(16 nodes) MAPK1 (ERK2) activation network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGGOP00000036103	Uncharacterized protein. (509 aa)
	ENSGGOP00000037095	Uncharacterized protein. (575 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	ENSGGOP00000048403	Lep_receptor_Ig domain-containing protein. (92 aa)
	G3R0F2_GORGO	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	TYK2	Tyrosine-protein kinase. (1188 aa)
	IL6ST	Fibronectin type-III domain-containing protein. (329 aa)
	IL6R	Interleukin 6 receptor. (468 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	G3RNM7_GORGO	Protein kinase domain-containing protein. (405 aa)
	G3RRP1_GORGO	Uncharacterized protein. (270 aa)
	IL6	Interleukin 6. (234 aa)
	ENSGGOP00000049122	Uncharacterized protein. (305 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	ENSGGOP00000030478	Tyrosine-protein kinase. (1151 aa)
	ENSGGOP00000034163	Uncharacterized protein. (485 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000030478	ENSGGOP00000034163	ENSGGOP00000030478	ENSGGOP00000034163	Tyrosine-protein kinase.	Uncharacterized protein.	0.881
ENSGGOP00000030478	ENSGGOP00000036103	ENSGGOP00000030478	ENSGGOP00000036103	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	ENSGGOP00000037095	ENSGGOP00000030478	ENSGGOP00000037095	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	ENSGGOP00000048403	ENSGGOP00000030478	ENSGGOP00000048403	Tyrosine-protein kinase.	Lep_receptor_Ig domain-containing protein.	0.480
ENSGGOP00000030478	ENSGGOP00000049122	ENSGGOP00000030478	ENSGGOP00000049122	Tyrosine-protein kinase.	Uncharacterized protein.	0.480
ENSGGOP00000030478	G3RRP1_GORGO	ENSGGOP00000030478	ENSGGOP00000018465	Tyrosine-protein kinase.	Uncharacterized protein.	0.801
ENSGGOP00000030478	IL6	ENSGGOP00000030478	ENSGGOP00000018546	Tyrosine-protein kinase.	Interleukin 6.	0.835
ENSGGOP00000030478	IL6R	ENSGGOP00000030478	ENSGGOP00000000824	Tyrosine-protein kinase.	Interleukin 6 receptor.	0.675
ENSGGOP00000030478	IL6ST	ENSGGOP00000030478	ENSGGOP00000003666	Tyrosine-protein kinase.	Fibronectin type-III domain-containing protein.	0.480
ENSGGOP00000030478	JAK1	ENSGGOP00000030478	ENSGGOP00000016069	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.976
ENSGGOP00000030478	MAPK1	ENSGGOP00000030478	ENSGGOP00000040522	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.605
ENSGGOP00000030478	PTPN11	ENSGGOP00000030478	ENSGGOP00000028308	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.881
ENSGGOP00000030478	TYK2	ENSGGOP00000030478	ENSGGOP00000005896	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.972
ENSGGOP00000034163	ENSGGOP00000030478	ENSGGOP00000034163	ENSGGOP00000030478	Uncharacterized protein.	Tyrosine-protein kinase.	0.881
ENSGGOP00000034163	G3R0F2_GORGO	ENSGGOP00000034163	ENSGGOP00000008637	Uncharacterized protein.	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.548
ENSGGOP00000034163	IL6	ENSGGOP00000034163	ENSGGOP00000018546	Uncharacterized protein.	Interleukin 6.	0.564
ENSGGOP00000034163	IL6R	ENSGGOP00000034163	ENSGGOP00000000824	Uncharacterized protein.	Interleukin 6 receptor.	0.575
ENSGGOP00000034163	JAK1	ENSGGOP00000034163	ENSGGOP00000016069	Uncharacterized protein.	Tyrosine-protein kinase.	0.830
ENSGGOP00000034163	MAPK1	ENSGGOP00000034163	ENSGGOP00000040522	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.435
ENSGGOP00000034163	TYK2	ENSGGOP00000034163	ENSGGOP00000005896	Uncharacterized protein.	Tyrosine-protein kinase.	0.565