(35 nodes) Phagocytic vesicle membrane network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	SLC11A1	Solute carrier family 11 member 1. (550 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (472 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (888 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (997 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
	ENSGGOP00000050647	Uncharacterized protein; Belongs to the synaptobrevin family. (214 aa)
	ATP6V0E2	ATPase H+ transporting V0 subunit e2. (213 aa)
	ENSGGOP00000036972	Uncharacterized protein. (78 aa)
	LAMP1	Lysosomal associated membrane protein 1. (465 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	ATP6V0E1	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	ENSGGOP00000033024	Longin domain-containing protein; Belongs to the synaptobrevin family. (170 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	VAMP3	Vesicle associated membrane protein 3. (100 aa)
	ATP7A	ATPase copper transporting alpha. (1500 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	HVCN1	Hydrogen voltage gated channel 1. (274 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
	CALR	Calreticulin. (417 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	CLEC4E	C-type lectin domain family 4 member E. (219 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1159 aa)
	G3R5I2_GORGO	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (690 aa)
	ANXA3	Annexin. (325 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL2	ENSGGOP00000036972	ENSGGOP00000012832	ENSGGOP00000036972	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.757
APPL2	RAB31	ENSGGOP00000012832	ENSGGOP00000027737	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB31, member RAS oncogene family.	0.757
ATP6V0A2	ATP6V0A4	ENSGGOP00000008746	ENSGGOP00000008602	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.989
ATP6V0A2	ATP6V0B	ENSGGOP00000008746	ENSGGOP00000050846	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.995
ATP6V0A2	ATP6V0C	ENSGGOP00000008746	ENSGGOP00000018286	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.995
ATP6V0A2	ATP6V0E1	ENSGGOP00000008746	ENSGGOP00000006557	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.871
ATP6V0A2	ATP6V0E2	ENSGGOP00000008746	ENSGGOP00000043463	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit e2.	0.834
ATP6V0A2	G3R5I2_GORGO	ENSGGOP00000008746	ENSGGOP00000010559	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.968
ATP6V0A2	TCIRG1	ENSGGOP00000008746	ENSGGOP00000004910	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.988
ATP6V0A4	ATP6V0A2	ENSGGOP00000008602	ENSGGOP00000008746	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.989
ATP6V0A4	ATP6V0B	ENSGGOP00000008602	ENSGGOP00000050846	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.996
ATP6V0A4	ATP6V0C	ENSGGOP00000008602	ENSGGOP00000018286	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
ATP6V0A4	ATP6V0E1	ENSGGOP00000008602	ENSGGOP00000006557	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.933
ATP6V0A4	ATP6V0E2	ENSGGOP00000008602	ENSGGOP00000043463	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V0 subunit e2.	0.892
ATP6V0A4	G3R5I2_GORGO	ENSGGOP00000008602	ENSGGOP00000010559	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.943
ATP6V0A4	TCIRG1	ENSGGOP00000008602	ENSGGOP00000004910	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.989
ATP6V0B	ATP6V0A2	ENSGGOP00000050846	ENSGGOP00000008746	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.995
ATP6V0B	ATP6V0A4	ENSGGOP00000050846	ENSGGOP00000008602	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.996
ATP6V0B	ATP6V0C	ENSGGOP00000050846	ENSGGOP00000018286	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6V0B	ATP6V0E1	ENSGGOP00000050846	ENSGGOP00000006557	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.970