STRINGSTRING
RNF34 RNF34 SH3RF1 SH3RF1 G3QDY6_GORGO G3QDY6_GORGO CX3CL1 CX3CL1 IFI6 IFI6 BCL2 BCL2 LMNA LMNA SNAI2 SNAI2 CSF2 CSF2 AGAP2 AGAP2 NRP1 NRP1 SFRP2 SFRP2 PHIP PHIP BMP5 BMP5 TERT TERT CTTN CTTN EYA1 EYA1 TNFAIP3 TNFAIP3 LGALS3 LGALS3 IL1A IL1A RFFL RFFL IL19 IL19 COL2A1 COL2A1 FGF10 FGF10 MAP2K5 MAP2K5 IGF1 IGF1 PAK5 PAK5 IL4 IL4 YAP1 YAP1 ARHGEF2 ARHGEF2 G3QT76_GORGO G3QT76_GORGO MAPK7 MAPK7 IL1B IL1B ITPRIPL2 ITPRIPL2 GCLC GCLC TMBIM1 TMBIM1 SERPINE1 SERPINE1 GSK3B GSK3B CFLAR CFLAR FAIM FAIM G3R8T5_GORGO G3R8T5_GORGO NOL3 NOL3 RIPK1 RIPK1 GPX1 GPX1 PELI3 PELI3 EYA4 EYA4 FGB FGB SIAH2 SIAH2 BMP4 BMP4 G3RGU7_GORGO G3RGU7_GORGO ZC3HC1 ZC3HC1 PF4 PF4 MCL1 MCL1 GCLM GCLM HTT HTT NOS3 NOS3 SGK3 SGK3 G3RQI9_GORGO G3RQI9_GORGO SRC SRC GATA1 GATA1 RPS6KB1 RPS6KB1 UNC5B UNC5B BCL2L1 BCL2L1 PRDX2 PRDX2 EYA3 EYA3 GFRAL GFRAL CTNNA1 CTNNA1 BRCA1 BRCA1 RB1CC1 RB1CC1 ENSGGOP00000024523 ENSGGOP00000024523 FGA FGA FAIM2 FAIM2 GSTP1 GSTP1 RAF1 RAF1 RELA RELA DDX3X DDX3X EYA2 EYA2 ENSGGOP00000029762 ENSGGOP00000029762 PEA15 PEA15 FGG FGG AR AR ENSGGOP00000035220 ENSGGOP00000035220 HGF HGF ICAM1 ICAM1 ENSGGOP00000039692 ENSGGOP00000039692 ACVR1 ACVR1 NRG1 NRG1 ENSGGOP00000042047 ENSGGOP00000042047 TCF7L2 TCF7L2 PSME3 PSME3 ITGAV ITGAV ITGA6 ITGA6 STRADB STRADB ENSGGOP00000045214 ENSGGOP00000045214 ENSGGOP00000045725 ENSGGOP00000045725 ENSGGOP00000045863 ENSGGOP00000045863 HMOX1 HMOX1 ENSGGOP00000046735 ENSGGOP00000046735 ENSGGOP00000047637 ENSGGOP00000047637 BIRC6 BIRC6 GDNF GDNF THBS1 THBS1 TGFBR1 TGFBR1 ENSGGOP00000051392 ENSGGOP00000051392
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF34RING-type domain-containing protein. (500 aa)
SH3RF1SH3 domain containing ring finger 1. (887 aa)
G3QDY6_GORGOInterleukin 7. (179 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
IFI6Interferon alpha inducible protein 6. (130 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CSF2Colony stimulating factor 2. (144 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1080 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
PHIPPleckstrin homology domain interacting protein. (1810 aa)
BMP5TGF_BETA_2 domain-containing protein. (133 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
CTTNCortactin. (634 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
LGALS3Galectin. (267 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (363 aa)
IL19Interleukin 19. (215 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
IGF1IlGF domain-containing protein. (196 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
YAP1Uncharacterized protein. (326 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
G3QT76_GORGOTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ITPRIPL2ITPRIP like 2. (535 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
FAIMFas apoptotic inhibitory molecule. (201 aa)
G3R8T5_GORGOParkinsonism associated deglycase. (155 aa)
NOL3Nucleolar protein 3. (287 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
FGBFibrinogen beta chain. (491 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
G3RGU7_GORGOUncharacterized protein. (251 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
PF4C-X-C motif chemokine. (101 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
HTTHuntingtin. (3071 aa)
NOS3Nitric oxide synthase 3. (997 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
G3RQI9_GORGOWW domain-containing protein. (413 aa)
SRCTyrosine-protein kinase. (542 aa)
GATA1GATA binding protein 1. (413 aa)
RPS6KB1Protein kinase domain-containing protein. (210 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
BCL2L1BCL2 like 1. (233 aa)
PRDX2Peroxiredoxin 2. (198 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
GFRALGDNF family receptor alpha like. (394 aa)
CTNNA1Catenin alpha 1. (906 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ENSGGOP00000024523annotation not available (408 aa)
FGAFibrinogen alpha chain. (866 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (630 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
ENSGGOP00000029762DJ-1_PfpI domain-containing protein. (168 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
FGGFibrinogen gamma chain. (453 aa)
ARAndrogen receptor. (902 aa)
ENSGGOP00000035220Thioredoxin domain-containing protein. (136 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (733 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (532 aa)
ENSGGOP00000039692Glutathione peroxidase; Belongs to the glutathione peroxidase family. (130 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
NRG1Neuregulin 1. (713 aa)
ENSGGOP00000042047Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
TCF7L2HMG box domain-containing protein. (296 aa)
PSME3Proteasome activator subunit 3. (265 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1002 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
STRADBSTE20 related adaptor beta. (419 aa)
ENSGGOP00000045214Fib_alpha domain-containing protein. (288 aa)
ENSGGOP00000045725Zinc finger MYND-type containing 11. (645 aa)
ENSGGOP00000045863Protein kinase domain-containing protein. (393 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (289 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
ENSGGOP00000047637Inositol 1,4,5-trisphosphate receptor interacting protein. (547 aa)
BIRC6Baculoviral IAP repeat containing 6. (4883 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
THBS1Thrombospondin 1. (1173 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ENSGGOP00000051392CTNNB1_binding domain-containing protein. (452 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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