STRINGSTRING
HBEGF HBEGF ARF4 ARF4 PSPN PSPN G3QDY6_GORGO G3QDY6_GORGO ITGA5 ITGA5 NPTN NPTN CSF2 CSF2 IL3 IL3 FGF21 FGF21 TRIP6 TRIP6 PDGFD PDGFD PSEN1 PSEN1 FAM83B FAM83B FGF16 FGF16 MS4A4A MS4A4A SNX2 SNX2 FRS3 FRS3 VEGFD VEGFD FGF5 FGF5 FGF23 FGF23 G3QL78_GORGO G3QL78_GORGO IL1R1 IL1R1 IL1A IL1A IL6ST IL6ST EREG EREG MYD88 MYD88 IL12B IL12B IL1RN IL1RN FGF10 FGF10 FGF9 FGF9 CSF3 CSF3 FGF7 FGF7 IL4 IL4 EGF EGF GRB2 GRB2 GATA3 GATA3 G3QTT4_GORGO G3QTT4_GORGO G3QU00_GORGO G3QU00_GORGO IL1B IL1B ERN1 ERN1 GLMN GLMN IL12A IL12A FGF17 FGF17 FGF18 FGF18 PDGFRB PDGFRB KL KL FGF6 FGF6 ITGB3 ITGB3 PDCL2 PDCL2 IL21 IL21 FYN FYN PDGFC PDGFC ESM1 ESM1 TNK2 TNK2 ERAP1 ERAP1 CD2AP CD2AP IL1F10 IL1F10 FGF20 FGF20 FER FER FGF4 FGF4 LINGO1 LINGO1 RNF41 RNF41 IL5 IL5 MS4A15 MS4A15 IL1RAP IL1RAP VEGFB VEGFB G3R9G9_GORGO G3R9G9_GORGO CCDC88A CCDC88A LYN LYN GRAP GRAP AGR2 AGR2 ADAM17 ADAM17 LINGO2 LINGO2 SHC1 SHC1 CD300LF CD300LF KLB KLB BTC BTC IL9 IL9 G3REU9_GORGO G3REU9_GORGO PGF PGF FGF8 FGF8 PDGFB PDGFB G3RIK8_GORGO G3RIK8_GORGO RNF126 RNF126 IL36G IL36G IL36A IL36A G3RIU1_GORGO G3RIU1_GORGO ARTN ARTN PYCARD PYCARD FGF1 FGF1 SRC SRC IL6 IL6 G3RS38_GORGO G3RS38_GORGO G3RSU6_GORGO G3RSU6_GORGO PLSCR1 PLSCR1 FGF3 FGF3 EFEMP1 EFEMP1 ECM1 ECM1 IRAK4 IRAK4 G3RZ13_GORGO G3RZ13_GORGO AREG AREG IL2 IL2 G3S382_GORGO G3S382_GORGO CNTF CNTF G3S653_GORGO G3S653_GORGO G3S6C5_GORGO G3S6C5_GORGO SOCS5 SOCS5 G3SAS0_GORGO G3SAS0_GORGO FLRT3 FLRT3 PIBF1 PIBF1 VAV2 VAV2 IL11 IL11 CDH5 CDH5 NRXN1 NRXN1 FRS2 FRS2 ENSGGOP00000030302 ENSGGOP00000030302 MS4A1 MS4A1 ENSGGOP00000030478 ENSGGOP00000030478 SNX1 SNX1 EPGN EPGN DAB2IP DAB2IP SDCBP SDCBP FLRT2 FLRT2 HIP1 HIP1 FGF2 FGF2 ENSGGOP00000033538 ENSGGOP00000033538 IL36RN IL36RN IL37 IL37 ENSGGOP00000035808 ENSGGOP00000035808 ENSGGOP00000036215 ENSGGOP00000036215 TSLP TSLP CADM4 CADM4 PDCL3 PDCL3 ENSGGOP00000038190 ENSGGOP00000038190 SNX4 SNX4 ENSGGOP00000041058 ENSGGOP00000041058 ERBB4 ERBB4 ENSGGOP00000045025 ENSGGOP00000045025 TGFA TGFA PTPRJ PTPRJ ENSGGOP00000045750 ENSGGOP00000045750 ENSGGOP00000047931 ENSGGOP00000047931 VAV3 VAV3 ENSGGOP00000048403 ENSGGOP00000048403 NCSTN NCSTN ENSGGOP00000049122 ENSGGOP00000049122 GDNF GDNF ENSGGOP00000050098 ENSGGOP00000050098 VEGFC VEGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFHeparin binding EGF like growth factor. (208 aa)
ARF4ADP ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
PSPNPersephin. (156 aa)
G3QDY6_GORGOInterleukin 7. (179 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
NPTNNeuroplastin. (367 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TRIP6Thyroid hormone receptor interactor 6. (476 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa)
FAM83BFamily with sequence similarity 83 member B. (1011 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MS4A4AMembrane spanning 4-domains A4A. (239 aa)
SNX2PX domain-containing protein. (402 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
G3QL78_GORGONa(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (334 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL6STFibronectin type-III domain-containing protein. (329 aa)
EREGEGF-like domain-containing protein. (222 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL1RNInterleukin-1. (180 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF3Colony stimulating factor 3. (207 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GATA3GATA binding protein 3. (444 aa)
G3QTT4_GORGONeurturin. (197 aa)
G3QU00_GORGOUncharacterized protein. (567 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
KLUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (739 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (837 aa)
PDCL2Phosducin like 2. (241 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
FYNTyrosine-protein kinase. (537 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ESM1Endothelial cell specific molecule 1. (184 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
ERAP1Aminopeptidase. (948 aa)
CD2APCD2 associated protein. (639 aa)
IL1F10Interleukin-1. (152 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
RNF41Ring finger protein 41. (317 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
MS4A15Membrane spanning 4-domains A15. (239 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
G3R9G9_GORGOToll interacting protein. (223 aa)
CCDC88ACoiled-coil domain containing 88A. (1870 aa)
LYNTyrosine-protein kinase. (512 aa)
GRAPGRB2 related adaptor protein. (217 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
SHC1SHC adaptor protein 1. (584 aa)
CD300LFCD300 molecule like family member f. (305 aa)
KLBKlotho beta. (1044 aa)
BTCBetacellulin. (178 aa)
IL9Interleukin 9. (144 aa)
G3REU9_GORGOMitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (456 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
G3RIK8_GORGOFibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
RNF126Ring finger protein 126. (285 aa)
IL36GInterleukin-1. (169 aa)
IL36AInterleukin-1. (158 aa)
G3RIU1_GORGOInterleukin 36 beta. (164 aa)
ARTNArtemin. (228 aa)
PYCARDPYD and CARD domain containing. (195 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SRCTyrosine-protein kinase. (542 aa)
IL6Interleukin 6. (234 aa)
G3RS38_GORGOPhosducin domain-containing protein. (234 aa)
G3RSU6_GORGOUncharacterized protein. (499 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
ECM1Uncharacterized protein. (540 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
G3RZ13_GORGOFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
AREGEGF-like domain-containing protein. (274 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
G3S382_GORGORING-type domain-containing protein. (300 aa)
CNTFCiliary neurotrophic factor. (200 aa)
G3S653_GORGOUncharacterized protein. (443 aa)
G3S6C5_GORGOCTCK domain-containing protein. (143 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
G3SAS0_GORGOAtaxin 2. (1122 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
IL11Interleukin 11. (199 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
NRXN1Neurexin 1. (1547 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
ENSGGOP00000030302PDZ domain-containing protein. (258 aa)
MS4A1Membrane spanning 4-domains A1. (297 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
SNX1Sorting nexin 1. (557 aa)
EPGNEpithelial mitogen. (154 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
SDCBPSyndecan binding protein. (318 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
HIP1Huntingtin interacting protein 1. (1015 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (258 aa)
ENSGGOP00000033538Uncharacterized protein. (167 aa)
IL36RNInterleukin-1. (155 aa)
IL37Interleukin-1. (218 aa)
ENSGGOP00000035808Uncharacterized protein. (272 aa)
ENSGGOP00000036215Phosducin domain-containing protein. (190 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
CADM4Cell adhesion molecule 4. (373 aa)
PDCL3Phosducin like 3. (239 aa)
ENSGGOP00000038190CCR4-NOT transcription complex subunit 9. (331 aa)
SNX4Sorting nexin 4. (450 aa)
ENSGGOP00000041058annotation not available (54 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ENSGGOP00000045025Phosducin domain-containing protein. (227 aa)
TGFATransforming growth factor alpha. (166 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1305 aa)
ENSGGOP00000045750annotation not available (218 aa)
ENSGGOP00000047931Uncharacterized protein. (94 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ENSGGOP00000048403Lep_receptor_Ig domain-containing protein. (92 aa)
NCSTNNicastrin. (721 aa)
ENSGGOP00000049122Uncharacterized protein. (305 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
ENSGGOP00000050098annotation not available (190 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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