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| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (257 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (270 aa) |
| | HVCN1 | Hydrogen voltage gated channel 1. (274 aa) |
| | UCP1 | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) |
| | G3RR23_GORGO | Uncharacterized protein. (210 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | G3RSR8_GORGO | Haptoglobin; Belongs to the peptidase S1 family. (371 aa) |
| | G3RSU6_GORGO | Uncharacterized protein. (499 aa) |
| | G3RT18_GORGO | Uncharacterized protein. (179 aa) |
| | G3RT65_GORGO | Sphingosine kinase 2. (663 aa) |
| | ENSGGOP00000051997 | C-type lectin domain containing 7A. (247 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (481 aa) |
| | ENSGGOP00000050768 | Paired box 2. (392 aa) |
| | ENSGGOP00000050281 | Protein kinase domain-containing protein. (338 aa) |
| | THBS1 | Thrombospondin 1. (1173 aa) |
| | HDAC6 | Histone deacetylase 6. (1218 aa) |
| | SLC18A2 | Solute carrier family 18 member A2. (514 aa) |
| | ENSGGOP00000049072 | Protein kinase domain-containing protein. (296 aa) |
| | ENSGGOP00000048792 | Uncharacterized protein. (199 aa) |
| | SLC5A3 | Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa) |
| | ENSGGOP00000048540 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | ENSGGOP00000048104 | annotation not available (264 aa) |
| | ENSGGOP00000047330 | Uncharacterized protein. (261 aa) |
| | ROMO1 | Reactive oxygen species modulator 1. (79 aa) |
| | ENSGGOP00000043736 | Aldo-keto reductase family 1 member C2. (323 aa) |
| | CRYAB | Crystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa) |
| | ENSGGOP00000042710 | Integrin beta. (813 aa) |
| | DHFR | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa) |
| | TRAP1 | TNF receptor associated protein 1. (718 aa) |
| | ENSGGOP00000041746 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (85 aa) |
| | SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (280 aa) |
| | PON2 | Uncharacterized protein. (375 aa) |
| | G3S0S1_GORGO | Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (581 aa) |
| | PRDX2 | Peroxiredoxin 2. (198 aa) |
| | SLC25A33 | Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa) |
| | CRP | Pentaxin. (224 aa) |
| | G3S523_GORGO | Beta-carotene oxygenase 2. (533 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa) |
| | FOXM1 | Forkhead box M1. (763 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (560 aa) |
| | MPV17 | Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | GSTP1 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (337 aa) |
| | SNCA | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | G3SIL0_GORGO | Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1570 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (850 aa) |
| | G3SK08_GORGO | Uncharacterized protein. (877 aa) |
| | CD177 | Uncharacterized protein. (144 aa) |
| | ENSGGOP00000029762 | DJ-1_PfpI domain-containing protein. (168 aa) |
| | ENSGGOP00000030315 | Fibulin 5. (506 aa) |
| | ENSGGOP00000031272 | Cytochrome c oxidase assembly factor 8. (206 aa) |
| | ENSGGOP00000032712 | Uncharacterized protein. (264 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (600 aa) |
| | ENSGGOP00000033982 | Uncharacterized protein. (256 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | ENSGGOP00000034402 | Uncharacterized protein. (278 aa) |
| | ENSGGOP00000035220 | Thioredoxin domain-containing protein. (136 aa) |
| | ENSGGOP00000036910 | Uncharacterized protein. (80 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) |
| | ENSGGOP00000038710 | Uncharacterized protein. (216 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (468 aa) |
| | ARF4 | ADP ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | PARL | Presenilin associated rhomboid like. (379 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | BECN1 | Beclin 1. (450 aa) |
| | G3QHC9_GORGO | Glutamate ionotropic receptor NMDA type subunit 1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (814 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa) |
| | COQ7 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa) |
| | CBR1 | Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | G3QKE2_GORGO | Aldo-keto reductase family 1 member C3. (323 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | G3QMJ4_GORGO | Bone morphogenetic protein 7. (380 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | G3QQC9_GORGO | Glucose-6-phosphate dehydrogenase. (561 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (745 aa) |
| | ARG2 | Arginase. (354 aa) |
| | MT3 | Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa) |
| | G3QT76_GORGO | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | PDK3 | Protein-serine/threonine kinase. (423 aa) |
| | HK2 | Hexokinase 2. (917 aa) |
| | F2 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa) |
| | MPV17L | Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (127 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | F2RL1 | F2R like trypsin receptor 1. (397 aa) |
| | TUSC2 | Tumor suppressor 2, mitochondrial calcium regulator. (110 aa) |
| | G3QW50_GORGO | BCR activator of RhoGEF and GTPase. (1101 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | ACE2 | Angiotensin-converting enzyme. (805 aa) |
| | TFAP2A | Transcription factor AP-2 alpha. (439 aa) |
| | PID1 | Phosphotyrosine interaction domain containing 1. (250 aa) |
| | PAGE1 | PAGE family member 1. (146 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | MMP8 | Matrix metallopeptidase 8. (467 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (599 aa) |
| | ABCD2 | ATP binding cassette subfamily D member 2. (740 aa) |
| | SLC30A10 | Solute carrier family 30 member 10. (485 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (400 aa) |
| | G3R3J0_GORGO | NADPH oxidase 5. (767 aa) |
| | G3R467_GORGO | Translocator protein. (169 aa) |
| | MMP3 | Matrix metallopeptidase 3. (477 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (289 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | G3R664_GORGO | Uncharacterized protein. (226 aa) |
| | RNF41 | Ring finger protein 41. (317 aa) |
| | XDH | Xanthine dehydrogenase. (1333 aa) |
| | G3R7I7_GORGO | Dicarbonyl and L-xylulose reductase. (244 aa) |
| | DUOXA2 | Dual oxidase maturation factor 2. (320 aa) |
| | DUOXA1 | Dual oxidase maturation factor 1. (484 aa) |
| | ZNF205 | Zinc finger protein 205. (554 aa) |
| | G3R8T5_GORGO | Parkinsonism associated deglycase. (155 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (325 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (678 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | PIKFYVE | Phosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa) |
| | PON3 | Paraoxonase 3. (354 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | CLCN3 | Chloride channel protein. (866 aa) |
| | RAB27A | RAB27A, member RAS oncogene family. (221 aa) |
| | BNIP3 | Uncharacterized protein. (194 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | G3RG73_GORGO | CD177 molecule. (415 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | ABCB7 | ATP binding cassette subfamily B member 7. (753 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | PRCP | Prolylcarboxypeptidase. (517 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
