(54 nodes) Ureteric bud morphogenesis network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX9	SRY-box transcription factor 9. (509 aa)
	ENSGGOP00000050768	Paired box 2. (392 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
	PTCH1	Patched 1. (1447 aa)
	ENSGGOP00000045423	Homeobox domain-containing protein. (228 aa)
	ENSGGOP00000044374	Nephronectin. (609 aa)
	ILK	Integrin linked kinase. (535 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (258 aa)
	WT1	Uncharacterized protein. (516 aa)
	PAX8	Paired domain-containing protein. (457 aa)
	HOXA11	Homeobox A11. (315 aa)
	G3SF27_GORGO	Sulfotransferase; Belongs to the sulfotransferase 1 family. (372 aa)
	ENSGGOP00000024523	annotation not available (408 aa)
	G3S6C5_GORGO	CTCK domain-containing protein. (143 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
	GZF1	GDNF inducible zinc finger protein 1. (712 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1924 aa)
	TMEM59L	Transmembrane protein 59 like. (342 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
	PGF	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (323 aa)
	PBX1	PBX homeobox 1. (430 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	G3QZL1_GORGO	Laminin subunit alpha 5. (3447 aa)
	GATA3	GATA binding protein 3. (444 aa)
	TCF21	Transcription factor 21. (179 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	LHX1	LIM homeobox 1. (406 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	SIX1	Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] (284 aa)
	FMN1	Formin 1. (1425 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	SALL1	Spalt like transcription factor 1. (1324 aa)
	DCHS1	Dachsous cadherin-related 1. (3298 aa)
	G3QD11_GORGO	Growth regulating estrogen receptor binding 1. (1732 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTNNB1	ENSGGOP00000000778	ENSGGOP00000048898	BCL2 apoptosis regulator.	Catenin beta 1.	0.597
BCL2	FGF2	ENSGGOP00000000778	ENSGGOP00000033172	BCL2 apoptosis regulator.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.467
BCL2	SMAD4	ENSGGOP00000000778	ENSGGOP00000013332	BCL2 apoptosis regulator.	Mothers against decapentaplegic homolog.	0.500
BMP2	BMP4	ENSGGOP00000021281	ENSGGOP00000014564	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.949
BMP2	CTNNB1	ENSGGOP00000021281	ENSGGOP00000048898	Bone morphogenetic protein 2.	Catenin beta 1.	0.593
BMP2	ENSGGOP00000024523	ENSGGOP00000021281	ENSGGOP00000024523	Bone morphogenetic protein 2.	annotation not available	0.515
BMP2	FGF1	ENSGGOP00000021281	ENSGGOP00000017663	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.477
BMP2	FGF2	ENSGGOP00000021281	ENSGGOP00000033172	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.680
BMP2	FGF8	ENSGGOP00000021281	ENSGGOP00000014743	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.651
BMP2	G3S6C5_GORGO	ENSGGOP00000021281	ENSGGOP00000023632	Bone morphogenetic protein 2.	CTCK domain-containing protein.	0.824
BMP2	SHH	ENSGGOP00000021281	ENSGGOP00000013669	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.611
BMP2	SMAD4	ENSGGOP00000021281	ENSGGOP00000013332	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.866
BMP2	SOX9	ENSGGOP00000021281	ENSGGOP00000016791	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.612
BMP2	WNT4	ENSGGOP00000021281	ENSGGOP00000047347	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.412
BMP4	BMP2	ENSGGOP00000014564	ENSGGOP00000021281	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.949
BMP4	CTNNB1	ENSGGOP00000014564	ENSGGOP00000048898	Bone morphogenetic protein 4.	Catenin beta 1.	0.516
BMP4	FGF2	ENSGGOP00000014564	ENSGGOP00000033172	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	FGF8	ENSGGOP00000014564	ENSGGOP00000014743	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP4	G3S6C5_GORGO	ENSGGOP00000014564	ENSGGOP00000023632	Bone morphogenetic protein 4.	CTCK domain-containing protein.	0.623
BMP4	PTCH1	ENSGGOP00000014564	ENSGGOP00000046413	Bone morphogenetic protein 4.	Patched 1.	0.430