STRINGSTRING
NLRP4 NLRP4 NLRP11 NLRP11 IFIH1 IFIH1 MEFV MEFV CASP5 CASP5 DEDD2 DEDD2 BCL10 BCL10 ENSGGOP00000048129 ENSGGOP00000048129 CARD11 CARD11 TNFRSF10A TNFRSF10A ENSGGOP00000046758 ENSGGOP00000046758 EDARADD EDARADD PYDC2 PYDC2 NLRP6 NLRP6 ENSGGOP00000045267 ENSGGOP00000045267 UNC5A UNC5A DTHD1 DTHD1 TNFRSF21 TNFRSF21 ENSGGOP00000039722 ENSGGOP00000039722 UNC5D UNC5D TTC3 TTC3 ANK1 ANK1 DEDD DEDD APAF1 APAF1 ENSGGOP00000033404 ENSGGOP00000033404 TNFRSF11B TNFRSF11B ENSGGOP00000032091 ENSGGOP00000032091 ENSGGOP00000031193 ENSGGOP00000031193 PEA15 PEA15 PIDD1 PIDD1 G3R3U7_GORGO G3R3U7_GORGO NLRP7 NLRP7 NOD2 NOD2 RIPK2 RIPK2 G3R5K1_GORGO G3R5K1_GORGO CFLAR CFLAR TNFRSF10B TNFRSF10B LRRD1 LRRD1 NLRP1 NLRP1 TRADD TRADD G3R8R1_GORGO G3R8R1_GORGO UNC5CL UNC5CL UNC5C UNC5C NOL3 NOL3 CASP10 CASP10 PYHIN1 PYHIN1 RIPK1 RIPK1 DAPK1 DAPK1 CARD8 CARD8 NLRP14 NLRP14 G3QHL6_GORGO G3QHL6_GORGO CASP9 CASP9 CARD16 CARD16 NLRC4 NLRC4 NLRP8 NLRP8 THOC1 THOC1 CARD18 CARD18 ANKDD1A ANKDD1A CARD6 CARD6 CASP2 CASP2 MYD88 MYD88 ANK3 ANK3 NLRP3 NLRP3 BIRC3 BIRC3 MNDA MNDA IFI16 IFI16 AIM2 AIM2 NFKB2 NFKB2 NLRP2 NLRP2 NLRP13 NLRP13 BIRC2 BIRC2 NGFR NGFR NLRP12 NLRP12 NLRP10 NLRP10 ENSGGOP00000029367 ENSGGOP00000029367 FAS FAS TNFRSF1A TNFRSF1A G3SE49_GORGO G3SE49_GORGO DDX58 DDX58 G3S5J8_GORGO G3S5J8_GORGO ANK2 ANK2 NOD1 NOD1 G3S2A2_GORGO G3S2A2_GORGO CRADD CRADD IRAK4 IRAK4 UNC5B UNC5B MALT1 MALT1 CARD14 CARD14 FADD FADD NFKB1 NFKB1 IRAK1 IRAK1 PYCARD PYCARD IGFLR1 IGFLR1 CARD19 CARD19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NLRP4NLR family pyrin domain containing 4. (992 aa)
NLRP11NLR family pyrin domain containing 11. (952 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
MEFVMEFV innate immuity regulator, pyrin. (781 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (447 aa)
DEDD2Death effector domain containing 2. (330 aa)
BCL10CARD domain-containing protein. (316 aa)
ENSGGOP00000048129Caspase recruitment domain family member 9. (536 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
EDARADDEDAR associated death domain. (215 aa)
PYDC2Pyrin domain-containing protein. (97 aa)
NLRP6Uncharacterized protein. (912 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
UNC5AUnc-5 netrin receptor A. (920 aa)
DTHD1Death domain containing 1. (906 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
ENSGGOP00000039722TNF receptor superfamily member 25. (426 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
TTC3Tetratricopeptide repeat domain 3. (2025 aa)
ANK1Ankyrin 1. (1897 aa)
DEDDDeath effector domain containing. (318 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
TNFRSF11BDeath domain-containing protein. (301 aa)
ENSGGOP00000032091Caspase 4; Belongs to the peptidase C14A family. (377 aa)
ENSGGOP00000031193Uncharacterized protein. (93 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
G3R3U7_GORGOMitochondrial antiviral signaling protein. (481 aa)
NLRP7NLR family pyrin domain containing 7. (1037 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
G3R5K1_GORGOEctodysplasin A receptor. (480 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
LRRD1Leucine rich repeats and death domain containing 1. (860 aa)
NLRP1NLR family pyrin domain containing 1. (1471 aa)
TRADDDeath domain-containing protein. (251 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
NOL3Nucleolar protein 3. (287 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
PYHIN1Pyrin and HIN domain family member 1. (492 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DAPK1Death associated protein kinase 1. (1397 aa)
CARD8Caspase recruitment domain family member 8. (522 aa)
NLRP14NLR family pyrin domain containing 14. (1093 aa)
G3QHL6_GORGOInterleukin 1 receptor associated kinase 2. (538 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
CARD16Caspase recruitment domain family member 16. (197 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
NLRP8NLR family pyrin domain containing 8. (1048 aa)
THOC1THO complex 1. (660 aa)
CARD18Caspase recruitment domain family member 18. (90 aa)
ANKDD1AAnkyrin repeat and death domain containing 1A. (522 aa)
CARD6Caspase recruitment domain family member 6. (1037 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
ANK3Ankyrin 3. (4378 aa)
NLRP3NLR family pyrin domain containing 3. (1028 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MNDAMyeloid cell nuclear differentiation antigen. (407 aa)
IFI16Interferon gamma inducible protein 16. (785 aa)
AIM2Absent in melanoma 2. (343 aa)
NFKB2Nuclear factor kappa B subunit 2. (902 aa)
NLRP2NLR family pyrin domain containing 2. (1040 aa)
NLRP13NLR family pyrin domain containing 13. (1036 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
NGFRNerve growth factor receptor. (427 aa)
NLRP12NLR family pyrin domain containing 12. (1065 aa)
NLRP10NLR family pyrin domain containing 10. (661 aa)
ENSGGOP00000029367Pyrin domain-containing protein. (110 aa)
FASFas cell surface death receptor. (340 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
G3SE49_GORGONLR family pyrin domain containing 9. (934 aa)
DDX58DExD/H-box helicase 58. (925 aa)
G3S5J8_GORGONLR family pyrin domain containing 5. (1194 aa)
ANK2Ankyrin 2. (3957 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
G3S2A2_GORGOCaspase recruitment domain family member 10. (1028 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
MALT1MALT1 paracaspase. (824 aa)
CARD14Caspase recruitment domain family member 14. (1004 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IGFLR1IGF like family receptor 1. (356 aa)
CARD19Caspase recruitment domain family member 19. (183 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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