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| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | G3QFC0_GORGO | NFKB inhibitor interacting Ras like 2. (229 aa) |
| | UBC | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa) |
| | G3QHL6_GORGO | Interleukin 1 receptor associated kinase 2. (538 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | UBA52 | Ubiquitin-like domain-containing protein. (233 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | EEA1 | Early endosome antigen 1. (1411 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | G3QSG6_GORGO | Mitogen-activated protein kinase kinase kinase 20. (780 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (937 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | G3QUW7_GORGO | TIR domain-containing adapter molecule 1. (563 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (902 aa) |
| | TRAF2 | TNF receptor-associated factor. (451 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | SP100 | Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa) |
| | G3QXZ2_GORGO | F-box and WD repeat domain containing 11. (542 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1036 aa) |
| | ELK1 | ETS transcription factor ELK1. (452 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (327 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | G3R428_GORGO | Protein phosphatase 2 scaffold subunit Abeta. (620 aa) |
| | G3R462_GORGO | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | RBSN | Rabenosyn, RAB effector. (784 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | G3REJ1_GORGO | Leucine rich repeat containing 14. (493 aa) |
| | FNBP4 | Formin binding protein 4. (1019 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1347 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa) |
| | G3RGS2_GORGO | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | G3RHM6_GORGO | WRNPLPNID domain-containing protein. (946 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | G3RID2_GORGO | TIR domain-containing protein. (1033 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ALPK1 | Alpha kinase 1. (1244 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | ENSGGOP00000019740 | annotation not available (156 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ENSGGOP00000021036 | annotation not available (839 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1414 aa) |
| | SAA4 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (235 aa) |
| | S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa) |
| | G3SBY7_GORGO | Leucine rich repeat containing 74B. (392 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (474 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (504 aa) |
| | G3SE49_GORGO | NLR family pyrin domain containing 9. (934 aa) |
| | G3SEP4_GORGO | Ubiquitin-like domain-containing protein. (156 aa) |
| | HMGB1 | Uncharacterized protein. (215 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (349 aa) |
| | ENSGGOP00000029090 | Uncharacterized protein. (195 aa) |
| | ENSGGOP00000030202 | Uncharacterized protein. (279 aa) |
| | ENSGGOP00000031261 | Myocyte enhancer factor 2C. (483 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | ENSGGOP00000031801 | CCHC NOA-type domain-containing protein. (346 aa) |
| | ENSGGOP00000032556 | Leucine rich repeat containing 31. (496 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | ENSGGOP00000032619 | cAMP responsive element binding protein 1. (341 aa) |
| | ENSGGOP00000033404 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | PELI2 | Pellino E3 ubiquitin protein ligase family member 2. (394 aa) |
| | CREM | cAMP responsive element modulator. (344 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (184 aa) |
| | ENSGGOP00000034513 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSGGOP00000034747 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | ENSGGOP00000035103 | Protein kinase domain-containing protein. (379 aa) |
| | ENSGGOP00000035952 | TNF receptor-associated factor. (485 aa) |
| | ECSIT | ECSIT signalling integrator. (431 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa) |
| | ENSGGOP00000038520 | Ubiquitin-like domain-containing protein. (187 aa) |
| | MAPKAPK2 | Protein kinase domain-containing protein. (374 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (524 aa) |
| | ENSGGOP00000039123 | CCHC NOA-type domain-containing protein. (371 aa) |
| | ENSGGOP00000040207 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (400 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ENSGGOP00000041058 | annotation not available (54 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | CUL1 | Cullin domain-containing protein; Belongs to the cullin family. (323 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (849 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | ENSGGOP00000044534 | Protein kinase domain-containing protein. (363 aa) |
| | NLRP6 | Uncharacterized protein. (912 aa) |
| | ATF1 | Activating transcription factor 1. (270 aa) |
| | ENSGGOP00000046510 | Uncharacterized protein; Belongs to the SKP1 family. (164 aa) |
| | ENSGGOP00000047060 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa) |
| | ENSGGOP00000047423 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (126 aa) |
| | ENSGGOP00000048677 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (460 aa) |
| | ENSGGOP00000049072 | Protein kinase domain-containing protein. (296 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | APP | Amyloid beta precursor protein. (771 aa) |
| | ENSGGOP00000049938 | Uncharacterized protein. (177 aa) |
| | ENSGGOP00000050319 | Advanced glycosylation end-product specific receptor. (411 aa) |
| | ENSGGOP00000050590 | Uncharacterized protein. (258 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | ENSGGOP00000051849 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (381 aa) |
