STRINGSTRING
CREBRF CREBRF MANF MANF PPP1R15B PPP1R15B DDIT3 DDIT3 PDX1 PDX1 SYVN1 SYVN1 LPCAT3 LPCAT3 WFS1 WFS1 G3R6I2_GORGO G3R6I2_GORGO BBC3 BBC3 PIK3R1 PIK3R1 ENSGGOP00000048677 ENSGGOP00000048677 BCL2L11 BCL2L11 NUPR1 NUPR1 ERP29 ERP29 BOK BOK TMBIM6 TMBIM6 ENSGGOP00000042147 ENSGGOP00000042147 GRINA GRINA UBXN1 UBXN1 BAG6 BAG6 RNFT2 RNFT2 XBP1 XBP1 PRKN PRKN ATF6B ATF6B ATXN3 ATXN3 LRRK2 LRRK2 NFE2L2 NFE2L2 DDRGK1 DDRGK1 DAB2IP DAB2IP ENSGGOP00000031130 ENSGGOP00000031130 ENSGGOP00000031106 ENSGGOP00000031106 SELENOS SELENOS ENSGGOP00000029762 ENSGGOP00000029762 NCK2 NCK2 USP13 USP13 COPS5 COPS5 G3SDQ0_GORGO G3SDQ0_GORGO NCK1 NCK1 RNF185 RNF185 FCGR2B FCGR2B PTPN2 PTPN2 HSPA5 HSPA5 CAV1 CAV1 G3S1U3_GORGO G3S1U3_GORGO BCL2L1 BCL2L1 BAK1 BAK1 BFAR BFAR G3RPU5_GORGO G3RPU5_GORGO G3RMA5_GORGO G3RMA5_GORGO UBQLN2 UBQLN2 CLU CLU UBQLN1 UBQLN1 SVIP SVIP SERINC3 SERINC3 CREB3L1 CREB3L1 DNAJB9 DNAJB9 G3R8T5_GORGO G3R8T5_GORGO MBTPS2 MBTPS2 AQP11 AQP11 EIF2AK3 EIF2AK3 FICD FICD G3R6K5_GORGO G3R6K5_GORGO BAX BAX TXNDC12 TXNDC12 SIRT1 SIRT1 ALOX5 ALOX5 AGR2 AGR2 UFL1 UFL1 ATF6 ATF6 USP19 USP19 RNFT1 RNFT1 TMEM33 TMEM33 NR1H3 NR1H3 HYOU1 HYOU1 SGTA SGTA CREB3 CREB3 PTPN1 PTPN1 ERN1 ERN1 G3QTZ7_GORGO G3QTZ7_GORGO NR1H2 NR1H2 BCAP31 BCAP31 HERPUD1 HERPUD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREBRFCREB3 regulatory factor. (639 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (216 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (713 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity); Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. (284 aa)
SYVN1Synoviolin 1. (617 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
G3R6I2_GORGOTransmembrane protein 259. (543 aa)
BBC3Uncharacterized protein. (101 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
ENSGGOP00000048677Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (460 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
ERP29Endoplasmic reticulum protein 29. (302 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
TMBIM6Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (295 aa)
ENSGGOP00000042147Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1125 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1. (365 aa)
UBXN1UBX domain protein 1. (310 aa)
BAG6BCL2 associated athanogene 6. (1190 aa)
RNFT2Ring finger protein, transmembrane 2. (444 aa)
XBP1BZIP domain-containing protein. (380 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
ATXN3Ataxin 3. (366 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
DDRGK1DDRGK domain containing 1. (345 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
ENSGGOP00000031130Uncharacterized protein. (189 aa)
ENSGGOP00000031106WD_REPEATS_REGION domain-containing protein. (321 aa)
SELENOSUncharacterized protein. (218 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
NCK2Cytoplasmic protein. (380 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
G3SDQ0_GORGOUncharacterized protein. (240 aa)
NCK1Cytoplasmic protein. (377 aa)
RNF185Ring finger protein 185. (192 aa)
FCGR2BUncharacterized protein. (310 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (387 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
G3S1U3_GORGOOPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
BCL2L1BCL2 like 1. (233 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
BFARBifunctional apoptosis regulator. (450 aa)
G3RPU5_GORGOUncharacterized protein; Belongs to the heat shock protein 70 family. (613 aa)
G3RMA5_GORGOTyrosine-protein phosphatase non-receptor type. (415 aa)
UBQLN2Ubiquilin 2. (624 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
UBQLN1Ubiquilin 1. (589 aa)
SVIPSmall VCP interacting protein. (77 aa)
SERINC3Serine incorporator 3. (473 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
DNAJB9DnaJ heat shock protein family (Hsp40) member B9. (223 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (520 aa)
AQP11Aquaporin 11. (224 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1116 aa)
FICDFIC domain containing. (458 aa)
G3R6K5_GORGOATP binding cassette subfamily A member 7. (2132 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
TXNDC12Thioredoxin domain containing 12. (172 aa)
SIRT1Sirtuin 1. (751 aa)
ALOX5Arachidonate 5-lipoxygenase. (678 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
UFL1UFM1 specific ligase 1. (794 aa)
ATF6Activating transcription factor 6. (670 aa)
USP19Ubiquitin specific peptidase 19. (1421 aa)
RNFT1Ring finger protein, transmembrane 1. (435 aa)
TMEM33Transmembrane protein 33. (247 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
G3QTZ7_GORGOProtein phosphatase 1 regulatory subunit 15A. (682 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
BCAP31B cell receptor associated protein 31. (313 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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