STRINGSTRING
MUTYH MUTYH CASP2 CASP2 ADPRHL2 ADPRHL2 BIRC3 BIRC3 ARHGEF2 ARHGEF2 BIRC2 BIRC2 RBCK1 RBCK1 RIPK1 RIPK1 PELI1 PELI1 RNF31 RNF31 FADD FADD CAV1 CAV1 YBX3 YBX3 ENSGGOP00000032772 ENSGGOP00000032772 ENSGGOP00000033404 ENSGGOP00000033404 SLC25A4 SLC25A4 BOK BOK FZD9 FZD9 ENSGGOP00000050852 ENSGGOP00000050852
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (556 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
RBCK1Uncharacterized protein. (204 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
RNF31Uncharacterized protein. (1072 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
YBX3Y-box binding protein 3. (373 aa)
ENSGGOP00000032772Uncharacterized protein. (104 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ENSGGOP00000050852annotation not available (362 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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