41 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	YWHAQ	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
	E2F1	E2F transcription factor 1. (437 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	TFDP1	Transcription factor. (411 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	G3RAA2_GORGO	Protein phosphatase 3 catalytic subunit gamma. (483 aa)
	G3RHQ4_GORGO	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	G3RY92_GORGO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (242 aa)
	G3S0Z1_GORGO	Dynein light chain. (91 aa)
	DYNLL2	Uncharacterized protein. (183 aa)
	G3S3D6_GORGO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (242 aa)
	TFDP3	Transcription factor. (405 aa)
	G3S8L5_GORGO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (242 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1090 aa)
	G3SHM7_GORGO	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (210 aa)
	ENSGGOP00000028898	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (195 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1137 aa)
	ENSGGOP00000032522	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (203 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ENSGGOP00000038104	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
	PPP3R1	Uncharacterized protein. (189 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	DYNLL1	Dynein light chain. (89 aa)
	ENSGGOP00000040881	Dynein light chain. (72 aa)
	BMF	Bcl2 modifying factor. (184 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ENSGGOP00000044990	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
	ENSGGOP00000045023	14_3_3 domain-containing protein. (74 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (250 aa)
	ENSGGOP00000046735	Non-specific serine/threonine protein kinase. (524 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TFDP2	Transcription factor. (447 aa)
	ENSGGOP00000050539	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (211 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSGGOP00000033032	ENSGGOP00000007562	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.956
AKT2	BAD	ENSGGOP00000033032	ENSGGOP00000040135	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.950
AKT2	BCL2	ENSGGOP00000033032	ENSGGOP00000000778	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.935
AKT2	ENSGGOP00000046735	ENSGGOP00000033032	ENSGGOP00000046735	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.878
AKT2	MAPK8	ENSGGOP00000033032	ENSGGOP00000049273	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.442
AKT3	AKT2	ENSGGOP00000007562	ENSGGOP00000033032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.956
AKT3	BAD	ENSGGOP00000007562	ENSGGOP00000040135	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.950
AKT3	BCL2	ENSGGOP00000007562	ENSGGOP00000000778	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.931
AKT3	ENSGGOP00000046735	ENSGGOP00000007562	ENSGGOP00000046735	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.531
BAD	AKT2	ENSGGOP00000040135	ENSGGOP00000033032	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.950
BAD	AKT3	ENSGGOP00000040135	ENSGGOP00000007562	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.950
BAD	BCL2	ENSGGOP00000040135	ENSGGOP00000000778	BCL2 associated agonist of cell death.	BCL2 apoptosis regulator.	0.999
BAD	BCL2L11	ENSGGOP00000040135	ENSGGOP00000047932	BCL2 associated agonist of cell death.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.795
BAD	BID	ENSGGOP00000040135	ENSGGOP00000010297	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.680
BAD	ENSGGOP00000028898	ENSGGOP00000040135	ENSGGOP00000028898	BCL2 associated agonist of cell death.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.496
BAD	ENSGGOP00000032522	ENSGGOP00000040135	ENSGGOP00000032522	BCL2 associated agonist of cell death.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.773
BAD	ENSGGOP00000038104	ENSGGOP00000040135	ENSGGOP00000038104	BCL2 associated agonist of cell death.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.752
BAD	ENSGGOP00000044990	ENSGGOP00000040135	ENSGGOP00000044990	BCL2 associated agonist of cell death.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.752
BAD	ENSGGOP00000045023	ENSGGOP00000040135	ENSGGOP00000045023	BCL2 associated agonist of cell death.	14_3_3 domain-containing protein.	0.590
BAD	ENSGGOP00000046735	ENSGGOP00000040135	ENSGGOP00000046735	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase.	0.962