STRINGSTRING
GNAI2 GNAI2 PIK3CB PIK3CB CCS CCS ESR1 ESR1 ABL1 ABL1 NOD2 NOD2 G3R664_GORGO G3R664_GORGO G3RR23_GORGO G3RR23_GORGO G3R8T5_GORGO G3R8T5_GORGO SIRT3 SIRT3 EDN1 EDN1 C1H1orf226 C1H1orf226 NPR3 NPR3 PTK2B PTK2B VDR VDR S100A1 S100A1 ENSGGOP00000029911 ENSGGOP00000029911 ENSGGOP00000031235 ENSGGOP00000031235 ENSGGOP00000031272 ENSGGOP00000031272 EDN2 EDN2 ENSGGOP00000031987 ENSGGOP00000031987 ENSGGOP00000036653 ENSGGOP00000036653 ENSGGOP00000038997 ENSGGOP00000038997 ENSGGOP00000040681 ENSGGOP00000040681 DHFR DHFR ENSGGOP00000044877 ENSGGOP00000044877 ENSGGOP00000045523 ENSGGOP00000045523 ENSGGOP00000045621 ENSGGOP00000045621 SCARB1 SCARB1 FXN FXN ENSGGOP00000046735 ENSGGOP00000046735 RFK RFK GDNF GDNF AGTR2 AGTR2 SDHAF4 SDHAF4 HTR2B HTR2B PDP2 PDP2 ATP7A ATP7A NOD1 NOD1 G3S3Q5_GORGO G3S3Q5_GORGO FDX1 FDX1 G3S864_GORGO G3S864_GORGO PDP1 PDP1 RGN RGN GNAI3 GNAI3 G3SEV0_GORGO G3SEV0_GORGO NUS1 NUS1 SNCA SNCA HIF1A HIF1A ENSGGOP00000029762 ENSGGOP00000029762 FCER2 FCER2 IL1B IL1B IFNG IFNG G3QT76_GORGO G3QT76_GORGO POR POR G3QR10_GORGO G3QR10_GORGO RIPK3 RIPK3 TERF2 TERF2 FGF23 FGF23 ABL2 ABL2 TERT TERT CALM1 CALM1 FTMT FTMT NDUFA4 NDUFA4 G3QGD7_GORGO G3QGD7_GORGO CALM3 CALM3 CDH3 CDH3 G3RNV7_GORGO G3RNV7_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI2G protein subunit alpha i2. (355 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
G3R664_GORGOUncharacterized protein. (226 aa)
G3RR23_GORGOUncharacterized protein. (210 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
EDN1Endothelin 1. (212 aa)
C1H1orf226Nitric oxide synthase 1 adaptor protein. (506 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
VDRVitamin D receptor. (477 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
ENSGGOP00000029911Uncharacterized protein. (77 aa)
ENSGGOP00000031235Uncharacterized protein; Belongs to the calmodulin family. (129 aa)
ENSGGOP00000031272Cytochrome c oxidase assembly factor 8. (206 aa)
EDN2Endothelin 2. (178 aa)
ENSGGOP00000031987Uncharacterized protein. (69 aa)
ENSGGOP00000036653Endothelin 3. (224 aa)
ENSGGOP00000038997Uncharacterized protein. (178 aa)
ENSGGOP00000040681Uncharacterized protein; Belongs to the calmodulin family. (70 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
ENSGGOP00000044877Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
ENSGGOP00000045523Uncharacterized protein. (281 aa)
ENSGGOP00000045621Uncharacterized protein. (252 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
FXNFrataxin. (210 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
RFKRiboflavin kinase. (127 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SDHAF4Succinate dehydrogenase complex assembly factor 4. (108 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (529 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
G3S3Q5_GORGOUncharacterized protein. (706 aa)
FDX12Fe-2S ferredoxin-type domain-containing protein. (158 aa)
G3S864_GORGOFlavokinase domain-containing protein. (136 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (596 aa)
RGNRegucalcin. (299 aa)
GNAI3G protein subunit alpha i3. (354 aa)
G3SEV0_GORGOUncharacterized protein; Belongs to the calmodulin family. (152 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
FCER2Fc fragment of IgE receptor II. (321 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
G3QR10_GORGOUncharacterized protein. (98 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (242 aa)
NDUFA4Cytochrome c oxidase subunit NDUFA4; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport [...] (81 aa)
G3QGD7_GORGOCytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
G3RNV7_GORGO2Fe-2S ferredoxin-type domain-containing protein. (165 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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