STRINGSTRING
PLRG1 PLRG1 RFWD3 RFWD3 PPP2CA PPP2CA G3QDR0_GORGO G3QDR0_GORGO CUL4A CUL4A STIL STIL KMT2E KMT2E BCL2 BCL2 PTEN PTEN SASS6 SASS6 SMARCD3 SMARCD3 CPSF3 CPSF3 G3QIJ6_GORGO G3QIJ6_GORGO JADE1 JADE1 ZNF655 ZNF655 TERT TERT PKD2 PKD2 LSM10 LSM10 CASP2 CASP2 E2F1 E2F1 CDKN2D CDKN2D FGF10 FGF10 ANXA1 ANXA1 PRAP1 PRAP1 WEE1 WEE1 TFDP1 TFDP1 DLG1 DLG1 CRLF3 CRLF3 MEPCE MEPCE RBL1 RBL1 ZC3H12D ZC3H12D G3QTD2_GORGO G3QTD2_GORGO TREX1 TREX1 GPNMB GPNMB PKD1 PKD1 G3QVZ5_GORGO G3QVZ5_GORGO ADAMTS1 ADAMTS1 RBM38 RBM38 GIGYF2 GIGYF2 MNAT1 MNAT1 MUC1 MUC1 FBXO31 FBXO31 CCND2 CCND2 G3R2E0_GORGO G3R2E0_GORGO SDE2 SDE2 MTBP MTBP CDK2AP2 CDK2AP2 PDPN PDPN ATM ATM BID BID PRMT2 PRMT2 MBLAC1 MBLAC1 CUL4B CUL4B TM4SF5 TM4SF5 DDR2 DDR2 G3R7T7_GORGO G3R7T7_GORGO SMARCE1 SMARCE1 G3R8K9_GORGO G3R8K9_GORGO KCNA5 KCNA5 E2F7 E2F7 PLK2 PLK2 G3RAW2_GORGO G3RAW2_GORGO ADAM17 ADAM17 APPL2 APPL2 G3RBT3_GORGO G3RBT3_GORGO CDK7 CDK7 KIF14 KIF14 ARID2 ARID2 EIF4G1 EIF4G1 PTPN6 PTPN6 CENPJ CENPJ G3RFN1_GORGO G3RFN1_GORGO CCND3 CCND3 PHF10 PHF10 CDC6 CDC6 ACTL6A ACTL6A GFI1B GFI1B PBRM1 PBRM1 CCL2 CCL2 ECD ECD G3RJZ9_GORGO G3RJZ9_GORGO G3RK43_GORGO G3RK43_GORGO G3RK66_GORGO G3RK66_GORGO SMARCC1 SMARCC1 CDKN2C CDKN2C MYO16 MYO16 FBXO7 FBXO7 STOX1 STOX1 BCL7C BCL7C SMARCD2 SMARCD2 RPL26 RPL26 CTDSP2 CTDSP2 G3RN55_GORGO G3RN55_GORGO G3RNB7_GORGO G3RNB7_GORGO G3RPM5_GORGO G3RPM5_GORGO TRIAP1 TRIAP1 DACT1 DACT1 APC APC CDKN1A CDKN1A BCL7B BCL7B RGCC RGCC PLK3 PLK3 G3RWH6_GORGO G3RWH6_GORGO G3RWI0_GORGO G3RWI0_GORGO G3RXR2_GORGO G3RXR2_GORGO G3RZZ0_GORGO G3RZZ0_GORGO RDX RDX SMARCC2 SMARCC2 CRADD CRADD AMBRA1 AMBRA1 G3S4N5_GORGO G3S4N5_GORGO RRM1 RRM1 LSM11 LSM11 G3S7H0_GORGO G3S7H0_GORGO TFDP3 TFDP3 PSME2 PSME2 EZH2 EZH2 DPF3 DPF3 G3SCJ7_GORGO G3SCJ7_GORGO CTDSP1 CTDSP1 BRD7 BRD7 RPS27L RPS27L KLF4 KLF4 DDX3X DDX3X SLFN11 SLFN11 G3SKL0_GORGO G3SKL0_GORGO ENSGGOP00000028873 ENSGGOP00000028873 ENSGGOP00000029067 ENSGGOP00000029067 PIDD1 PIDD1 PPP2R5C PPP2R5C SMARCA2 SMARCA2 CDKN2A CDKN2A CDC73 CDC73 ENSGGOP00000032627 ENSGGOP00000032627 CCND1 CCND1 DPF2 DPF2 ARID1A ARID1A SMARCA4 SMARCA4 ENSGGOP00000035282 ENSGGOP00000035282 SMARCD1 SMARCD1 ENSGGOP00000036237 ENSGGOP00000036237 ENSGGOP00000036466 ENSGGOP00000036466 RRM2 RRM2 FHL1 FHL1 CTDSPL CTDSPL CDKN2B CDKN2B FAM107A FAM107A KANK2 KANK2 RPTOR RPTOR EGFR EGFR ACVR1 ACVR1 ENSGGOP00000041713 ENSGGOP00000041713 CACNB4 CACNB4 PSME3 PSME3 ENSGGOP00000042610 ENSGGOP00000042610 DGKZ DGKZ PSME1 PSME1 PLCB1 PLCB1 ANKRD17 ANKRD17 ENSGGOP00000043815 ENSGGOP00000043815 ENSGGOP00000043833 ENSGGOP00000043833 ENSGGOP00000043985 ENSGGOP00000043985 DCUN1D3 DCUN1D3 ENSGGOP00000045437 ENSGGOP00000045437 CCNH CCNH ENSGGOP00000046735 ENSGGOP00000046735 UBE2E2 UBE2E2 ENSGGOP00000047892 ENSGGOP00000047892 ENSGGOP00000048162 ENSGGOP00000048162 INHBA INHBA ENSGGOP00000048702 ENSGGOP00000048702 ENSGGOP00000049238 ENSGGOP00000049238 ENSGGOP00000049405 ENSGGOP00000049405 CDKN1B CDKN1B RBL2 RBL2 WAC WAC ENSGGOP00000050973 ENSGGOP00000050973 DPF1 DPF1 ENSGGOP00000051678 ENSGGOP00000051678 ENSGGOP00000051899 ENSGGOP00000051899 ENSGGOP00000051974 ENSGGOP00000051974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLRG1Pleiotropic regulator 1. (514 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
G3QDR0_GORGOUncharacterized protein. (486 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
STILSTIL centriolar assembly protein. (1242 aa)
KMT2ELysine methyltransferase 2E. (1858 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (699 aa)
G3QIJ6_GORGOBAF chromatin remodeling complex subunit BCL7A. (203 aa)
JADE1Jade family PHD finger 1. (842 aa)
ZNF655Zinc finger protein 655. (526 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
E2F1E2F transcription factor 1. (437 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ANXA1Annexin. (346 aa)
PRAP1Uncharacterized protein. (150 aa)
WEE1Wee1-like protein kinase. (646 aa)
TFDP1Transcription factor. (411 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
CRLF3Cytokine receptor like factor 3. (442 aa)
MEPCEMethylphosphate capping enzyme. (689 aa)
RBL1RB transcriptional corepressor like 1. (1066 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (527 aa)
G3QTD2_GORGOProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
GPNMBGlycoprotein nmb. (574 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3761 aa)
G3QVZ5_GORGOHyaluronidase. (435 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
RBM38Uncharacterized protein. (158 aa)
GIGYF2GRB10 interacting GYF protein 2. (1318 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
FBXO31F-box protein 31. (543 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
G3R2E0_GORGOUncharacterized protein. (258 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
MTBPMDM2 binding protein. (904 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (126 aa)
PDPNPodoplanin. (237 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (266 aa)
CUL4BCullin 4B; Belongs to the cullin family. (929 aa)
TM4SF5Transmembrane 4 L six family member 5. (197 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
G3R7T7_GORGOAT-rich interaction domain 1B. (2015 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
G3R8K9_GORGOAllograft inflammatory factor 1. (147 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
E2F7E2F transcription factor 7. (911 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
G3RAW2_GORGOPolo like kinase 5. (319 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
G3RBT3_GORGOUncharacterized protein. (1516 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
ARID2AT-rich interaction domain 2. (1834 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1603 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CENPJCentromere protein J. (1338 aa)
G3RFN1_GORGOUncharacterized protein. (344 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
PHF10PHD finger protein 10. (469 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
GFI1BGrowth factor independent 1B transcriptional repressor. (330 aa)
PBRM1Polybromo 1. (1665 aa)
CCL2C-C motif chemokine. (99 aa)
ECDEcdysoneless cell cycle regulator. (644 aa)
G3RJZ9_GORGORB transcriptional corepressor 1. (756 aa)
G3RK43_GORGOActin like 6B; Belongs to the actin family. (358 aa)
G3RK66_GORGOCytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1054 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
FBXO7F-box protein 7. (522 aa)
STOX1Storkhead box 1. (988 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (242 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
RPL26Ribosomal protein L26. (145 aa)
CTDSP2CTD small phosphatase 2. (271 aa)
G3RN55_GORGOUncharacterized protein. (258 aa)
G3RNB7_GORGOUncharacterized protein. (661 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BCL7BUncharacterized protein. (272 aa)
RGCCRegulator of cell cycle. (137 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
G3RWH6_GORGOTranscription factor 3. (673 aa)
G3RWI0_GORGOUncharacterized protein. (168 aa)
G3RXR2_GORGOHMG box domain-containing protein. (369 aa)
G3RZZ0_GORGOCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
RDXRadixin. (604 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
G3S4N5_GORGOCyclin dependent kinase 10. (315 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
LSM11LSM11, U7 small nuclear RNA associated. (360 aa)
G3S7H0_GORGOAdaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (646 aa)
TFDP3Transcription factor. (405 aa)
PSME2Proteasome activator subunit 2. (239 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
DPF3Double PHD fingers 3. (412 aa)
G3SCJ7_GORGOCNX domain-containing protein. (249 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
BRD7Bromodomain containing 7. (652 aa)
RPS27L40S ribosomal protein S27. (96 aa)
KLF4Kruppel like factor 4. (479 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
SLFN11Schlafen family member 11. (901 aa)
G3SKL0_GORGOSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (377 aa)
ENSGGOP00000028873Uncharacterized protein. (467 aa)
ENSGGOP00000029067KOW domain-containing protein. (138 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (472 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1510 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (167 aa)
CDC73Cell division cycle 73. (452 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (295 aa)
DPF2Double PHD fingers 2. (405 aa)
ARID1AAT-rich interaction domain 1A. (2258 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1689 aa)
ENSGGOP00000035282Bromo domain-containing protein. (601 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (477 aa)
ENSGGOP00000036237Uncharacterized protein. (377 aa)
ENSGGOP00000036466Checkpoint kinase 2. (529 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
FHL1Four and a half LIM domains 1. (323 aa)
CTDSPLCTD small phosphatase like. (263 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
FAM107AFamily with sequence similarity 107 member A. (175 aa)
KANK2KN motif and ankyrin repeat domains 2. (859 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1288 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
ENSGGOP00000041713Transmembrane protein 14B. (151 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
PSME3Proteasome activator subunit 3. (265 aa)
ENSGGOP00000042610Protein kinase domain-containing protein. (322 aa)
DGKZDiacylglycerol kinase. (1117 aa)
PSME1Uncharacterized protein. (216 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ANKRD17Ankyrin repeat domain 17. (2496 aa)
ENSGGOP00000043815Uncharacterized protein. (156 aa)
ENSGGOP00000043833FERM domain-containing protein. (517 aa)
ENSGGOP00000043985Uncharacterized protein. (195 aa)
DCUN1D3DCN1-like protein. (304 aa)
ENSGGOP00000045437Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (575 aa)
CCNHCyclin H; Belongs to the cyclin family. (329 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
ENSGGOP00000047892Uncharacterized protein. (262 aa)
ENSGGOP00000048162HMG box domain-containing protein. (352 aa)
INHBAInhibin subunit beta A. (426 aa)
ENSGGOP00000048702Uncharacterized protein. (400 aa)
ENSGGOP00000049238Uncharacterized protein. (383 aa)
ENSGGOP00000049405Uncharacterized protein. (233 aa)
CDKN1BUncharacterized protein. (205 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
WACWW domain containing adaptor with coiled-coil. (666 aa)
ENSGGOP00000050973Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
DPF1Double PHD fingers 1. (398 aa)
ENSGGOP00000051678Butyrophilin subfamily 2 member A2. (523 aa)
ENSGGOP00000051899FERM domain-containing protein. (488 aa)
ENSGGOP00000051974HMG box domain-containing protein. (359 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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