STRINGSTRING
CAV3 CAV3 HAMP HAMP PTEN PTEN TGFBR3 TGFBR3 CXADR CXADR HEY2 HEY2 RGS2 RGS2 BMPR1A BMPR1A TOMM70 TOMM70 GSK3A GSK3A G3QQC9_GORGO G3QQC9_GORGO IGF1 IGF1 FGF9 FGF9 YAP1 YAP1 G3QZ51_GORGO G3QZ51_GORGO TBX2 TBX2 WNT2 WNT2 FGF20 FGF20 NOTCH1 NOTCH1 G3R4E1_GORGO G3R4E1_GORGO CTDP1 CTDP1 RGS4 RGS4 EDN1 EDN1 CDK1 CDK1 TBX5 TBX5 SAV1 SAV1 G3RFV2_GORGO G3RFV2_GORGO PROX1 PROX1 DUSP9 DUSP9 G3RHQ4_GORGO G3RHQ4_GORGO CITED2 CITED2 TGFBR2 TGFBR2 NKX2-5 NKX2-5 G3RNB7_GORGO G3RNB7_GORGO AKAP6 AKAP6 G3RQI9_GORGO G3RQI9_GORGO PARP2 PARP2 TBX20 TBX20 GATA6 GATA6 PI16 PI16 PIM1 PIM1 MAPK11 MAPK11 YY1 YY1 KCNK2 KCNK2 DUSP6 DUSP6 JARID2 JARID2 BASP1 BASP1 ENSGGOP00000031261 ENSGGOP00000031261 WT1 WT1 BMP10 BMP10 RUNX1 RUNX1 GLI1 GLI1 PPARA PPARA NRG1 NRG1 ERBB4 ERBB4 RBPJ RBPJ ACACB ACACB VGLL4 VGLL4 ZFPM2 ZFPM2 ENSGGOP00000049072 ENSGGOP00000049072 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
CXADRCXADR Ig-like cell adhesion molecule. (352 aa)
HEY2Orange domain-containing protein. (257 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
G3QQC9_GORGOGlucose-6-phosphate dehydrogenase. (561 aa)
IGF1IlGF domain-containing protein. (196 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
YAP1Uncharacterized protein. (326 aa)
G3QZ51_GORGOFibroblast growth factor receptor. (822 aa)
TBX2T-box transcription factor 2. (580 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
NOTCH1Uncharacterized protein. (1606 aa)
G3R4E1_GORGOForkhead box P1. (693 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
RGS4Regulator of G protein signaling 4. (302 aa)
EDN1Endothelin 1. (212 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
TBX5T-box transcription factor 5. (518 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
G3RFV2_GORGOMyosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PROX1Prospero homeobox 1. (737 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
G3RHQ4_GORGOTumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NKX2-5NK2 homeobox 5. (324 aa)
G3RNB7_GORGOUncharacterized protein. (661 aa)
AKAP6A-kinase anchoring protein 6. (2318 aa)
G3RQI9_GORGOWW domain-containing protein. (413 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
TBX20T-box transcription factor 20. (447 aa)
GATA6GATA binding protein 6. (596 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (463 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
YY1YY1 transcription factor. (414 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
BASP1Brain abundant membrane attached signal protein 1. (233 aa)
ENSGGOP00000031261Myocyte enhancer factor 2C. (483 aa)
WT1Uncharacterized protein. (516 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
GLI1GLI family zinc finger 1. (1106 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
NRG1Neuregulin 1. (713 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
VGLL4Vestigial like family member 4. (296 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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