(19 nodes) Dendritic spine morphogenesis network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (745 aa)
	EPHB2	EPH receptor B2. (1113 aa)
	WNT7A	Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (345 aa)
	EPHB1	EPH receptor B1. (984 aa)
	HDAC6	Histone deacetylase 6. (1218 aa)
	G3RNB7_GORGO	Uncharacterized protein. (661 aa)
	ZNF365	Uncharacterized protein. (346 aa)
	G3RWI8_GORGO	Catenin delta 2. (1148 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	G3SE25_GORGO	SH3 and multiple ankyrin repeat domains 3. (1605 aa)
	CDC42	Cell division cycle 42. (191 aa)
	ENSGGOP00000032699	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (502 aa)
	DIP2A	Disco interacting protein 2 homolog A. (1571 aa)
	EPHB3	EPH receptor B3. (997 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2180 aa)
	ENSGGOP00000047465	P21 (RAC1) activated kinase 3. (580 aa)
	ENSGGOP00000042381	Uncharacterized protein. (1742 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARC	DLG4	ENSGGOP00000004594	ENSGGOP00000006603	Activity regulated cytoskeleton associated protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.683
CDC42	DLG4	ENSGGOP00000043168	ENSGGOP00000006603	Cell division cycle 42.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.589
CDC42	DOCK10	ENSGGOP00000043168	ENSGGOP00000039427	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.946
CDC42	ENSGGOP00000042381	ENSGGOP00000043168	ENSGGOP00000042381	Cell division cycle 42.	Uncharacterized protein.	0.411
CDC42	ENSGGOP00000047465	ENSGGOP00000043168	ENSGGOP00000047465	Cell division cycle 42.	P21 (RAC1) activated kinase 3.	0.971
CDC42	EPHB2	ENSGGOP00000043168	ENSGGOP00000008163	Cell division cycle 42.	EPH receptor B2.	0.666
CDC42	G3RNB7_GORGO	ENSGGOP00000043168	ENSGGOP00000017283	Cell division cycle 42.	Uncharacterized protein.	0.490
CDC42	G3SE25_GORGO	ENSGGOP00000043168	ENSGGOP00000026355	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 3.	0.446
CDC42	HDAC6	ENSGGOP00000043168	ENSGGOP00000049791	Cell division cycle 42.	Histone deacetylase 6.	0.400
CDC42	PTEN	ENSGGOP00000043168	ENSGGOP00000000877	Cell division cycle 42.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.953
CDC42	WASL	ENSGGOP00000043168	ENSGGOP00000022782	Cell division cycle 42.	WASP like actin nucleation promoting factor.	0.999
DLG4	ARC	ENSGGOP00000006603	ENSGGOP00000004594	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Activity regulated cytoskeleton associated protein.	0.683
DLG4	CDC42	ENSGGOP00000006603	ENSGGOP00000043168	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Cell division cycle 42.	0.589
DLG4	ENSGGOP00000042381	ENSGGOP00000006603	ENSGGOP00000042381	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Uncharacterized protein.	0.911
DLG4	G3RNB7_GORGO	ENSGGOP00000006603	ENSGGOP00000017283	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Uncharacterized protein.	0.524
DLG4	G3SE25_GORGO	ENSGGOP00000006603	ENSGGOP00000026355	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 3.	0.920
DLG4	PTEN	ENSGGOP00000006603	ENSGGOP00000000877	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.584
DOCK10	CDC42	ENSGGOP00000039427	ENSGGOP00000043168	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Cell division cycle 42.	0.946
ENSGGOP00000042381	CDC42	ENSGGOP00000042381	ENSGGOP00000043168	Uncharacterized protein.	Cell division cycle 42.	0.411
ENSGGOP00000042381	DLG4	ENSGGOP00000042381	ENSGGOP00000006603	Uncharacterized protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.911