79 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	SGO2	Shugoshin 2. (1266 aa)
	ENSGGOP00000039935	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
	SYCP2	Synaptonemal complex protein 2. (1530 aa)
	RAD51C	Uncharacterized protein. (52 aa)
	BAG6	BCL2 associated athanogene 6. (1190 aa)
	ATRX	ATRX chromatin remodeler. (2492 aa)
	ENSGGOP00000041237	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (377 aa)
	SUN1	MRP domain-containing protein. (168 aa)
	CCDC36	Coiled-coil domain containing 36. (595 aa)
	ENSGGOP00000044817	MutL homolog 3. (1410 aa)
	ENSGGOP00000046210	annotation not available (52 aa)
	NCAPH	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
	SMC2	Structural maintenance of chromosomes protein. (1197 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (385 aa)
	TEX11	Testis expressed 11. (940 aa)
	HORMAD1	HORMA domain containing 1. (394 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1094 aa)
	HORMAD2	HORMA domain containing 2. (307 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1267 aa)
	MEIKIN	Meiotic kinetochore factor. (373 aa)
	G3QIE9_GORGO	Uncharacterized protein. (202 aa)
	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B. (1068 aa)
	SYCE3	Synaptonemal complex central element protein 3. (88 aa)
	TERB1	Telomere repeat binding bouquet formation protein 1. (727 aa)
	SYCE1	Synaptonemal complex central element protein 1. (351 aa)
	STAG2	Stromal antigen 2. (1268 aa)
	ZCWPW1	Zinc finger CW-type and PWWP domain containing 1. (648 aa)
	SGO1	Shugoshin 1. (527 aa)
	C1H1orf146	Chromosome 1 open reading frame 146. (180 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	NCAPD3	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1498 aa)
	G3QZ33_GORGO	Uncharacterized protein; Belongs to the AAA ATPase family. (362 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
	NCAPD2	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1401 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (437 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
	C14H14orf39	Chromosome 14 open reading frame 39. (587 aa)
	PSMC3IP	PSMC3 interacting protein. (217 aa)
	G3R5X1_GORGO	Non-SMC condensin II complex subunit H2. (546 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
	G3R6T7_GORGO	DNA_MISMATCH_REPAIR_2 domain-containing protein. (839 aa)
	RAD21	RAD21 cohesin complex component. (631 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (952 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (526 aa)
	G3RA70_GORGO	SUN domain-containing protein. (653 aa)
	SYCE1L	Uncharacterized protein. (212 aa)
	SMC4	Structural maintenance of chromosomes protein. (1288 aa)
	SIRT7	Sirtuin 7. (400 aa)
	G3RED9_GORGO	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
	NDC1	NDC1 transmembrane nucleoporin. (674 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	G3RHR8_GORGO	Synaptonemal complex protein 1. (942 aa)
	REC8	REC8 meiotic recombination protein. (547 aa)
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	MLH1	MutL homolog 1. (756 aa)
	ANKRD31	Ankyrin repeat domain 31. (1880 aa)
	G3RP17_GORGO	Structural maintenance of chromosomes protein. (1175 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (838 aa)
	RNF212	Ring finger protein 212. (297 aa)
	G3RYI7_GORGO	Telomere repeat binding bouquet formation protein 2. (192 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	PRDM9	PR/SET domain 9. (822 aa)
	SYCE2	Uncharacterized protein. (126 aa)
	G3SB61_GORGO	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (370 aa)
	STAG3	Stromal antigen 3. (1221 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3179 aa)
	MAJIN	Uncharacterized protein. (176 aa)
	SPATA22	Spermatogenesis associated 22. (363 aa)
	ENSGGOP00000032803	MutS homolog 4. (844 aa)
	ENSGGOP00000034312	FA complementation group D2. (1390 aa)
	ENSGGOP00000035259	Structural maintenance of chromosomes 1A. (1096 aa)
	ENSGGOP00000036812	HORMA domain-containing protein. (363 aa)
	STAG1	Stromal antigen 1. (1258 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD31	CCDC36	ENSGGOP00000016643	ENSGGOP00000043640	Ankyrin repeat domain 31.	Coiled-coil domain containing 36.	0.672
ANKRD31	G3RHR8_GORGO	ENSGGOP00000016643	ENSGGOP00000015196	Ankyrin repeat domain 31.	Synaptonemal complex protein 1.	0.404
ANKRD31	MEI4	ENSGGOP00000016643	ENSGGOP00000046511	Ankyrin repeat domain 31.	Meiotic double-stranded break formation protein 4.	0.564
ANKRD31	PRDM9	ENSGGOP00000016643	ENSGGOP00000022130	Ankyrin repeat domain 31.	PR/SET domain 9.	0.470
ATM	ATRX	ENSGGOP00000010144	ENSGGOP00000040984	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATRX chromatin remodeler.	0.740
ATM	BRIP1	ENSGGOP00000010144	ENSGGOP00000008668	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 interacting protein C-terminal helicase 1.	0.910
ATM	DMC1	ENSGGOP00000010144	ENSGGOP00000010934	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.905
ATM	ENSGGOP00000032803	ENSGGOP00000010144	ENSGGOP00000032803	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutS homolog 4.	0.645
ATM	ENSGGOP00000034312	ENSGGOP00000010144	ENSGGOP00000034312	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group D2.	0.864
ATM	ENSGGOP00000035259	ENSGGOP00000010144	ENSGGOP00000035259	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Structural maintenance of chromosomes 1A.	0.682
ATM	ENSGGOP00000044817	ENSGGOP00000010144	ENSGGOP00000044817	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 3.	0.753
ATM	ENSGGOP00000046210	ENSGGOP00000010144	ENSGGOP00000046210	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.759
ATM	G3R6T7_GORGO	ENSGGOP00000010144	ENSGGOP00000011057	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.602
ATM	G3RED9_GORGO	ENSGGOP00000010144	ENSGGOP00000013922	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.969
ATM	G3RP17_GORGO	ENSGGOP00000010144	ENSGGOP00000017536	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Structural maintenance of chromosomes protein.	0.549
ATM	G3SB61_GORGO	ENSGGOP00000010144	ENSGGOP00000025335	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.725
ATM	MEIOB	ENSGGOP00000010144	ENSGGOP00000011969	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiosis specific with OB-fold.	0.762
ATM	MLH1	ENSGGOP00000010144	ENSGGOP00000015949	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1.	0.935
ATM	MRE11	ENSGGOP00000010144	ENSGGOP00000021103	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.995
ATM	RAD51C	ENSGGOP00000010144	ENSGGOP00000040198	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.821