STRINGSTRING
SEMA7A SEMA7A MAPKAPK2 MAPKAPK2 PLCG2 PLCG2 TLR3 TLR3 NOD1 NOD1 TLR7 TLR7 RTN4 RTN4 PYCARD PYCARD LAPTM5 LAPTM5 G3R7S6_GORGO G3R7S6_GORGO RIPK2 RIPK2 NOD2 NOD2 SIRT1 SIRT1 WNT5A WNT5A G3QW36_GORGO G3QW36_GORGO G3QUW7_GORGO G3QUW7_GORGO GPRC5B GPRC5B CD36 CD36 PANX-2 PANX-2 G3QRP1_GORGO G3QRP1_GORGO MYD88 MYD88 SPON2 SPON2 ENSGGOP00000048129 ENSGGOP00000048129
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RTN4Reticulon. (1192 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
G3R7S6_GORGOCD74 molecule. (296 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
SIRT1Sirtuin 1. (751 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
G3QW36_GORGOUncharacterized protein. (652 aa)
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PANX-2Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
G3QRP1_GORGOUncharacterized protein. (107 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
SPON2Spondin 2. (331 aa)
ENSGGOP00000048129Caspase recruitment domain family member 9. (536 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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