(84 nodes) Negative regulation of ERK1 and ERK2 cascade network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3RPB0_GORGO	Uncharacterized protein. (351 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	FLCN	Folliculin. (579 aa)
	DUSP10	Dual specificity phosphatase 10. (399 aa)
	G3QH75_GORGO	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (725 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
	G3QL78_GORGO	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (334 aa)
	PSCA	Prostate stem cell antigen. (123 aa)
	SPRED3	Uncharacterized protein. (453 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	DAB2	DAB adaptor protein 2. (770 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (270 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (462 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	G3QWN1_GORGO	Synaptojanin 2 binding protein. (145 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	EPHB2	EPH receptor B2. (1113 aa)
	NLRP12	NLR family pyrin domain containing 12. (1065 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
	G3R2F5_GORGO	Regulator of G protein signaling 14. (523 aa)
	G3R2M9_GORGO	Prohibitin. (194 aa)
	G3R3C7_GORGO	TBC1 domain family member 10C. (446 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	DUPD1	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	G3R883_GORGO	ANK_REP_REGION domain-containing protein. (1226 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	C1QL4	Complement C1q like 4. (238 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (211 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	PTPRR	Protein tyrosine phosphatase receptor type R. (657 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2175 aa)
	EPHA4	EPH receptor A4. (986 aa)
	G3RGU1_GORGO	ANK_REP_REGION domain-containing protein. (307 aa)
	DUSP9	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	GBP1	Guanylate binding protein 1. (592 aa)
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
	G3RKQ9_GORGO	CCDC144C domain-containing protein. (314 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (322 aa)
	G3RMA5_GORGO	Tyrosine-protein phosphatase non-receptor type. (415 aa)
	G3RNB7_GORGO	Uncharacterized protein. (661 aa)
	G3RPN5_GORGO	GB1/RHD3-type G domain-containing protein. (501 aa)
	G3RRK1_GORGO	Uncharacterized protein. (497 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (745 aa)
	G3RV54_GORGO	Protein tyrosine phosphatase receptor type C. (1306 aa)
	RANBP9	Uncharacterized protein. (388 aa)
	PHB	Prohibitin. (272 aa)
	SIRPA	Signal regulatory protein alpha. (508 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (288 aa)
	G3S132_GORGO	Prohibitin. (230 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (387 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1016 aa)
	G3SAN6_GORGO	Ankyrin repeat domain 30A. (1318 aa)
	VRK3	VRK serine/threonine kinase 3. (474 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	GSTP1	Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
	G3SHS9_GORGO	ANK_REP_REGION domain-containing protein. (499 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	ENSGGOP00000030134	Peptidyl-prolyl cis-trans isomerase. (155 aa)
	DAB2IP	DAB2 interacting protein. (1155 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	ENSGGOP00000035607	Uncharacterized protein. (125 aa)
	NDRG2	NDRG family member 2. (381 aa)
	DMD	Dystrophin. (3685 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (432 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	EZR	Ezrin. (604 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	ENSGGOP00000041843	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ENSGGOP00000043090	Prohibitin. (177 aa)
	TNIP1	TNFAIP3 interacting protein 1. (645 aa)
	ENSGGOP00000044168	Prohibitin. (258 aa)
	C3H3orf33	Chromosome 3 open reading frame 33. (251 aa)
	NLRP6	Uncharacterized protein. (912 aa)
	ENSGGOP00000047857	Uncharacterized protein. (1276 aa)
	ENSGGOP00000048090	LIM domain only 3. (167 aa)
	ENSGGOP00000051678	Butyrophilin subfamily 2 member A2. (523 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	DAB2	ENSGGOP00000010326	ENSGGOP00000005737	Tyrosine-protein kinase.	DAB adaptor protein 2.	0.427
ABL1	EPHA4	ENSGGOP00000010326	ENSGGOP00000014427	Tyrosine-protein kinase.	EPH receptor A4.	0.933
ABL1	EPHB2	ENSGGOP00000010326	ENSGGOP00000008163	Tyrosine-protein kinase.	EPH receptor B2.	0.935
ABL1	G3R2F5_GORGO	ENSGGOP00000010326	ENSGGOP00000009406	Tyrosine-protein kinase.	Regulator of G protein signaling 14.	0.517
ABL1	G3RMA5_GORGO	ENSGGOP00000010326	ENSGGOP00000016919	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.434
ABL1	G3RNB7_GORGO	ENSGGOP00000010326	ENSGGOP00000017283	Tyrosine-protein kinase.	Uncharacterized protein.	0.448
ABL1	G3RV54_GORGO	ENSGGOP00000010326	ENSGGOP00000019683	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.458
ABL1	LYN	ENSGGOP00000010326	ENSGGOP00000012189	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.401
ABL1	PTEN	ENSGGOP00000010326	ENSGGOP00000000877	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.517
ABL1	PTPN2	ENSGGOP00000010326	ENSGGOP00000024168	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.434
ABL1	SMAD4	ENSGGOP00000010326	ENSGGOP00000013332	Tyrosine-protein kinase.	Mothers against decapentaplegic homolog.	0.439
ACE2	G3QL78_GORGO	ENSGGOP00000007298	ENSGGOP00000003224	Angiotensin-converting enzyme.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.519
ATF3	SMAD4	ENSGGOP00000013856	ENSGGOP00000013332	Activating transcription factor 3.	Mothers against decapentaplegic homolog.	0.458
ATF3	XBP1	ENSGGOP00000013856	ENSGGOP00000038457	Activating transcription factor 3.	BZIP domain-containing protein.	0.660
CHRNA10	CHRNA9	ENSGGOP00000009251	ENSGGOP00000016127	Cholinergic receptor nicotinic alpha 10 subunit.	Cholinergic receptor nicotinic alpha 9 subunit.	0.909
CHRNA9	CHRNA10	ENSGGOP00000016127	ENSGGOP00000009251	Cholinergic receptor nicotinic alpha 9 subunit.	Cholinergic receptor nicotinic alpha 10 subunit.	0.909
CSK	G3QL78_GORGO	ENSGGOP00000010878	ENSGGOP00000003224	Tyrosine-protein kinase.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.530
CSK	G3RMA5_GORGO	ENSGGOP00000010878	ENSGGOP00000016919	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.626
CSK	G3RNB7_GORGO	ENSGGOP00000010878	ENSGGOP00000017283	Tyrosine-protein kinase.	Uncharacterized protein.	0.473
CSK	G3RRK1_GORGO	ENSGGOP00000010878	ENSGGOP00000018425	Tyrosine-protein kinase.	Uncharacterized protein.	0.406