STRINGSTRING
ENSGGOP00000051951 ENSGGOP00000051951 AGT AGT IL20RA IL20RA G3QDR0_GORGO G3QDR0_GORGO S100A9 S100A9 PTEN PTEN FLCN FLCN BECN1 BECN1 PLEKHF1 PLEKHF1 DDIT3 DDIT3 CTSC CTSC ZSWIM2 ZSWIM2 ITM2C ITM2C TAF6 TAF6 PRKCD PRKCD G3QL78_GORGO G3QL78_GORGO RET RET CASP2 CASP2 IL19 IL19 G3QP21_GORGO G3QP21_GORGO RIPK3 RIPK3 GSDME GSDME BCAP31 BCAP31 PRKRA PRKRA G3QT76_GORGO G3QT76_GORGO MAL MAL HTRA2 HTRA2 RPS3 RPS3 PPP2R1A PPP2R1A NOX1 NOX1 NF1 NF1 HYAL2 HYAL2 TRAF2 TRAF2 G3QY09_GORGO G3QY09_GORGO SEPTIN4 SEPTIN4 NGFR NGFR CYLD CYLD FIS1 FIS1 NFATC4 NFATC4 RBCK1 RBCK1 MSX1 MSX1 G3R3B3_GORGO G3R3B3_GORGO G3R3C0_GORGO G3R3C0_GORGO SIRT1 SIRT1 G3R428_GORGO G3R428_GORGO BAX BAX BID BID LTBR LTBR BMPR1B BMPR1B G3R8T5_GORGO G3R8T5_GORGO CTSH CTSH RIPK1 RIPK1 ADORA2A ADORA2A TIMP3 TIMP3 FAF1 FAF1 G3RC81_GORGO G3RC81_GORGO STK4 STK4 ATF3 ATF3 INHBB INHBB SERINC3 SERINC3 MCL1 MCL1 G3RJV6_GORGO G3RJV6_GORGO CLU CLU PYCARD PYCARD IFNB1 IFNB1 G3RMA5_GORGO G3RMA5_GORGO RPL26 RPL26 G3RNB7_GORGO G3RNB7_GORGO G3RNL1_GORGO G3RNL1_GORGO G3RNT3_GORGO G3RNT3_GORGO VNN3 VNN3 TRAF7 TRAF7 G3RPM5_GORGO G3RPM5_GORGO MYC MYC G3RSK3_GORGO G3RSK3_GORGO G3RV54_GORGO G3RV54_GORGO FADD FADD RPL11 RPL11 S100A8 S100A8 SRPX SRPX SKIL SKIL SFPQ SFPQ CRADD CRADD RPS7 RPS7 CAV1 CAV1 CTNNA1 CTNNA1 G3S4X5_GORGO G3S4X5_GORGO MAPK9 MAPK9 SIAH1 SIAH1 PTPN2 PTPN2 PDIA3 PDIA3 NCK1 NCK1 BCLAF1 BCLAF1 FBXW7 FBXW7 FAS FAS ENSGGOP00000027573 ENSGGOP00000027573 ENSGGOP00000029067 ENSGGOP00000029067 BCL2L14 BCL2L14 NCK2 NCK2 ENSGGOP00000052231 ENSGGOP00000052231 ENSGGOP00000029762 ENSGGOP00000029762 TPD52L1 TPD52L1 ENSGGOP00000030478 ENSGGOP00000030478 ENSGGOP00000030811 ENSGGOP00000030811 ENSGGOP00000031106 ENSGGOP00000031106 PEA15 PEA15 PLAGL2 PLAGL2 DAB2IP DAB2IP ENSGGOP00000031909 ENSGGOP00000031909 LCK LCK PAK2 PAK2 ENSGGOP00000032772 ENSGGOP00000032772 NKX3-1 NKX3-1 ENSGGOP00000034350 ENSGGOP00000034350 APAF1 APAF1 ENSGGOP00000039096 ENSGGOP00000039096 ENSGGOP00000039304 ENSGGOP00000039304 TNFSF12 TNFSF12 BAD BAD ENSGGOP00000040139 ENSGGOP00000040139 G0S2 G0S2 TP63 TP63 ENSGGOP00000041843 ENSGGOP00000041843 ENSGGOP00000042743 ENSGGOP00000042743 SOD1 SOD1 ENSGGOP00000044043 ENSGGOP00000044043 ENSGGOP00000044467 ENSGGOP00000044467 ENSGGOP00000045096 ENSGGOP00000045096 ENSGGOP00000045475 ENSGGOP00000045475 ENSGGOP00000045477 ENSGGOP00000045477 BOK BOK STK3 STK3 G3RF33_GORGO G3RF33_GORGO NUPR1 NUPR1 BCL2L11 BCL2L11 INHBA INHBA WWOX WWOX SFRP1 SFRP1 FBH1 FBH1 EEF1E1 EEF1E1 ENSGGOP00000049802 ENSGGOP00000049802 THBS1 THBS1 BBC3 BBC3 ENSGGOP00000050644 ENSGGOP00000050644 ENSGGOP00000051050 ENSGGOP00000051050 AGTR2 AGTR2 TGFBR1 TGFBR1 BCL10 BCL10 DEDD2 DEDD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGGOP00000051951KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
IL20RAInterleukin 20 receptor subunit alpha. (553 aa)
G3QDR0_GORGOUncharacterized protein. (486 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FLCNFolliculin. (579 aa)
BECN1Beclin 1. (450 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (279 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
ZSWIM2Zinc finger SWIM-type containing 2. (633 aa)
ITM2CIntegral membrane protein 2C. (267 aa)
TAF6TATA-box binding protein associated factor 6. (714 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
G3QL78_GORGONa(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (334 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
IL19Interleukin 19. (215 aa)
G3QP21_GORGOVanin 1. (513 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
GSDMEGasdermin E. (496 aa)
BCAP31B cell receptor associated protein 31. (313 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (313 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MALMal, T cell differentiation protein. (153 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
NOX1NADPH oxidase 1. (564 aa)
NF1Neurofibromin 1. (2811 aa)
HYAL2Hyaluronidase. (473 aa)
TRAF2TNF receptor-associated factor. (451 aa)
G3QY09_GORGOProtein inhibitor of activated STAT 4. (510 aa)
SEPTIN4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1012 aa)
NGFRNerve growth factor receptor. (427 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
NFATC4Nuclear factor of activated T cells 4. (920 aa)
RBCK1Uncharacterized protein. (204 aa)
MSX1Msh homeobox 1. (303 aa)
G3R3B3_GORGOCell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa)
G3R3C0_GORGOSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SIRT1Sirtuin 1. (751 aa)
G3R428_GORGOProtein phosphatase 2 scaffold subunit Abeta. (620 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
LTBRLymphotoxin beta receptor. (435 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
FAF1Fas associated factor 1. (650 aa)
G3RC81_GORGOF-box and WD repeat domain containing 9. (478 aa)
STK4Serine/threonine kinase 4. (487 aa)
ATF3Activating transcription factor 3. (181 aa)
INHBBInhibin subunit beta B. (407 aa)
SERINC3Serine incorporator 3. (473 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
G3RJV6_GORGOTripartite motif containing 39. (518 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IFNB1Interferon beta 1. (187 aa)
G3RMA5_GORGOTyrosine-protein phosphatase non-receptor type. (415 aa)
RPL26Ribosomal protein L26. (145 aa)
G3RNB7_GORGOUncharacterized protein. (661 aa)
G3RNL1_GORGOUncharacterized protein. (448 aa)
G3RNT3_GORGOKH type-2 domain-containing protein. (250 aa)
VNN3CN hydrolase domain-containing protein. (501 aa)
TRAF7TNF receptor associated factor 7. (670 aa)
G3RPM5_GORGOPromyelocytic leukemia. (834 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
G3RSK3_GORGO40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (206 aa)
G3RV54_GORGOProtein tyrosine phosphatase receptor type C. (1306 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
RPL11Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
SRPXSushi repeat containing protein X-linked. (464 aa)
SKILSKI like proto-oncogene. (684 aa)
SFPQSplicing factor proline and glutamine rich. (590 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
CTNNA1Catenin alpha 1. (906 aa)
G3S4X5_GORGOMAGE family member D1. (834 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (387 aa)
PDIA3Protein disulfide-isomerase. (383 aa)
NCK1Cytoplasmic protein. (377 aa)
BCLAF1BCL2 associated transcription factor 1. (920 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
FASFas cell surface death receptor. (340 aa)
ENSGGOP00000027573annotation not available (93 aa)
ENSGGOP00000029067KOW domain-containing protein. (138 aa)
BCL2L14BCL2 like 14. (360 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSGGOP00000052231Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (167 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
TPD52L1TPD52 like 1. (209 aa)
ENSGGOP00000030478Tyrosine-protein kinase. (1151 aa)
ENSGGOP00000030811Uncharacterized protein. (145 aa)
ENSGGOP00000031106WD_REPEATS_REGION domain-containing protein. (321 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
PLAGL2PLAG1 like zinc finger 2. (496 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
ENSGGOP00000031909Serine/threonine/tyrosine interacting like 1. (313 aa)
LCKTyrosine-protein kinase. (524 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ENSGGOP00000032772Uncharacterized protein. (104 aa)
NKX3-1NK3 homeobox 1. (234 aa)
ENSGGOP00000034350Uncharacterized protein. (492 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP0000003909640S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (177 aa)
ENSGGOP00000039304KH type-2 domain-containing protein. (116 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ENSGGOP00000040139Uncharacterized protein. (86 aa)
G0S2G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. (103 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSGGOP00000041843G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ENSGGOP00000042743ING domain-containing protein. (174 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ENSGGOP00000044043Uncharacterized protein. (100 aa)
ENSGGOP00000044467Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
ENSGGOP00000045096KH type-2 domain-containing protein. (245 aa)
ENSGGOP00000045475Uncharacterized protein. (799 aa)
ENSGGOP00000045477Non-specific serine/threonine protein kinase. (530 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
STK3Serine/threonine kinase 3. (519 aa)
G3RF33_GORGOTumor necrosis factor ligand superfamily member. (281 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
INHBAInhibin subunit beta A. (426 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FBH1F-box DNA helicase 1. (1096 aa)
EEF1E1GST C-terminal domain-containing protein. (179 aa)
ENSGGOP0000004980240S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (192 aa)
THBS1Thrombospondin 1. (1173 aa)
BBC3Uncharacterized protein. (101 aa)
ENSGGOP00000050644Ribosomal_S3_C domain-containing protein. (100 aa)
ENSGGOP0000005105040S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (187 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
BCL10CARD domain-containing protein. (316 aa)
DEDD2Death effector domain containing 2. (330 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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