(15 nodes) Semaphorin-plexin signaling pathway involved in axon guidance network (Gorilla gorilla)

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Your Input:
	PLXNB3	Plexin B3. (1932 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1409 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (785 aa)
	PLXNA1	Plexin A1. (1917 aa)
	PLXNA3	Plexin A3. (1871 aa)
	EDN1	Endothelin 1. (212 aa)
	ECE1	Endothelin converting enzyme 1. (758 aa)
	PLXNA4	Plexin A4. (1854 aa)
	PLXNB2	Plexin B2. (1838 aa)
	PLXNB1	Plexin B1. (2135 aa)
	PLXNA2	Plexin A2. (1836 aa)
	PLXNC1	Plexin C1. (1637 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	PLXND1	Plexin D1. (1925 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ECE1	EDN1	ENSGGOP00000011799	ENSGGOP00000012971	Endothelin converting enzyme 1.	Endothelin 1.	0.867
ECE1	EDNRA	ENSGGOP00000011799	ENSGGOP00000000610	Endothelin converting enzyme 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.673
EDN1	ECE1	ENSGGOP00000012971	ENSGGOP00000011799	Endothelin 1.	Endothelin converting enzyme 1.	0.867
EDN1	EDNRA	ENSGGOP00000012971	ENSGGOP00000000610	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDNRA	ECE1	ENSGGOP00000000610	ENSGGOP00000011799	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin converting enzyme 1.	0.673
EDNRA	EDN1	ENSGGOP00000000610	ENSGGOP00000012971	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
MET	NRP1	ENSGGOP00000041736	ENSGGOP00000001478	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Neuropilin; Belongs to the neuropilin family.	0.572
MET	PLXNA1	ENSGGOP00000041736	ENSGGOP00000021744	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin A1.	0.711
MET	PLXNA2	ENSGGOP00000041736	ENSGGOP00000004340	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin A2.	0.711
MET	PLXNA3	ENSGGOP00000041736	ENSGGOP00000013167	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin A3.	0.711
MET	PLXNA4	ENSGGOP00000041736	ENSGGOP00000007005	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin A4.	0.711
MET	PLXNB1	ENSGGOP00000041736	ENSGGOP00000006110	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B1.	0.997
MET	PLXNB2	ENSGGOP00000041736	ENSGGOP00000006493	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B2.	0.965
MET	PLXNB3	ENSGGOP00000041736	ENSGGOP00000039636	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B3.	0.967
MET	PLXNC1	ENSGGOP00000041736	ENSGGOP00000002520	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin C1.	0.711
MET	PLXND1	ENSGGOP00000041736	ENSGGOP00000000725	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin D1.	0.711
MET	SEMA3F	ENSGGOP00000041736	ENSGGOP00000038614	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Semaphorin 3F; Belongs to the semaphorin family.	0.645
NRP1	MET	ENSGGOP00000001478	ENSGGOP00000041736	Neuropilin; Belongs to the neuropilin family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.572
NRP1	PLXNA1	ENSGGOP00000001478	ENSGGOP00000021744	Neuropilin; Belongs to the neuropilin family.	Plexin A1.	0.997
NRP1	PLXNA2	ENSGGOP00000001478	ENSGGOP00000004340	Neuropilin; Belongs to the neuropilin family.	Plexin A2.	0.996