node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BIRC8 | ENSGGOP00000035421 | ENSGGOP00000007398 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | 0.849 |
APAF1 | CASP3 | ENSGGOP00000035421 | ENSGGOP00000021659 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 3; Belongs to the peptidase C14A family. | 0.995 |
APAF1 | CASP7 | ENSGGOP00000035421 | ENSGGOP00000045233 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 7; Belongs to the peptidase C14A family. | 0.895 |
APAF1 | CASP9 | ENSGGOP00000035421 | ENSGGOP00000001932 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYCS | ENSGGOP00000035421 | ENSGGOP00000028382 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | ENSGGOP00000031996 | ENSGGOP00000035421 | ENSGGOP00000031996 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.876 |
APAF1 | ENSGGOP00000049412 | ENSGGOP00000035421 | ENSGGOP00000049412 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.986 |
APAF1 | G3RLK9_GORGO | ENSGGOP00000035421 | ENSGGOP00000016660 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.993 |
APAF1 | G3RQE7_GORGO | ENSGGOP00000035421 | ENSGGOP00000018020 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.987 |
APAF1 | G3S8N2_GORGO | ENSGGOP00000035421 | ENSGGOP00000024445 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.876 |
APAF1 | G3SAG0_GORGO | ENSGGOP00000035421 | ENSGGOP00000025083 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.876 |
APAF1 | G3SDM2_GORGO | ENSGGOP00000035421 | ENSGGOP00000026202 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.876 |
APAF1 | XIAP | ENSGGOP00000035421 | ENSGGOP00000008442 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.849 |
BIRC8 | APAF1 | ENSGGOP00000007398 | ENSGGOP00000035421 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.849 |
BIRC8 | CASP3 | ENSGGOP00000007398 | ENSGGOP00000021659 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Caspase 3; Belongs to the peptidase C14A family. | 0.997 |
BIRC8 | CASP7 | ENSGGOP00000007398 | ENSGGOP00000045233 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Caspase 7; Belongs to the peptidase C14A family. | 0.997 |
BIRC8 | CASP9 | ENSGGOP00000007398 | ENSGGOP00000001932 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Caspase 9; Belongs to the peptidase C14A family. | 0.997 |
BIRC8 | CYCS | ENSGGOP00000007398 | ENSGGOP00000028382 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.628 |
BIRC8 | ENSGGOP00000031996 | ENSGGOP00000007398 | ENSGGOP00000031996 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.425 |
BIRC8 | ENSGGOP00000049412 | ENSGGOP00000007398 | ENSGGOP00000049412 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.460 |