(46 nodes) Regulation of miRNA-mediated gene silencing network (Gorilla gorilla)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGGOP00000043083	Nuclear receptor corepressor 2. (2519 aa)
	LIN28A	Lin-28 homolog A. (209 aa)
	ENSGGOP00000045124	HNF1 homeobox A. (662 aa)
	G3QJF9_GORGO	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
	LIMD1	LIM domains containing 1. (676 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	TRUB1	TruB pseudouridine synthase family member 1. (349 aa)
	MYCN	MYCN proto-oncogene, bHLH transcription factor. (464 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	G3R0F2_GORGO	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	FMR1	Fragile X mental retardation 1. (624 aa)
	PUM1	Pumilio RNA binding family member 1. (1216 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (526 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	G3RBI6_GORGO	RRM domain-containing protein. (353 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1603 aa)
	ZFP36	ZFP36 ring finger protein. (332 aa)
	AJUBA	Ajuba LIM protein. (538 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	DND1	RRM domain-containing protein. (353 aa)
	IL6	Interleukin 6. (234 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	WTIP	Uncharacterized protein. (279 aa)
	ELAVL1	ELAV-like protein; Belongs to the RRM elav family. (326 aa)
	ENSGGOP00000024523	annotation not available (408 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	DHX9	DExH-box helicase 9. (1270 aa)
	ZC3H10	Zinc finger CCCH-type containing 10. (434 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	ENSGGOP00000035103	Protein kinase domain-containing protein. (379 aa)
	FXR1	Uncharacterized protein. (778 aa)
	ENSGGOP00000038080	Uncharacterized protein. (54 aa)
	ENSGGOP00000038747	Uncharacterized protein. (1063 aa)
	ENSGGOP00000038823	Nuclear receptor corepressor 1. (2386 aa)
	LIN28B	Lin-28 homolog B. (258 aa)
	ENSGGOP00000040146	CCHC-type domain-containing protein. (203 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)
	ENSGGOP00000046487	TIA1 cytotoxic granule associated RNA binding protein like 1. (405 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	PUM2	Pumilio RNA binding family member 2. (1065 aa)
	ENSGGOP00000049691	RRM domain-containing protein. (330 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJUBA	ENSGGOP00000038823	ENSGGOP00000014181	ENSGGOP00000038823	Ajuba LIM protein.	Nuclear receptor corepressor 1.	0.854
AJUBA	LIMD1	ENSGGOP00000014181	ENSGGOP00000002719	Ajuba LIM protein.	LIM domains containing 1.	0.947
AJUBA	WTIP	ENSGGOP00000014181	ENSGGOP00000022405	Ajuba LIM protein.	Uncharacterized protein.	0.946
BMP4	IL6	ENSGGOP00000014564	ENSGGOP00000018546	Bone morphogenetic protein 4.	Interleukin 6.	0.458
DDX5	DHX9	ENSGGOP00000047340	ENSGGOP00000026976	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DExH-box helicase 9.	0.947
DDX5	EIF4G1	ENSGGOP00000047340	ENSGGOP00000013587	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 1.	0.427
DDX5	ELAVL1	ENSGGOP00000047340	ENSGGOP00000023864	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	ELAV-like protein; Belongs to the RRM elav family.	0.475
DDX5	ENSGGOP00000038080	ENSGGOP00000047340	ENSGGOP00000038080	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.726
DDX5	ENSGGOP00000038747	ENSGGOP00000047340	ENSGGOP00000038747	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.922
DDX5	ESR1	ENSGGOP00000047340	ENSGGOP00000009454	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.935
DDX5	FMR1	ENSGGOP00000047340	ENSGGOP00000010124	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Fragile X mental retardation 1.	0.505
DDX5	FXR1	ENSGGOP00000047340	ENSGGOP00000035407	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.556
DDX5	LIN28B	ENSGGOP00000047340	ENSGGOP00000040021	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Lin-28 homolog B.	0.438
DDX5	TRUB1	ENSGGOP00000047340	ENSGGOP00000004496	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	TruB pseudouridine synthase family member 1.	0.497
DHX9	DDX5	ENSGGOP00000026976	ENSGGOP00000047340	DExH-box helicase 9.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.947
DHX9	EGFR	ENSGGOP00000026976	ENSGGOP00000041101	DExH-box helicase 9.	Receptor protein-tyrosine kinase.	0.496
DHX9	ELAVL1	ENSGGOP00000026976	ENSGGOP00000023864	DExH-box helicase 9.	ELAV-like protein; Belongs to the RRM elav family.	0.696
DHX9	LIN28A	ENSGGOP00000026976	ENSGGOP00000044505	DExH-box helicase 9.	Lin-28 homolog A.	0.537
DHX9	ZFP36	ENSGGOP00000026976	ENSGGOP00000014039	DExH-box helicase 9.	ZFP36 ring finger protein.	0.437
EGFR	DHX9	ENSGGOP00000041101	ENSGGOP00000026976	Receptor protein-tyrosine kinase.	DExH-box helicase 9.	0.496