76 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (988 aa)
	TRIP6	Thyroid hormone receptor interactor 6. (476 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	CCL19	C-C motif chemokine. (98 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	PHB2	Prohibitin. (299 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	CD27	CD27 molecule. (260 aa)
	TRIM44	Tripartite motif containing 44. (344 aa)
	G3QSI4_GORGO	Ring finger and CCCH-type domains 1. (1093 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	ACTN4	Actinin alpha 4. (931 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
	G3QT76_GORGO	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CCDC142	Coiled-coil domain containing 142. (743 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	EP300	E1A binding protein p300. (2416 aa)
	CD86	CD86 molecule. (329 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	IFI35	Interferon induced protein 35. (286 aa)
	NLRP12	NLR family pyrin domain containing 12. (1065 aa)
	RBCK1	Uncharacterized protein. (204 aa)
	G3R2M9_GORGO	Prohibitin. (194 aa)
	SASH1	SAM and SH3 domain containing 1. (1190 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	G3R5K1_GORGO	Ectodysplasin A receptor. (480 aa)
	TRADD	Death domain-containing protein. (251 aa)
	RHOA	Uncharacterized protein. (179 aa)
	IL18R1	Interleukin 18 receptor 1. (541 aa)
	EDN1	Endothelin 1. (212 aa)
	NMI	N-myc and STAT interactor. (307 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	CALR	Calreticulin. (417 aa)
	SPHK1	Sphingosine kinase 1. (472 aa)
	RTKN2	Rhotekin 2. (609 aa)
	C20H20orf27	Chromosome 20 open reading frame 27. (174 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (262 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	G3RNT3_GORGO	KH type-2 domain-containing protein. (250 aa)
	NFAT5	Nuclear factor of activated T cells 5. (1523 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
	G3RUI3_GORGO	Uncharacterized protein. (156 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	PHB	Prohibitin. (272 aa)
	G3S132_GORGO	Prohibitin. (230 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	G3S6C5_GORGO	CTCK domain-containing protein. (143 aa)
	TERF2IP	TERF2 interacting protein. (399 aa)
	TLR3	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (301 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
	LRRC19	Leucine rich repeat containing 19. (370 aa)
	ENSGGOP00000032772	Uncharacterized protein. (104 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	PTP4A3	Protein tyrosine phosphatase 4A3. (173 aa)
	ENSGGOP00000039304	KH type-2 domain-containing protein. (116 aa)
	ILK	Integrin linked kinase. (535 aa)
	ENSGGOP00000040205	Galectin. (355 aa)
	EGFR	Receptor protein-tyrosine kinase. (1205 aa)
	PDCD4	Programmed cell death 4. (469 aa)
	ENSGGOP00000043090	Prohibitin. (177 aa)
	ENSGGOP00000044168	Prohibitin. (258 aa)
	TCIM	Transcriptional and immune response regulator. (106 aa)
	ENSGGOP00000045096	KH type-2 domain-containing protein. (245 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (240 aa)
	ENSGGOP00000048900	Uncharacterized protein. (306 aa)
	APP	Amyloid beta precursor protein. (771 aa)
	ENSGGOP00000050319	Advanced glycosylation end-product specific receptor. (411 aa)
	ENSGGOP00000050644	Ribosomal_S3_C domain-containing protein. (100 aa)
	ENSGGOP00000051951	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN4	EGFR	ENSGGOP00000005783	ENSGGOP00000041101	Actinin alpha 4.	Receptor protein-tyrosine kinase.	0.698
ACTN4	RHOA	ENSGGOP00000005783	ENSGGOP00000012527	Actinin alpha 4.	Uncharacterized protein.	0.547
APP	CALR	ENSGGOP00000049928	ENSGGOP00000015732	Amyloid beta precursor protein.	Calreticulin.	0.793
APP	EDN1	ENSGGOP00000049928	ENSGGOP00000012971	Amyloid beta precursor protein.	Endothelin 1.	0.604
APP	EGFR	ENSGGOP00000049928	ENSGGOP00000041101	Amyloid beta precursor protein.	Receptor protein-tyrosine kinase.	0.726
APP	ENSGGOP00000050319	ENSGGOP00000049928	ENSGGOP00000050319	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.734
APP	EP300	ENSGGOP00000049928	ENSGGOP00000008032	Amyloid beta precursor protein.	E1A binding protein p300.	0.763
APP	G3QT76_GORGO	ENSGGOP00000049928	ENSGGOP00000005887	Amyloid beta precursor protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.608
APP	IL1B	ENSGGOP00000049928	ENSGGOP00000006245	Amyloid beta precursor protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.647
APP	RELA	ENSGGOP00000049928	ENSGGOP00000027696	Amyloid beta precursor protein.	RELA proto-oncogene, NF-kB subunit.	0.405
APP	TLR2	ENSGGOP00000049928	ENSGGOP00000003012	Amyloid beta precursor protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.450
APP	TREM2	ENSGGOP00000049928	ENSGGOP00000014711	Amyloid beta precursor protein.	Triggering receptor expressed on myeloid cells 2.	0.704
CALR	APP	ENSGGOP00000015732	ENSGGOP00000049928	Calreticulin.	Amyloid beta precursor protein.	0.793
CALR	ENSGGOP00000050319	ENSGGOP00000015732	ENSGGOP00000050319	Calreticulin.	Advanced glycosylation end-product specific receptor.	0.428
CALR	TLR2	ENSGGOP00000015732	ENSGGOP00000003012	Calreticulin.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.457
CD14	TLR2	ENSGGOP00000010116	ENSGGOP00000003012	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.978
CD14	TLR3	ENSGGOP00000010116	ENSGGOP00000027247	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.493
CD14	TLR7	ENSGGOP00000010116	ENSGGOP00000020624	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.502
CD27	CD86	ENSGGOP00000004555	ENSGGOP00000008390	CD27 molecule.	CD86 molecule.	0.835
CD27	ENSGGOP00000040205	ENSGGOP00000004555	ENSGGOP00000040205	CD27 molecule.	Galectin.	0.480