(22 nodes) Amyloid-beta clearance network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB11A	RAB11A, member RAS oncogene family. (216 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	LDLR	Low density lipoprotein receptor. (859 aa)
	C5AR1	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa)
	ENSGGOP00000034961	annotation not available (92 aa)
	ENSGGOP00000031306	Uncharacterized protein. (92 aa)
	RAB11B	Uncharacterized protein. (221 aa)
	C3	Complement C3. (1663 aa)
	LRP4	LDL receptor related protein 4. (1947 aa)
	G3QLK2_GORGO	LDL receptor related protein associated protein 1. (365 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (674 aa)
	G3R3Z1_GORGO	LDL receptor related protein 1. (4544 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
	G3R6K5_GORGO	ATP binding cassette subfamily A member 7. (2132 aa)
	ENSGGOP00000042710	Integrin beta. (813 aa)
	INSR	Tyrosine-protein kinase receptor. (1347 aa)
	LRP2	LDL receptor related protein 2. (4653 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	C5AR1	ENSGGOP00000024983	ENSGGOP00000038148	Complement C3.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.	0.854
C3	CD36	ENSGGOP00000024983	ENSGGOP00000005986	Complement C3.	CD36 molecule; Belongs to the CD36 family.	0.447
C3	ENSGGOP00000042710	ENSGGOP00000024983	ENSGGOP00000042710	Complement C3.	Integrin beta.	0.825
C3	ITGAM	ENSGGOP00000024983	ENSGGOP00000004003	Complement C3.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.995
C5AR1	C3	ENSGGOP00000038148	ENSGGOP00000024983	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.	Complement C3.	0.854
C5AR1	ITGAM	ENSGGOP00000038148	ENSGGOP00000004003	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.612
CD36	C3	ENSGGOP00000005986	ENSGGOP00000024983	CD36 molecule; Belongs to the CD36 family.	Complement C3.	0.447
CD36	ENSGGOP00000042710	ENSGGOP00000005986	ENSGGOP00000042710	CD36 molecule; Belongs to the CD36 family.	Integrin beta.	0.696
CD36	G3R3Z1_GORGO	ENSGGOP00000005986	ENSGGOP00000009976	CD36 molecule; Belongs to the CD36 family.	LDL receptor related protein 1.	0.613
CD36	ITGAM	ENSGGOP00000005986	ENSGGOP00000004003	CD36 molecule; Belongs to the CD36 family.	Integrin subunit alpha M; Belongs to the integrin alpha chain family.	0.622
CLTC	ENSGGOP00000031306	ENSGGOP00000007773	ENSGGOP00000031306	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.423
CLTC	ENSGGOP00000034961	ENSGGOP00000007773	ENSGGOP00000034961	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	annotation not available	0.423
CLTC	LRP2	ENSGGOP00000007773	ENSGGOP00000016227	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	LDL receptor related protein 2.	0.419
CLTC	LRP4	ENSGGOP00000007773	ENSGGOP00000018403	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	LDL receptor related protein 4.	0.419
CLTC	PICALM	ENSGGOP00000007773	ENSGGOP00000008931	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphatidylinositol binding clathrin assembly protein.	0.884
CLTC	RAB11A	ENSGGOP00000007773	ENSGGOP00000013901	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	RAB11A, member RAS oncogene family.	0.492
CLTC	RAB5A	ENSGGOP00000007773	ENSGGOP00000015584	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	RAB5A, member RAS oncogene family.	0.654
ENSGGOP00000031306	CLTC	ENSGGOP00000031306	ENSGGOP00000007773	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.423
ENSGGOP00000031306	RAB11B	ENSGGOP00000031306	ENSGGOP00000028164	Uncharacterized protein.	Uncharacterized protein.	0.644
ENSGGOP00000031306	RAB5A	ENSGGOP00000031306	ENSGGOP00000015584	Uncharacterized protein.	RAB5A, member RAS oncogene family.	0.775