81 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3QFC0_GORGO	NFKB inhibitor interacting Ras like 2. (229 aa)
	UBC	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	NFKBIB	NFKB inhibitor beta. (356 aa)
	NLRX1	NLR family member X1. (975 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (608 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	RNF135	Ring finger protein 135. (372 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (270 aa)
	CREBBP	CREB binding protein. (2436 aa)
	S100A12	S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (902 aa)
	TRAF2	TNF receptor-associated factor. (451 aa)
	ITCH	E3 ubiquitin-protein ligase. (903 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	SP100	Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa)
	EP300	E1A binding protein p300. (2416 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	CHUK	IKKbetaNEMObind domain-containing protein. (434 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	NLRC5	NLR family CARD domain containing 5. (1866 aa)
	G3R3U7_GORGO	Mitochondrial antiviral signaling protein. (481 aa)
	G3R462_GORGO	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
	VWC2	Von Willebrand factor C domain containing 2. (325 aa)
	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1035 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	PCBP2	Poly(rC) binding protein 2. (366 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (192 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
	G3RG63_GORGO	ISG15 ubiquitin like modifier. (165 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSGGOP00000050347	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (151 aa)
	ENSGGOP00000050319	Advanced glycosylation end-product specific receptor. (411 aa)
	ENSGGOP00000049938	Uncharacterized protein. (177 aa)
	APP	Amyloid beta precursor protein. (771 aa)
	IFNA13	Interferon alpha 13. (195 aa)
	IRF7	Interferon regulatory factor 7. (516 aa)
	ENSGGOP00000043564	Interferon regulatory factor 3. (452 aa)
	OTUD5	OTU domain-containing protein. (204 aa)
	ENSGGOP00000038520	Ubiquitin-like domain-containing protein. (187 aa)
	ENSGGOP00000038498	Tripartite motif containing 4. (500 aa)
	ENSGGOP00000037555	Uncharacterized protein. (118 aa)
	ENSGGOP00000036074	HATPase_c domain-containing protein. (596 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	ENSGGOP00000035522	Interferon alpha 1. (198 aa)
	ENSGGOP00000033404	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	ENSGGOP00000032596	CCHC NOA-type domain-containing protein. (417 aa)
	TAX1BP1	Tax1 binding protein 1. (779 aa)
	ENSGGOP00000031121	Uncharacterized protein. (361 aa)
	ENSGGOP00000030202	Uncharacterized protein. (279 aa)
	ENSGGOP00000030134	Peptidyl-prolyl cis-trans isomerase. (155 aa)
	ENSGGOP00000029090	Uncharacterized protein. (195 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	HMGB1	Uncharacterized protein. (215 aa)
	G3SEP4_GORGO	Ubiquitin-like domain-containing protein. (156 aa)
	G3SEF7_GORGO	Uncharacterized protein. (463 aa)
	TKFC	Triokinase and FMN cyclase. (576 aa)
	S100B	S_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	G3S4Z2_GORGO	Uncharacterized protein. (119 aa)
	SAA4	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	ENSGGOP00000019740	annotation not available (156 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	IFNB1	Interferon beta 1. (187 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CREBBP	ENSGGOP00000049928	ENSGGOP00000005899	Amyloid beta precursor protein.	CREB binding protein.	0.572
APP	ENSGGOP00000050319	ENSGGOP00000049928	ENSGGOP00000050319	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.734
APP	EP300	ENSGGOP00000049928	ENSGGOP00000008032	Amyloid beta precursor protein.	E1A binding protein p300.	0.763
APP	G3S4Z2_GORGO	ENSGGOP00000049928	ENSGGOP00000023146	Amyloid beta precursor protein.	Uncharacterized protein.	0.420
APP	NFKB1	ENSGGOP00000049928	ENSGGOP00000018764	Amyloid beta precursor protein.	Nuclear factor kappa B subunit 1.	0.713
APP	NFKB2	ENSGGOP00000049928	ENSGGOP00000006827	Amyloid beta precursor protein.	Nuclear factor kappa B subunit 2.	0.461
APP	RELA	ENSGGOP00000049928	ENSGGOP00000027696	Amyloid beta precursor protein.	RELA proto-oncogene, NF-kB subunit.	0.405
APP	S100B	ENSGGOP00000049928	ENSGGOP00000024407	Amyloid beta precursor protein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.478
ATG12	ATG5	ENSGGOP00000016476	ENSGGOP00000016228	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DDX58	ENSGGOP00000016476	ENSGGOP00000024163	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.986
ATG12	DHX58	ENSGGOP00000016476	ENSGGOP00000005347	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.494
ATG12	ENSGGOP00000033404	ENSGGOP00000016476	ENSGGOP00000033404	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.672
ATG12	ENSGGOP00000050347	ENSGGOP00000016476	ENSGGOP00000050347	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.546
ATG12	FADD	ENSGGOP00000016476	ENSGGOP00000020107	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.809
ATG12	G3R3U7_GORGO	ENSGGOP00000016476	ENSGGOP00000009929	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.886
ATG12	HMGB1	ENSGGOP00000016476	ENSGGOP00000027176	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.410
ATG12	IFIH1	ENSGGOP00000016476	ENSGGOP00000015505	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.848
ATG12	NLRX1	ENSGGOP00000016476	ENSGGOP00000003169	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.672
ATG12	RIPK1	ENSGGOP00000016476	ENSGGOP00000012277	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Receptor interacting serine/threonine kinase 1.	0.477
ATG12	UBA7	ENSGGOP00000016476	ENSGGOP00000028165	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.591