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| | PLSCR4 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (329 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (743 aa) |
| | FCAR | Fc fragment of IgA receptor. (287 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (819 aa) |
| | G3QT76_GORGO | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | NFKBIL1 | NFKB inhibitor like 1. (381 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | PRPF8 | Pre-mRNA processing factor 8. (2335 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (422 aa) |
| | RTL8B | Retrotransposon Gag like 8B. (113 aa) |
| | CSF3 | Colony stimulating factor 3. (207 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1028 aa) |
| | CXCL9 | C-X-C motif chemokine. (125 aa) |
| | DEFA1B | DEFENSIN domain-containing protein. (94 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | CMPK2 | Uncharacterized protein. (59 aa) |
| | G3QN63_GORGO | DUF4939 domain-containing protein. (83 aa) |
| | G3QMP2_GORGO | Protein tyrosine phosphatase non-receptor type 22. (693 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | CXCL1 | C-X-C motif chemokine. (107 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | RARA | Uncharacterized protein. (624 aa) |
| | SPI1 | Spi-1 proto-oncogene. (271 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | SPON2 | Spondin 2. (331 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1054 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa) |
| | CARD16 | Caspase recruitment domain family member 16. (197 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa) |
| | G3QHL6_GORGO | Interleukin 1 receptor associated kinase 2. (538 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (273 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CSF2 | Colony stimulating factor 2. (144 aa) |
| | HAMP | Hepcidin antimicrobial peptide. (84 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (295 aa) |
| | G3QUW7_GORGO | TIR domain-containing adapter molecule 1. (563 aa) |
| | PDE4B | Phosphodiesterase. (736 aa) |
| | GFER | Sulfhydryl oxidase. (205 aa) |
| | G3QW36_GORGO | Uncharacterized protein. (652 aa) |
| | G3QW50_GORGO | BCR activator of RhoGEF and GTPase. (1101 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (402 aa) |
| | CEBPE | CCAAT/enhancer-binding protein. (281 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | G3QX42_GORGO | Bactericidal permeability increasing protein. (487 aa) |
| | G3QX51_GORGO | Lipopolysaccharide binding protein. (481 aa) |
| | G3QXA0_GORGO | SCY domain-containing protein. (53 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | G3QYC6_GORGO | Calpain 2; Belongs to the peptidase C2 family. (673 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (319 aa) |
| | EPHB2 | EPH receptor B2. (1113 aa) |
| | CD86 | CD86 molecule. (329 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (453 aa) |
| | CD6 | CD6 molecule. (675 aa) |
| | G3R063_GORGO | C-X-C motif chemokine. (103 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (599 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (614 aa) |
| | SHPK | FGGY_N domain-containing protein. (479 aa) |
| | CXCL6 | C-X-C motif chemokine. (114 aa) |
| | ASS1 | Argininosuccinate synthase 1. (412 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa) |
| | G3R467_GORGO | Translocator protein. (169 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | NLRP7 | NLR family pyrin domain containing 7. (1037 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | DEFA4 | Defensin alpha 4. (97 aa) |
| | DEFA6 | Defensin alpha 6. (100 aa) |
| | NUGGC | Nuclear GTPase, germinal center associated. (796 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1319 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | G3R9N8_GORGO | Uncharacterized protein. (458 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (759 aa) |
| | G3RAJ9_GORGO | Cyclin dependent kinase 19. (446 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | G3RBD1_GORGO | C-type lectin domain containing 17A. (341 aa) |
| | AKAP8 | A-kinase anchoring protein 8; Belongs to the AKAP95 family. (692 aa) |
| | G3RCP0_GORGO | HSF_DOMAIN domain-containing protein. (527 aa) |
| | G3RD46_GORGO | Cathepsin G; Belongs to the peptidase S1 family. (255 aa) |
| | CXCL13 | C-X-C motif chemokine. (109 aa) |
| | PTAFR | Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | IL10 | Interleukin 10. (178 aa) |
| | ZFP36 | ZFP36 ring finger protein. (332 aa) |
| | EDNRB | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa) |
| | FN1 | Fibronectin 1. (2477 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) |
| | G3RGP4_GORGO | Uncharacterized protein. (1212 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | PF4 | C-X-C motif chemokine. (101 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | IL36G | Interleukin-1. (169 aa) |
| | IL36A | Interleukin-1. (158 aa) |
| | G3RIU1_GORGO | Interleukin 36 beta. (164 aa) |
| | DEFA5 | Defensin alpha 5. (94 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | PLAA | Uncharacterized protein. (609 aa) |
| | G3RKU1_GORGO | Peroxisome proliferator activated receptor delta. (389 aa) |
| | NOS3 | Nitric oxide synthase 3. (997 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | EFNB2 | Ephrin B2; Belongs to the ephrin family. (336 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (376 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | TNFSF4 | TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa) |
| | G3RRK1_GORGO | Uncharacterized protein. (497 aa) |
| | ARG1 | Arginase. (322 aa) |
| | G3RRQ8_GORGO | AXL receptor tyrosine kinase. (843 aa) |
| | IL6 | Interleukin 6. (234 aa) |
| | GATA1 | GATA binding protein 1. (413 aa) |
| | IRGM | Immunity related GTPase M. (181 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TIRAP | TIR domain containing adaptor protein. (221 aa) |
| | CD80 | CD80 molecule. (287 aa) |
| | CCL3 | C-C motif chemokine. (92 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | TRIM41 | Tripartite motif containing 41. (612 aa) |
| | SIRPA | Signal regulatory protein alpha. (508 aa) |
| | ENSGGOP00000021036 | annotation not available (839 aa) |
| | PPBP | C-X-C motif chemokine. (128 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | CXCL3 | C-X-C motif chemokine. (107 aa) |
| | TBXA2R | Thromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa) |
| | IRF8 | Interferon regulatory factor 8. (426 aa) |
| | ADAMTS13 | ADAM metallopeptidase with thrombospondin type 1 motif 13. (1424 aa) |
| | FCGR2B | Uncharacterized protein. (310 aa) |
| | LY86 | Lymphocyte antigen 86. (162 aa) |
| | G3S9X9_GORGO | Uncharacterized protein. (384 aa) |
| | PF4V1 | C-X-C motif chemokine. (104 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | G3SAL4_GORGO | Uncharacterized protein. (201 aa) |
| | G3SAQ4_GORGO | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (66 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | G3SET6_GORGO | C-X-C motif chemokine. (107 aa) |
| | GSTP1 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa) |
| | FAM49B | Family with sequence similarity 49 member B. (324 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (486 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | G3SGN6_GORGO | Uncharacterized protein. (428 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (301 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | HCK | Tyrosine-protein kinase. (526 aa) |
| | CXCL5 | C-X-C motif chemokine. (114 aa) |
| | SLC7A5 | Solute carrier family 7 member 5. (507 aa) |
| | G3SJS6_GORGO | BPI fold containing family C. (466 aa) |
| | ARID5A | AT-rich interaction domain 5A. (594 aa) |
| | IL24 | Interleukin 24. (202 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa) |
| | ENSGGOP00000029719 | Uncharacterized protein. (223 aa) |
| | SELENOS | Uncharacterized protein. (218 aa) |
| | ENSGGOP00000030478 | Tyrosine-protein kinase. (1151 aa) |
| | ABCA1 | ATP binding cassette subfamily A member 1. (2264 aa) |
| | ENSGGOP00000031261 | Myocyte enhancer factor 2C. (483 aa) |
| | DAB2IP | DAB2 interacting protein. (1155 aa) |
| | ENSGGOP00000031506 | DEFENSIN domain-containing protein. (93 aa) |
| | ENSGGOP00000031801 | CCHC NOA-type domain-containing protein. (346 aa) |
| | CDC73 | Cell division cycle 73. (452 aa) |
| | CD68 | CD68 molecule. (354 aa) |
| | IL36RN | Interleukin-1. (155 aa) |
| | IL37 | Interleukin-1. (218 aa) |
| | MTDH | Metadherin. (612 aa) |
| | LITAF | Lipopolysaccharide induced TNF factor. (161 aa) |
| | ENSGGOP00000035751 | Uncharacterized protein. (406 aa) |
| | ENSGGOP00000035952 | TNF receptor-associated factor. (485 aa) |
| | ENSGGOP00000036779 | BCL2L2-PABPN1 readthrough. (346 aa) |
| | ENSGGOP00000037086 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (72 aa) |
| | ENSGGOP00000037129 | Uncharacterized protein. (233 aa) |
| | THPO | Thrombopoietin. (353 aa) |
| | CXCL11 | C-X-C motif chemokine. (94 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | XBP1 | BZIP domain-containing protein. (380 aa) |
| | ENSGGOP00000039123 | CCHC NOA-type domain-containing protein. (371 aa) |
| | ENSGGOP00000039332 | Uncharacterized protein. (334 aa) |
| | ENSGGOP00000040090 | Uncharacterized protein. (255 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | ENSGGOP00000041805 | RRM domain-containing protein. (268 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (533 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (645 aa) |
| | ENSGGOP00000043564 | Interferon regulatory factor 3. (452 aa) |
| | ENSGGOP00000044130 | RRM domain-containing protein. (251 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (345 aa) |
| | ENSGGOP00000045267 | Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa) |
| | ENSGGOP00000045750 | annotation not available (218 aa) |
| | ENSGGOP00000046207 | Uncharacterized protein. (404 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | ENSGGOP00000046735 | Non-specific serine/threonine protein kinase. (524 aa) |
| | ENSGGOP00000046758 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | CD274 | CD274 molecule. (303 aa) |
| | ENSGGOP00000049072 | Protein kinase domain-containing protein. (296 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | BCL10 | CARD domain-containing protein. (316 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (481 aa) |
| | AICDA | Activation induced cytidine deaminase. (199 aa) |
