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PDCD11 PDCD11 G3QDJ6_GORGO G3QDJ6_GORGO PSMC4 PSMC4 EIF2S1 EIF2S1 MRPS12 MRPS12 MCM7 MCM7 G3QK95_GORGO G3QK95_GORGO RPS11 RPS11 TTC14 TTC14 NARS2 NARS2 G3QN95_GORGO G3QN95_GORGO YBX1 YBX1 MCM3 MCM3 RMI2 RMI2 SRBD1 SRBD1 MNDA MNDA MCM4 MCM4 IFI16 IFI16 AIM2 AIM2 DIS3 DIS3 PSMC5 PSMC5 PNPT1 PNPT1 RNGTT RNGTT G3QZU9_GORGO G3QZU9_GORGO HELZ2 HELZ2 ZCCHC17 ZCCHC17 PSMC2 PSMC2 NARS1 NARS1 SSBP1 SSBP1 MCM5 MCM5 MRPL2 MRPL2 EXOSC2 EXOSC2 PSMC1 PSMC1 POLR2G POLR2G EIF1AD EIF1AD EIF5A EIF5A DDIAS DDIAS MEIOB MEIOB PYHIN1 PYHIN1 MCM10 MCM10 RPA1 RPA1 SPOUT1 SPOUT1 POT1 POT1 MCM2 MCM2 LIG1 LIG1 RPA2 RPA2 PSMC3 PSMC3 SUPT6H SUPT6H RADX RADX DARS2 DARS2 G3RT71_GORGO G3RT71_GORGO LIG3 LIG3 RPS28 RPS28 G3RUZ5_GORGO G3RUZ5_GORGO AIMP1 AIMP1 G3S060_GORGO G3S060_GORGO LIG4 LIG4 G3S2R7_GORGO G3S2R7_GORGO G3S8E4_GORGO G3S8E4_GORGO YBX3 YBX3 RPA3 RPA3 DIS3L2 DIS3L2 DHX8 DHX8 BRCA2 BRCA2 ENSGGOP00000029175 ENSGGOP00000029175 MRPS17 MRPS17 ENSGGOP00000029516 ENSGGOP00000029516 DARS1 DARS1 ENSGGOP00000031133 ENSGGOP00000031133 ENSGGOP00000031459 ENSGGOP00000031459 YARS1 YARS1 ENSGGOP00000032393 ENSGGOP00000032393 EIF5A2 EIF5A2 ENSGGOP00000035045 ENSGGOP00000035045 CARHSP1 CARHSP1 YBX2 YBX2 ENSGGOP00000036545 ENSGGOP00000036545 ENSGGOP00000036577 ENSGGOP00000036577 ENSGGOP00000036968 ENSGGOP00000036968 PSMC6 PSMC6 STN1 STN1 KARS1 KARS1 EXOSC3 EXOSC3 ENSGGOP00000038972 ENSGGOP00000038972 ENSGGOP00000039716 ENSGGOP00000039716 LIN28B LIN28B ENSGGOP00000040146 ENSGGOP00000040146 RPL8 RPL8 ENSGGOP00000042130 ENSGGOP00000042130 ENSGGOP00000042892 ENSGGOP00000042892 ENSGGOP00000043086 ENSGGOP00000043086 LIN28A LIN28A ENSGGOP00000044650 ENSGGOP00000044650 CSDE1 CSDE1 ENSGGOP00000045531 ENSGGOP00000045531 ENSGGOP00000045976 ENSGGOP00000045976 NABP1 NABP1 MCM6 MCM6 ENSGGOP00000048407 ENSGGOP00000048407 CCAR1 CCAR1 RPS23 RPS23 EXOSC1 EXOSC1 NABP2 NABP2 DIS3L DIS3L POLR3H POLR3H ENSGGOP00000050749 ENSGGOP00000050749
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDCD11Programmed cell death 11. (1871 aa)
G3QDJ6_GORGOOB domain-containing protein. (169 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
MRPS12Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family. (138 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
G3QK95_GORGODNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (125 aa)
RPS11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (158 aa)
TTC14Tetratricopeptide repeat domain 14. (770 aa)
NARS2Asparaginyl-tRNA synthetase 2, mitochondrial. (477 aa)
G3QN95_GORGOMinichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1095 aa)
YBX1Y-box binding protein 1. (324 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
SRBD1S1 RNA binding domain 1. (977 aa)
MNDAMyeloid cell nuclear differentiation antigen. (407 aa)
MCM4DNA helicase; Belongs to the MCM family. (861 aa)
IFI16Interferon gamma inducible protein 16. (785 aa)
AIM2Absent in melanoma 2. (343 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
RNGTTPolynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (600 aa)
G3QZU9_GORGOMinichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (880 aa)
HELZ2Helicase with zinc finger 2. (2653 aa)
ZCCHC17Zinc finger CCHC-type containing 17. (263 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
NARS1Asparaginyl-tRNA synthetase. (548 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MRPL2Mitochondrial ribosomal protein L2. (305 aa)
EXOSC2Exosome component 2. (293 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
EIF1ADEukaryotic translation initiation factor 1A domain containing. (166 aa)
EIF5AEukaryotic translation initiation factor 5A. (184 aa)
DDIASDNA damage induced apoptosis suppressor. (998 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
PYHIN1Pyrin and HIN domain family member 1. (492 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (876 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (585 aa)
SPOUT1SPOUT domain containing methyltransferase 1. (376 aa)
POT1Protection of telomeres 1. (634 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
LIG1DNA ligase. (895 aa)
RPA2Replication protein A2. (270 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
RADXRPA1 related single stranded DNA binding protein, X-linked. (855 aa)
DARS2Aspartyl-tRNA synthetase 2, mitochondrial. (645 aa)
G3RT71_GORGOCSD_1 domain-containing protein. (318 aa)
LIG3DNA ligase. (1009 aa)
RPS28Ribosomal protein S28. (69 aa)
G3RUZ5_GORGOS1-like domain-containing protein. (157 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
G3S060_GORGOEukaryotic translation initiation factor 5A. (148 aa)
LIG4DNA ligase. (911 aa)
G3S2R7_GORGOCSP domain-containing protein. (280 aa)
G3S8E4_GORGOCSP domain-containing protein. (314 aa)
YBX3Y-box binding protein 3. (373 aa)
RPA3Replication protein A3. (121 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (811 aa)
DHX8DEAH-box helicase 8. (1220 aa)
BRCA2BRCA2 DNA repair associated. (3416 aa)
ENSGGOP00000029175S1-like domain-containing protein. (162 aa)
MRPS17Uncharacterized protein. (130 aa)
ENSGGOP00000029516Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (129 aa)
DARS1Aspartyl-tRNA synthetase. (501 aa)
ENSGGOP00000031133Uncharacterized protein. (373 aa)
ENSGGOP00000031459AAA domain-containing protein. (407 aa)
YARS1Tyrosine--tRNA ligase. (555 aa)
ENSGGOP00000032393eIF-5a domain-containing protein. (82 aa)
EIF5A2Eukaryotic translation initiation factor 5A. (153 aa)
ENSGGOP00000035045S1-like domain-containing protein; Belongs to the eIF-1A family. (138 aa)
CARHSP1Calcium regulated heat stable protein 1. (147 aa)
YBX2Y-box binding protein 2. (374 aa)
ENSGGOP00000036545RPA_C domain-containing protein. (228 aa)
ENSGGOP00000036577AAA domain-containing protein. (340 aa)
ENSGGOP00000036968Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (131 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
KARS1Lysine--tRNA ligase. (629 aa)
EXOSC3Exosome component 3. (275 aa)
ENSGGOP00000038972AAA domain-containing protein. (392 aa)
ENSGGOP00000039716AAA domain-containing protein. (354 aa)
LIN28BLin-28 homolog B. (258 aa)
ENSGGOP00000040146CCHC-type domain-containing protein. (203 aa)
RPL8Ribosomal protein L8. (257 aa)
ENSGGOP00000042130Uncharacterized protein. (112 aa)
ENSGGOP00000042892Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (126 aa)
ENSGGOP00000043086S1 motif domain-containing protein. (716 aa)
LIN28ALin-28 homolog A. (209 aa)
ENSGGOP00000044650Cold shock domain containing C2. (153 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSGGOP00000045531Uncharacterized protein. (111 aa)
ENSGGOP00000045976Uncharacterized protein. (180 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ENSGGOP00000048407Uncharacterized protein. (125 aa)
CCAR1Cell division cycle and apoptosis regulator 1. (1150 aa)
RPS23Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (143 aa)
EXOSC1Exosome component 1. (170 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1079 aa)
POLR3HRNA polymerase III subunit H. (230 aa)
ENSGGOP00000050749AAA domain-containing protein. (395 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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