STRINGSTRING
G3QUW7_GORGO G3QUW7_GORGO TRAF2 TRAF2 CD14 CD14 CFLAR CFLAR TNFRSF10B TNFRSF10B TRADD TRADD RIPK1 RIPK1 LY96 LY96 FADD FADD TLR4 TLR4 ENSGGOP00000021036 ENSGGOP00000021036 TICAM2 TICAM2 FASLG FASLG FAS FAS ENSGGOP00000033404 ENSGGOP00000033404 TNFRSF10A TNFRSF10A G3RF33_GORGO G3RF33_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QUW7_GORGOTIR domain-containing adapter molecule 1. (563 aa)
TRAF2TNF receptor-associated factor. (451 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
TRADDDeath domain-containing protein. (251 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
LY96Lymphocyte antigen 96. (160 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
ENSGGOP00000021036annotation not available (839 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
FASFas cell surface death receptor. (340 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
G3RF33_GORGOTumor necrosis factor ligand superfamily member. (281 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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