STRINGSTRING
ITGA5 ITGA5 TLE1 TLE1 BCL2 BCL2 SNAI2 SNAI2 G3QGV2_GORGO G3QGV2_GORGO PDK4 PDK4 PIK3CA PIK3CA NOTCH1 NOTCH1 NTRK2 NTRK2 MCL1 MCL1 SRC SRC PIK3R3 PIK3R3 CEACAM6 CEACAM6 BCL2L1 BCL2L1 PTK2 PTK2 CAV1 CAV1 PTRH2 PTRH2 ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
G3QGV2_GORGOZinc finger protein 304. (706 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOTCH1Uncharacterized protein. (1606 aa)
NTRK2Tyrosine-protein kinase receptor. (767 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R3Uncharacterized protein. (507 aa)
CEACAM6Carcinoembryonic antigen related cell adhesion molecule 6. (344 aa)
BCL2L1BCL2 like 1. (233 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
PTRH2Peptidyl-tRNA hydrolase 2. (180 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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