STRINGSTRING
PLCB1 PLCB1 TRAF6 TRAF6 IL1B IL1B IKBKB IKBKB RPS6KA5 RPS6KA5 MYD88 MYD88 IL1RL2 IL1RL2 IL1R1 IL1R1 G3QHL6_GORGO G3QHL6_GORGO G3QFX1_GORGO G3QFX1_GORGO G3R9G9_GORGO G3R9G9_GORGO IRAK1 IRAK1 MAP3K7 MAP3K7 IRAK4 IRAK4 MAPK3 MAPK3 RELA RELA EGR1 EGR1 ENSGGOP00000031193 ENSGGOP00000031193 ENSGGOP00000031801 ENSGGOP00000031801 ENSGGOP00000035952 ENSGGOP00000035952 ENSGGOP00000039123 ENSGGOP00000039123 RPS6KA4 RPS6KA4 ENSGGOP00000041058 ENSGGOP00000041058
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL1RL2Interleukin 1 receptor like 2. (575 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
G3QHL6_GORGOInterleukin 1 receptor associated kinase 2. (538 aa)
G3QFX1_GORGOST18 C2H2C-type zinc finger transcription factor. (1047 aa)
G3R9G9_GORGOToll interacting protein. (223 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
ENSGGOP00000031193Uncharacterized protein. (93 aa)
ENSGGOP00000031801CCHC NOA-type domain-containing protein. (346 aa)
ENSGGOP00000035952TNF receptor-associated factor. (485 aa)
ENSGGOP00000039123CCHC NOA-type domain-containing protein. (371 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (511 aa)
ENSGGOP00000041058annotation not available (54 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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