node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD36 | MYD88 | ENSGGOP00000005986 | ENSGGOP00000003761 | CD36 molecule; Belongs to the CD36 family. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.494 |
CD36 | SIRT1 | ENSGGOP00000005986 | ENSGGOP00000009943 | CD36 molecule; Belongs to the CD36 family. | Sirtuin 1. | 0.495 |
ENSGGOP00000048129 | MYD88 | ENSGGOP00000048129 | ENSGGOP00000003761 | Caspase recruitment domain family member 9. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.663 |
ENSGGOP00000048129 | NOD1 | ENSGGOP00000048129 | ENSGGOP00000022426 | Caspase recruitment domain family member 9. | Nucleotide binding oligomerization domain containing 1. | 0.556 |
ENSGGOP00000048129 | NOD2 | ENSGGOP00000048129 | ENSGGOP00000010525 | Caspase recruitment domain family member 9. | Nucleotide binding oligomerization domain containing 2. | 0.866 |
ENSGGOP00000048129 | PYCARD | ENSGGOP00000048129 | ENSGGOP00000016734 | Caspase recruitment domain family member 9. | PYD and CARD domain containing. | 0.555 |
ENSGGOP00000048129 | RIPK2 | ENSGGOP00000048129 | ENSGGOP00000010569 | Caspase recruitment domain family member 9. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.660 |
G3QRP1_GORGO | PANX-2 | ENSGGOP00000005301 | ENSGGOP00000005479 | Uncharacterized protein. | Pannexin; Structural component of the gap junctions and the hemichannels. | 0.708 |
G3QUW7_GORGO | MYD88 | ENSGGOP00000006528 | ENSGGOP00000003761 | TIR domain-containing adapter molecule 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.702 |
G3QUW7_GORGO | TLR3 | ENSGGOP00000006528 | ENSGGOP00000027247 | TIR domain-containing adapter molecule 1. | Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. | 0.987 |
G3QUW7_GORGO | TLR7 | ENSGGOP00000006528 | ENSGGOP00000020624 | TIR domain-containing adapter molecule 1. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.671 |
MYD88 | CD36 | ENSGGOP00000003761 | ENSGGOP00000005986 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | CD36 molecule; Belongs to the CD36 family. | 0.494 |
MYD88 | ENSGGOP00000048129 | ENSGGOP00000003761 | ENSGGOP00000048129 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Caspase recruitment domain family member 9. | 0.663 |
MYD88 | G3QUW7_GORGO | ENSGGOP00000003761 | ENSGGOP00000006528 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | TIR domain-containing adapter molecule 1. | 0.702 |
MYD88 | NOD1 | ENSGGOP00000003761 | ENSGGOP00000022426 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Nucleotide binding oligomerization domain containing 1. | 0.571 |
MYD88 | NOD2 | ENSGGOP00000003761 | ENSGGOP00000010525 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Nucleotide binding oligomerization domain containing 2. | 0.694 |
MYD88 | PYCARD | ENSGGOP00000003761 | ENSGGOP00000016734 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | PYD and CARD domain containing. | 0.670 |
MYD88 | RIPK2 | ENSGGOP00000003761 | ENSGGOP00000010569 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.623 |
MYD88 | SIRT1 | ENSGGOP00000003761 | ENSGGOP00000009943 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Sirtuin 1. | 0.478 |
MYD88 | TLR3 | ENSGGOP00000003761 | ENSGGOP00000027247 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. | 0.985 |