27 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOL3	Nucleolar protein 3. (287 aa)
	CARD16	Caspase recruitment domain family member 16. (197 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	CARD18	Caspase recruitment domain family member 18. (90 aa)
	CARD6	Caspase recruitment domain family member 6. (1037 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (604 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	NLRP1	NLR family pyrin domain containing 1. (1471 aa)
	G3R8R1_GORGO	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
	CASP5	Caspase 5; Belongs to the peptidase C14A family. (447 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	CARD14	Caspase recruitment domain family member 14. (1004 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	G3S2A2_GORGO	Caspase recruitment domain family member 10. (1028 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	ENSGGOP00000032091	Caspase 4; Belongs to the peptidase C14A family. (377 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	ENSGGOP00000045267	Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
	ENSGGOP00000046758	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	ENSGGOP00000048129	Caspase recruitment domain family member 9. (536 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	CARD8	Caspase recruitment domain family member 8. (522 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC2	ENSGGOP00000035421	ENSGGOP00000008137	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.796
APAF1	BIRC3	ENSGGOP00000035421	ENSGGOP00000005705	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 3.	0.758
APAF1	CARD16	ENSGGOP00000035421	ENSGGOP00000002111	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 16.	0.737
APAF1	CARD18	ENSGGOP00000035421	ENSGGOP00000003060	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 18.	0.766
APAF1	CARD8	ENSGGOP00000035421	ENSGGOP00000000255	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 8.	0.720
APAF1	CASP2	ENSGGOP00000035421	ENSGGOP00000003520	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.866
APAF1	CASP5	ENSGGOP00000035421	ENSGGOP00000015374	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 5; Belongs to the peptidase C14A family.	0.728
APAF1	CASP9	ENSGGOP00000035421	ENSGGOP00000001932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CRADD	ENSGGOP00000035421	ENSGGOP00000021798	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.568
APAF1	ENSGGOP00000032091	ENSGGOP00000035421	ENSGGOP00000032091	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 4; Belongs to the peptidase C14A family.	0.741
APAF1	ENSGGOP00000045267	ENSGGOP00000035421	ENSGGOP00000045267	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.720
APAF1	ENSGGOP00000046758	ENSGGOP00000035421	ENSGGOP00000046758	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 1; Belongs to the peptidase C14A family.	0.852
APAF1	G3R8R1_GORGO	ENSGGOP00000035421	ENSGGOP00000011776	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.	0.723
APAF1	NLRC4	ENSGGOP00000035421	ENSGGOP00000002707	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NLR family CARD domain containing 4.	0.590
APAF1	NLRP1	ENSGGOP00000035421	ENSGGOP00000011186	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NLR family pyrin domain containing 1.	0.562
APAF1	NOD1	ENSGGOP00000035421	ENSGGOP00000022426	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Nucleotide binding oligomerization domain containing 1.	0.591
APAF1	NOD2	ENSGGOP00000035421	ENSGGOP00000010525	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Nucleotide binding oligomerization domain containing 2.	0.526
APAF1	PYCARD	ENSGGOP00000035421	ENSGGOP00000016734	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	PYD and CARD domain containing.	0.466
APAF1	RIPK2	ENSGGOP00000035421	ENSGGOP00000010569	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.484
BCL10	BIRC2	ENSGGOP00000051225	ENSGGOP00000008137	CARD domain-containing protein.	Baculoviral IAP repeat containing 2.	0.661