(75 nodes) Stem cell proliferation network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD109	CD109 molecule. (1446 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	YAP1	Uncharacterized protein. (326 aa)
	G3QT48_GORGO	YjeF N-terminal domain containing 3. (299 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	OSR2	Odd-skipped related transciption factor 2. (422 aa)
	NF1	Neurofibromin 1. (2811 aa)
	RNF43	RING-type domain-containing protein. (783 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	ZNRF3	Zinc and ring finger 3. (879 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	SART3	Spliceosome associated factor 3, U4/U6 recycling protein. (963 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	MECOM	MDS1 and EVI1 complex locus. (1230 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (397 aa)
	NKAP	NFKB activating protein. (416 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
	SHB	SH2 domain containing adaptor protein B. (411 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	IRS2	Insulin receptor substrate 2. (1220 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	G3RNS2_GORGO	Short stature homeobox 2. (355 aa)
	G3RQI9_GORGO	WW domain-containing protein. (413 aa)
	OVOL1	Uncharacterized protein. (205 aa)
	HMX2	H6 family homeobox 2. (273 aa)
	SCRG1	Stimulator of chondrogenesis 1. (98 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1620 aa)
	LIG4	DNA ligase. (911 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	BABAM1	BRISC and BRCA1 A complex member 1. (329 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	CD34	CD34 molecule. (385 aa)
	ABCB1	ATP binding cassette subfamily B member 1. (1279 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	BYSL	Bystin like. (437 aa)
	BRCA2	BRCA2 DNA repair associated. (3416 aa)
	G3SIC3_GORGO	Uncharacterized protein. (337 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	CEP120	Centrosomal protein 120. (986 aa)
	SIX2	SIX homeobox 2. (291 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	PBX1	PBX homeobox 1. (430 aa)
	CEBPA	BZIP domain-containing protein. (141 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (596 aa)
	ENSGGOP00000042549	Uncharacterized protein. (75 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (488 aa)
	PTCH1	Patched 1. (1447 aa)
	ENSGGOP00000046487	TIA1 cytotoxic granule associated RNA binding protein like 1. (405 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	RUNX2	Runt domain-containing protein. (541 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (810 aa)
	IFT20	Intraflagellar transport 20. (158 aa)
	RARG	Retinoic acid receptor gamma. (451 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	ETV6	ETS variant 6. (452 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	HOXA3	Homeobox A3. (443 aa)
	CTC1	CST telomere replication complex component 1. (1217 aa)
	IRF6	Interferon regulatory factor 6. (467 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	AXIN2	Axin 2. (843 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB1	CTNNB1	ENSGGOP00000024624	ENSGGOP00000048898	ATP binding cassette subfamily B member 1.	Catenin beta 1.	0.465
ABCB1	LIG4	ENSGGOP00000024624	ENSGGOP00000022303	ATP binding cassette subfamily B member 1.	DNA ligase.	0.502
AXIN2	CTNNB1	ENSGGOP00000003901	ENSGGOP00000048898	Axin 2.	Catenin beta 1.	0.997
AXIN2	RNF43	ENSGGOP00000003901	ENSGGOP00000007083	Axin 2.	RING-type domain-containing protein.	0.601
AXIN2	SFRP2	ENSGGOP00000003901	ENSGGOP00000001672	Axin 2.	Secreted frizzled related protein 2.	0.640
AXIN2	SHH	ENSGGOP00000003901	ENSGGOP00000013669	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.431
AXIN2	SOX9	ENSGGOP00000003901	ENSGGOP00000016791	Axin 2.	SRY-box transcription factor 9.	0.460
AXIN2	WNT1	ENSGGOP00000003901	ENSGGOP00000010992	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.701
AXIN2	WNT10B	ENSGGOP00000003901	ENSGGOP00000010987	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.565
AXIN2	WNT11	ENSGGOP00000003901	ENSGGOP00000014664	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.580
AXIN2	WNT2B	ENSGGOP00000003901	ENSGGOP00000003551	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.549
AXIN2	WNT3	ENSGGOP00000003901	ENSGGOP00000006421	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.684
AXIN2	WNT5A	ENSGGOP00000003901	ENSGGOP00000007313	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.617
AXIN2	WNT7B	ENSGGOP00000003901	ENSGGOP00000036476	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.658
AXIN2	ZNRF3	ENSGGOP00000003901	ENSGGOP00000008101	Axin 2.	Zinc and ring finger 3.	0.454
BABAM1	BRCA2	ENSGGOP00000023556	ENSGGOP00000027226	BRISC and BRCA1 A complex member 1.	BRCA2 DNA repair associated.	0.530
BRCA2	BABAM1	ENSGGOP00000027226	ENSGGOP00000023556	BRCA2 DNA repair associated.	BRISC and BRCA1 A complex member 1.	0.530
BRCA2	ERCC2	ENSGGOP00000027226	ENSGGOP00000050930	BRCA2 DNA repair associated.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.646
BRCA2	LIG4	ENSGGOP00000027226	ENSGGOP00000022303	BRCA2 DNA repair associated.	DNA ligase.	0.656
BRCA2	NF1	ENSGGOP00000027226	ENSGGOP00000006859	BRCA2 DNA repair associated.	Neurofibromin 1.	0.530