1 IL22RA1 DEFA1B DEFA1B IL17F IL17F G3QRK3_GORGO G3QRK3_GORGO IL23R IL23R G3QUU9_GORGO G3QUU9_GORGO G3QV30_GORGO G3QV30_GORGO F2 F2 TUSC2 TUSC2 SERPINE1 SERPINE1 G3QX42_GORGO G3QX42_GORGO G3QX51_GORGO G3QX51_GORGO TREM1 TREM1 TAC1 TAC1 ROMO1 ROMO1 ENSGGOP00000046335 ENSGGOP00000046335 ENSGGOP00000046073 ENSGGOP00000046073 ENSGGOP00000043190 ENSGGOP00000043190 TNFRSF14 TNFRSF14 ENSGGOP00000041400 ENSGGOP00000041400 ENSGGOP00000041365 ENSGGOP00000041365 RPL30 RPL30 DEFB126 DEFB126 RNASE7 RNASE7 TSLP TSLP ENSGGOP00000037086 ENSGGOP00000037086 OPTN OPTN ENSGGOP00000031506 ENSGGOP00000031506 G3SK93_GORGO G3SK93_GORGO G3SK86_GORGO G3SK86_GORGO CHGA CHGA G3SJS6_GORGO G3SJS6_GORGO G3SIL0_GORGO G3SIL0_GORGO RNASE6 RNASE6 UMOD UMOD G3SDI2_GORGO G3SDI2_GORGO G3SBB4_GORGO G3SBB4_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3SBD9_GORGODEFSN domain-containing protein. (55 aa)
LYPD8LY6/PLAUR domain containing 8. (237 aa)
PRH1Proline rich protein HaeIII subfamily 1. (189 aa)
ENSGGOP00000021036annotation not available (839 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
G3RWV9_GORGOUncharacterized protein. (178 aa)
PRB4Uncharacterized protein. (156 aa)
IRGMImmunity related GTPase M. (181 aa)
IL6Interleukin 6. (234 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
DEFB136Defensin beta 136. (78 aa)
RNASE3Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity). (160 aa)
PYCARDPYD and CARD domain containing. (195 aa)
DEFA5Defensin alpha 5. (94 aa)
RPS19Ribosomal protein S19. (145 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
GALPGalanin like peptide. (116 aa)
G3RD46_GORGOCathepsin G; Belongs to the peptidase S1 family. (255 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
PRH2Proline rich protein HaeIII subfamily 2. (149 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (92 aa)
CAMPCathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
MPEG1Macrophage expressed 1. (716 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
ADMAdrenomedullin. (185 aa)
LYZLysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents; Belongs to the glycosyl hydrolase 22 family. (148 aa)
DEFA6Defensin alpha 6. (100 aa)
DEFA4Defensin alpha 4. (97 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
IL17AInterleukin 17A. (155 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
NLRP10NLR family pyrin domain containing 10. (661 aa)
DCDDermcidin. (120 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
ENSGGOP00000048920Ribosomal_L7Ae domain-containing protein. (93 aa)
DEFB118Beta-defensin 118; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
G3QEF1_GORGOUncharacterized protein. (282 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
G3QER9_GORGOElastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
IL6RInterleukin 6 receptor. (468 aa)
G3QF49_GORGOAzurocidin 1. (251 aa)
SELPSelectin P. (830 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
LCE3BLate cornified envelope 3B. (95 aa)
CD4CD4 molecule. (458 aa)
SSC5DUncharacterized protein. (941 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (574 aa)
DEFA1BDEFENSIN domain-containing protein. (94 aa)
IL17FInterleukin 17F. (163 aa)
G3QRK3_GORGOBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
IL23RInterleukin 23 receptor. (629 aa)
G3QUU9_GORGOProtein S100; Belongs to the S-100 family. (101 aa)
G3QV30_GORGOGasdermin D. (532 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
G3QX42_GORGOBactericidal permeability increasing protein. (487 aa)
G3QX51_GORGOLipopolysaccharide binding protein. (481 aa)
TREM1IG domain-containing protein. (249 aa)
TAC1Tachykinin precursor 1. (129 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
ENSGGOP00000046335Uncharacterized protein. (118 aa)
ENSGGOP00000046073Protein S100; Belongs to the S-100 family. (101 aa)
ENSGGOP00000043190Uncharacterized protein. (234 aa)
TNFRSF14Uncharacterized protein. (193 aa)
ENSGGOP00000041400MACPF domain-containing protein. (686 aa)
ENSGGOP00000041365Drosha ribonuclease III. (1380 aa)
RPL30Ribosomal_L7Ae domain-containing protein. (115 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (111 aa)
RNASE7Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
ENSGGOP00000037086Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (72 aa)
OPTNOptineurin. (577 aa)
ENSGGOP00000031506DEFENSIN domain-containing protein. (93 aa)
G3SK93_GORGOHistone H2B; Belongs to the histone H2B family. (126 aa)
G3SK86_GORGOS100 calcium binding protein A7 like 2. (106 aa)
CHGAChromogranin A. (458 aa)
G3SJS6_GORGOBPI fold containing family C. (466 aa)
G3SIL0_GORGOAdhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1570 aa)
RNASE6Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. (150 aa)
UMODUromodulin. (690 aa)
G3SDI2_GORGOMajor histocompatibility complex, class I-related; Belongs to the MHC class I family. (341 aa)
G3SBB4_GORGORibosomal_L7Ae domain-containing protein. (133 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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