STRINGSTRING
SFRP2 SFRP2 ENSGGOP00000039429 ENSGGOP00000039429 ILK ILK ENSGGOP00000041051 ENSGGOP00000041051 EGFR EGFR ZEB2 ZEB2 GPC3 GPC3 ENSGGOP00000042623 ENSGGOP00000042623 RBPJ RBPJ GPRC5B GPRC5B ENSGGOP00000043227 ENSGGOP00000043227 ENSGGOP00000043483 ENSGGOP00000043483 RNF146 RNF146 DAPK3 DAPK3 ENSGGOP00000043974 ENSGGOP00000043974 SMAD3 SMAD3 GID8 GID8 ENSGGOP00000047763 ENSGGOP00000047763 FZD9 FZD9 SFRP1 SFRP1 DKK2 DKK2 CSNK1G1 CSNK1G1 FRAT1 FRAT1 PPM1N PPM1N LRRK1 LRRK1 G3QCX1_GORGO G3QCX1_GORGO CDH3 CDH3 NLE1 NLE1 PPP2R3A PPP2R3A G3QFQ8_GORGO G3QFQ8_GORGO CCAR2 CCAR2 ZBED3 ZBED3 LGR5 LGR5 UBR5 UBR5 VCP VCP TMEM198 TMEM198 DLX5 DLX5 BAMBI BAMBI FGF10 FGF10 FGF9 FGF9 KANK1 KANK1 YAP1 YAP1 G3QSN9_GORGO G3QSN9_GORGO EGF EGF LGR6 LGR6 EDA EDA PIN1 PIN1 PLEKHA4 PLEKHA4 SMURF2 SMURF2 G3QW78_GORGO G3QW78_GORGO LYPD6 LYPD6 BIRC8 BIRC8 RSPO1 RSPO1 G3QXJ9_GORGO G3QXJ9_GORGO G3QZ51_GORGO G3QZ51_GORGO TRPM4 TRPM4 XIAP XIAP VPS35 VPS35 DAAM2 DAAM2 TBL1XR1 TBL1XR1 USP47 USP47 TNKS2 TNKS2 AMER1 AMER1 JUP JUP G3R4Q3_GORGO G3R4Q3_GORGO WNT10B WNT10B G3R6U4_GORGO G3R6U4_GORGO SEMA5A SEMA5A TNKS TNKS RPS12 RPS12 SOX4 SOX4 COL1A1 COL1A1 CTDNEP1 CTDNEP1 PPM1B PPM1B WNK2 WNK2 USP34 USP34 GPC5 GPC5 CSNK1G3 CSNK1G3 GSKIP GSKIP G3RQI9_GORGO G3RQI9_GORGO JRK JRK SRC SRC DACT1 DACT1 NFKB1 NFKB1 RSPO3 RSPO3 G3S0J3_GORGO G3S0J3_GORGO SFRP4 SFRP4 CAV1 CAV1 RSPO2 RSPO2 NRARP NRARP ASPM ASPM USP8 USP8 ATP6AP2 ATP6AP2 G3S9Z8_GORGO G3S9Z8_GORGO LGR4 LGR4 TGFB1 TGFB1 TTC21B TTC21B G3SGD7_GORGO G3SGD7_GORGO PPM1A PPM1A DDX3X DDX3X RECK RECK HHEX HHEX FAM53B FAM53B ENSGGOP00000030134 ENSGGOP00000030134 WLS WLS ENSGGOP00000032988 ENSGGOP00000032988 ENSGGOP00000033016 ENSGGOP00000033016 ENSGGOP00000033321 ENSGGOP00000033321 PTK7 PTK7 ARNTL ARNTL RNF220 RNF220 LRRK2 LRRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP2Secreted frizzled related protein 2. (295 aa)
ENSGGOP00000039429Uncharacterized protein. (266 aa)
ILKIntegrin linked kinase. (535 aa)
ENSGGOP00000041051Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1242 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1252 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
ENSGGOP00000042623Caprin family member 2. (1076 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
ENSGGOP00000043227Uncharacterized protein. (256 aa)
ENSGGOP00000043483FCP1 homology domain-containing protein. (218 aa)
RNF146Ring finger protein 146. (362 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
ENSGGOP00000043974Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (947 aa)
SMAD3Mothers against decapentaplegic homolog. (356 aa)
GID8GID complex subunit 8 homolog. (228 aa)
ENSGGOP00000047763WNK lysine deficient protein kinase 1. (2786 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
FRAT1FRAT regulator of WNT signaling pathway 1. (279 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
G3QCX1_GORGOCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
NLE1Notchless homolog 1. (485 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
G3QFQ8_GORGOSciellin. (671 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
ZBED3Zinc finger BED-type containing 3. (234 aa)
LGR5LRRNT domain-containing protein. (363 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2814 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
TMEM198Transmembrane protein 198. (360 aa)
DLX5Distal-less homeobox 5. (289 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
YAP1Uncharacterized protein. (326 aa)
G3QSN9_GORGOTransmembrane protein 9. (208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (955 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (270 aa)
PLEKHA4Pleckstrin homology domain containing A4. (692 aa)
SMURF2E3 ubiquitin-protein ligase. (750 aa)
G3QW78_GORGOProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
RSPO1R-spondin 1. (263 aa)
G3QXJ9_GORGOProtein kinase domain-containing protein. (352 aa)
G3QZ51_GORGOFibroblast growth factor receptor. (822 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1292 aa)
XIAPUncharacterized protein. (371 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
AMER1Uncharacterized protein. (805 aa)
JUPJunction plakoglobin. (745 aa)
G3R4Q3_GORGORuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (447 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
G3R6U4_GORGOPR/SET domain 15. (1368 aa)
SEMA5ASemaphorin 5A. (1041 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
SOX4Transcription factor SOX. (444 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)
WNK2WNK lysine deficient protein kinase 2. (2175 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3536 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
GSKIPGSK3B interacting protein. (139 aa)
G3RQI9_GORGOWW domain-containing protein. (413 aa)
JRKJrk helix-turn-helix protein. (556 aa)
SRCTyrosine-protein kinase. (542 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RSPO3R-spondin 3. (292 aa)
G3S0J3_GORGODUF4203 domain-containing protein. (106 aa)
SFRP4Secreted frizzled related protein 4. (368 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
RSPO2R-spondin 2. (250 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1118 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
G3S9Z8_GORGO40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (148 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (929 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
G3SGD7_GORGO40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (144 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
HHEXHomeobox domain-containing protein. (98 aa)
FAM53BFamily with sequence similarity 53 member B. (425 aa)
ENSGGOP00000030134Peptidyl-prolyl cis-trans isomerase. (155 aa)
WLSWnt ligand secretion mediator. (543 aa)
ENSGGOP00000032988annotation not available (98 aa)
ENSGGOP00000033016Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (419 aa)
ENSGGOP0000003332140S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (151 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
RNF220Ring finger protein 220. (566 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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