(30 nodes) Pyroptosis network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CARD8	Caspase recruitment domain family member 8. (522 aa)
	DPP9	Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (892 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	GZMA	Granzyme A; Belongs to the peptidase S1 family. (262 aa)
	MEFV	MEFV innate immuity regulator, pyrin. (781 aa)
	G3RI71_GORGO	NACHT domain-containing protein. (1127 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	G3RB29_GORGO	Granzyme B; Belongs to the peptidase S1 family. (247 aa)
	NLRP1	NLR family pyrin domain containing 1. (1471 aa)
	ZBP1	Z-DNA binding protein 1. (429 aa)
	G3QV30_GORGO	Gasdermin D. (532 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	GSDME	Gasdermin E. (496 aa)
	GSDMA	Gasdermin A. (445 aa)
	GSDMC	Gasdermin C. (507 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	G3QER9_GORGO	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
	APIP	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa)
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	NLRP6	Uncharacterized protein. (912 aa)
	ENSGGOP00000045267	Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
	NAIP	Uncharacterized protein. (198 aa)
	ENSGGOP00000038747	Uncharacterized protein. (1063 aa)
	GSDMB	Gasdermin B. (416 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	ENSGGOP00000032091	Caspase 4; Belongs to the peptidase C14A family. (377 aa)
	ENSGGOP00000029367	Pyrin domain-containing protein. (110 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	DHX9	DExH-box helicase 9. (1270 aa)
	G3SE49_GORGO	NLR family pyrin domain containing 9. (934 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CARD8	ENSGGOP00000006002	ENSGGOP00000000255	Absent in melanoma 2.	Caspase recruitment domain family member 8.	0.826
AIM2	ENSGGOP00000029367	ENSGGOP00000006002	ENSGGOP00000029367	Absent in melanoma 2.	Pyrin domain-containing protein.	0.540
AIM2	ENSGGOP00000032091	ENSGGOP00000006002	ENSGGOP00000032091	Absent in melanoma 2.	Caspase 4; Belongs to the peptidase C14A family.	0.807
AIM2	ENSGGOP00000033404	ENSGGOP00000006002	ENSGGOP00000033404	Absent in melanoma 2.	Caspase 8; Belongs to the peptidase C14A family.	0.472
AIM2	ENSGGOP00000045267	ENSGGOP00000006002	ENSGGOP00000045267	Absent in melanoma 2.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.735
AIM2	ENSGGOP00000046758	ENSGGOP00000006002	ENSGGOP00000046758	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.991
AIM2	G3QV30_GORGO	ENSGGOP00000006002	ENSGGOP00000006593	Absent in melanoma 2.	Gasdermin D.	0.816
AIM2	G3RI71_GORGO	ENSGGOP00000006002	ENSGGOP00000015360	Absent in melanoma 2.	NACHT domain-containing protein.	0.672
AIM2	G3SE49_GORGO	ENSGGOP00000006002	ENSGGOP00000026379	Absent in melanoma 2.	NLR family pyrin domain containing 9.	0.594
AIM2	GSDMA	ENSGGOP00000006002	ENSGGOP00000004939	Absent in melanoma 2.	Gasdermin A.	0.497
AIM2	MEFV	ENSGGOP00000006002	ENSGGOP00000015416	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.977
AIM2	NAIP	ENSGGOP00000006002	ENSGGOP00000042462	Absent in melanoma 2.	Uncharacterized protein.	0.749
AIM2	NLRC4	ENSGGOP00000006002	ENSGGOP00000002707	Absent in melanoma 2.	NLR family CARD domain containing 4.	0.959
AIM2	NLRP1	ENSGGOP00000006002	ENSGGOP00000011186	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.977
AIM2	NLRP6	ENSGGOP00000006002	ENSGGOP00000045325	Absent in melanoma 2.	Uncharacterized protein.	0.949
AIM2	PYCARD	ENSGGOP00000006002	ENSGGOP00000016734	Absent in melanoma 2.	PYD and CARD domain containing.	0.999
AIM2	ZBP1	ENSGGOP00000006002	ENSGGOP00000010722	Absent in melanoma 2.	Z-DNA binding protein 1.	0.492
CARD8	AIM2	ENSGGOP00000000255	ENSGGOP00000006002	Caspase recruitment domain family member 8.	Absent in melanoma 2.	0.826
CARD8	DPP9	ENSGGOP00000000255	ENSGGOP00000016901	Caspase recruitment domain family member 8.	Dipeptidyl peptidase 9; Belongs to the peptidase S9B family.	0.929
CARD8	ENSGGOP00000029367	ENSGGOP00000000255	ENSGGOP00000029367	Caspase recruitment domain family member 8.	Pyrin domain-containing protein.	0.666