(46 nodes) Coronary vasculature development network (Gorilla gorilla)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	GATA6	GATA binding protein 6. (596 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1248 aa)
	G3S176_GORGO	MADS-box domain-containing protein. (473 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	AP2B1	AP complex subunit beta. (951 aa)
	ENSGGOP00000024523	annotation not available (408 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	MYOCD	Myocardin. (986 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	MEGF8	Multiple EGF like domains 8. (2845 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	ENSGGOP00000036799	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	ENSGGOP00000037971	Uncharacterized protein. (170 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	APLN	Apelin. (77 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	PLXND1	Plexin D1. (1925 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (860 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	PRDM1	PR/SET domain 1. (825 aa)
	HEY2	Orange domain-containing protein. (257 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (198 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	SGCD	Sarcoglycan delta. (290 aa)
	TBX1	Uncharacterized protein. (311 aa)
	NOTCH1	Uncharacterized protein. (1606 aa)
	SNX17	Sorting nexin 17. (470 aa)
	MMP21	Matrix metallopeptidase 21. (568 aa)
	VEGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
	DCTN5	Dynactin subunit 5. (182 aa)
	G3RB41_GORGO	Mothers against decapentaplegic homolog. (435 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	ARID2	AT-rich interaction domain 2. (1834 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (266 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1. (3086 aa)
	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
	LRP2	LDL receptor related protein 2. (4653 aa)
	ZBTB14	Zinc finger and BTB domain containing 14. (449 aa)
	CNTRL	Centriolin. (2322 aa)
	ENSGGOP00000048177	B2-adapt-app_C domain-containing protein. (874 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2B1	LRP2	ENSGGOP00000022735	ENSGGOP00000016227	AP complex subunit beta.	LDL receptor related protein 2.	0.508
APELA	APLN	ENSGGOP00000038050	ENSGGOP00000041213	Apelin receptor early endogenous ligand.	Apelin.	0.597
APELA	APLNR	ENSGGOP00000038050	ENSGGOP00000024678	Apelin receptor early endogenous ligand.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.944
APLN	APELA	ENSGGOP00000041213	ENSGGOP00000038050	Apelin.	Apelin receptor early endogenous ligand.	0.597
APLN	APLNR	ENSGGOP00000041213	ENSGGOP00000024678	Apelin.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.998
APLNR	APELA	ENSGGOP00000024678	ENSGGOP00000038050	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor early endogenous ligand.	0.944
APLNR	APLN	ENSGGOP00000024678	ENSGGOP00000041213	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin.	0.998
ARID2	SETD2	ENSGGOP00000013569	ENSGGOP00000041243	AT-rich interaction domain 2.	SET domain containing 2, histone lysine methyltransferase.	0.448
BMP4	G3RB41_GORGO	ENSGGOP00000014564	ENSGGOP00000012678	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.626
BMP4	GATA6	ENSGGOP00000014564	ENSGGOP00000021097	Bone morphogenetic protein 4.	GATA binding protein 6.	0.508
BMP4	TGFBR1	ENSGGOP00000014564	ENSGGOP00000051200	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.722
BMP4	TGFBR3	ENSGGOP00000014564	ENSGGOP00000000910	Bone morphogenetic protein 4.	Transforming growth factor beta receptor 3.	0.508
DCTN5	DYNC2H1	ENSGGOP00000012515	ENSGGOP00000012238	Dynactin subunit 5.	Dynein cytoplasmic 2 heavy chain 1.	0.467
DCTN5	ENSGGOP00000037971	ENSGGOP00000012515	ENSGGOP00000037971	Dynactin subunit 5.	Uncharacterized protein.	0.544
DYNC2H1	DCTN5	ENSGGOP00000012238	ENSGGOP00000012515	Dynein cytoplasmic 2 heavy chain 1.	Dynactin subunit 5.	0.467
DYNC2H1	ENSGGOP00000037971	ENSGGOP00000012238	ENSGGOP00000037971	Dynein cytoplasmic 2 heavy chain 1.	Uncharacterized protein.	0.467
ENSGGOP00000024523	G3RB41_GORGO	ENSGGOP00000024523	ENSGGOP00000012678	annotation not available	Mothers against decapentaplegic homolog.	0.626
ENSGGOP00000024523	GATA6	ENSGGOP00000024523	ENSGGOP00000021097	annotation not available	GATA binding protein 6.	0.419
ENSGGOP00000024523	TGFBR1	ENSGGOP00000024523	ENSGGOP00000051200	annotation not available	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.722
ENSGGOP00000024523	TGFBR3	ENSGGOP00000024523	ENSGGOP00000000910	annotation not available	Transforming growth factor beta receptor 3.	0.508