STRINGSTRING
PPP2CA PPP2CA FOS FOS NAB2 NAB2 SGK1 SGK1 RALB RALB REST REST EGR3 EGR3 G3QK90_GORGO G3QK90_GORGO RPS6KA1 RPS6KA1 G3QKL3_GORGO G3QKL3_GORGO RALGDS RALGDS MAP2K1 MAP2K1 MAPK13 MAPK13 RPS6KA5 RPS6KA5 ERAS ERAS YWHAB YWHAB ARC ARC MAP2K5 MAP2K5 EGR2 EGR2 G3QRE4_GORGO G3QRE4_GORGO ASCL1 ASCL1 RIT2 RIT2 DUSP4 DUSP4 MAPK7 MAPK7 GRB2 GRB2 PPP4R1 PPP4R1 PPP2R1A PPP2R1A CRK CRK EGR4 EGR4 PPP2R5D PPP2R5D ASCL2 ASCL2 CDK5R2 CDK5R2 PLCG1 PLCG1 MAPK15 MAPK15 CLTC CLTC G3QYD4_GORGO G3QYD4_GORGO TCF12 TCF12 EP300 EP300 ID3 ID3 G3R009_GORGO G3R009_GORGO DNM3 DNM3 ELK1 ELK1 G3R0F2_GORGO G3R0F2_GORGO RPS6KA3 RPS6KA3 PIK3CA PIK3CA PIK3CB PIK3CB G3R428_GORGO G3R428_GORGO SHC4 SHC4 FOSL1 FOSL1 SHC3 SHC3 ADORA2A ADORA2A RHOA RHOA G3RBH6_GORGO G3RBH6_GORGO SHC1 SHC1 DNAL4 DNAL4 NAB1 NAB1 PPP2CB PPP2CB NTRK2 NTRK2 FNBP4 FNBP4 MAPK12 MAPK12 MAPKAPK3 MAPKAPK3 RELCH RELCH IRS2 IRS2 G3RHM6_GORGO G3RHM6_GORGO G3RIH3_GORGO G3RIH3_GORGO ID1 ID1 DNM1 DNM1 TPH1 TPH1 G3RMT0_GORGO G3RMT0_GORGO G3RNM7_GORGO G3RNM7_GORGO SRC SRC CHD4 CHD4 G3RSU6_GORGO G3RSU6_GORGO G3RTG9_GORGO G3RTG9_GORGO STAT3 STAT3 FOSB FOSB G3S176_GORGO G3S176_GORGO MAPK3 MAPK3 RIT1 RIT1 AP2B1 AP2B1 SOS1 SOS1 MAPK11 MAPK11 DNM2 DNM2 G3S843_GORGO G3S843_GORGO LYL1 LYL1 BRAF BRAF VRK3 VRK3 DUSP6 DUSP6 MEF2A MEF2A G3SGM2_GORGO G3SGM2_GORGO DUSP3 DUSP3 MEF2D MEF2D VGF VGF DUSP7 DUSP7 FRS2 FRS2 SH3GL2 SH3GL2 ENSGGOP00000030268 ENSGGOP00000030268 EGR1 EGR1 IRS1 IRS1 ENSGGOP00000031261 ENSGGOP00000031261 ATF2 ATF2 ENSGGOP00000031915 ENSGGOP00000031915 ENSGGOP00000032619 ENSGGOP00000032619 ENSGGOP00000032627 ENSGGOP00000032627 NRAS NRAS ENSGGOP00000033662 ENSGGOP00000033662 CREM CREM NGF NGF RPS6KA2 RPS6KA2 ENSGGOP00000035103 ENSGGOP00000035103 ENSGGOP00000037735 ENSGGOP00000037735 ENSGGOP00000037801 ENSGGOP00000037801 CRKL CRKL MAPKAPK2 MAPKAPK2 HRAS HRAS F3 F3 NTRK1 NTRK1 MAPK1 MAPK1 AP2S1 AP2S1 ENSGGOP00000041959 ENSGGOP00000041959 PPP4R4 PPP4R4 TRIB2 TRIB2 ENSGGOP00000043662 ENSGGOP00000043662 CDK5R1 CDK5R1 ENSGGOP00000044220 ENSGGOP00000044220 CSDE1 CSDE1 JUNB JUNB ATF1 ATF1 ADCYAP1 ADCYAP1 KIDINS220 KIDINS220 RRAD RRAD RALA RALA ENSGGOP00000048050 ENSGGOP00000048050 ENSGGOP00000048177 ENSGGOP00000048177 ENSGGOP00000048306 ENSGGOP00000048306 ENSGGOP00000048385 ENSGGOP00000048385 ENSGGOP00000049072 ENSGGOP00000049072 SHC2 SHC2 PIK3R1 PIK3R1 AP2A2 AP2A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NAB2NGFI-A binding protein 2. (525 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
RALBRAS like proto-oncogene B. (228 aa)
RESTRE1 silencing transcription factor. (1081 aa)
EGR3Early growth response 3. (349 aa)
G3QK90_GORGOUncharacterized protein. (206 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
G3QKL3_GORGOUncharacterized protein. (188 aa)
RALGDSUncharacterized protein. (914 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
ERASES cell expressed Ras. (233 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
EGR2Early growth response 2. (476 aa)
G3QRE4_GORGOTribbles pseudokinase 1. (372 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
RIT2Ras like without CAAX 2. (217 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (937 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
EGR4Early growth response 4. (589 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
CDK5R2Uncharacterized protein. (95 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
G3QYD4_GORGOKRAS proto-oncogene, GTPase. (189 aa)
TCF12Transcription factor 12. (706 aa)
EP300E1A binding protein p300. (2416 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
G3R009_GORGONTPase KAP family P-loop domain containing 1. (610 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
ELK1ETS transcription factor ELK1. (452 aa)
G3R0F2_GORGOMitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
G3R428_GORGOProtein phosphatase 2 scaffold subunit Abeta. (620 aa)
SHC4SHC adaptor protein 4. (630 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SHC3SHC adaptor protein 3. (598 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
RHOAUncharacterized protein. (179 aa)
G3RBH6_GORGOClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (227 aa)
SHC1SHC adaptor protein 1. (584 aa)
DNAL4Dynein light chain. (105 aa)
NAB1NGFI-A binding protein 1. (471 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NTRK2Tyrosine-protein kinase receptor. (767 aa)
FNBP4Formin binding protein 4. (1019 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
IRS2Insulin receptor substrate 2. (1220 aa)
G3RHM6_GORGOWRNPLPNID domain-containing protein. (946 aa)
G3RIH3_GORGOADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
DNM1Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (319 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
G3RMT0_GORGOSH3 domain containing GRB2 like 3, endophilin A3. (317 aa)
G3RNM7_GORGOProtein kinase domain-containing protein. (405 aa)
SRCTyrosine-protein kinase. (542 aa)
CHD4Uncharacterized protein. (1912 aa)
G3RSU6_GORGOUncharacterized protein. (499 aa)
G3RTG9_GORGOAP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (880 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
G3S176_GORGOMADS-box domain-containing protein. (473 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
RIT1Ras like without CAAX 1. (236 aa)
AP2B1AP complex subunit beta. (951 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
G3S843_GORGOBZIP domain-containing protein. (215 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MEF2AMyocyte enhancer factor 2A. (504 aa)
G3SGM2_GORGOAP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
VGFUncharacterized protein. (336 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (349 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
ENSGGOP00000030268Uncharacterized protein. (596 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ENSGGOP00000031261Myocyte enhancer factor 2C. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSGGOP00000031915Uncharacterized protein. (110 aa)
ENSGGOP00000032619cAMP responsive element binding protein 1. (341 aa)
ENSGGOP00000032627Uncharacterized protein. (118 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSGGOP00000033662Dynamin_M domain-containing protein. (120 aa)
CREMcAMP responsive element modulator. (344 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ENSGGOP00000035103Protein kinase domain-containing protein. (379 aa)
ENSGGOP00000037735Uncharacterized protein. (471 aa)
ENSGGOP00000037801Uncharacterized protein. (203 aa)
CRKLUncharacterized protein. (201 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (128 aa)
ENSGGOP00000041959Uncharacterized protein. (413 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (849 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
ENSGGOP00000043662Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ENSGGOP00000044220Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (88 aa)
CSDE1Cold shock domain containing E1. (844 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ATF1Activating transcription factor 1. (270 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
KIDINS220Kinase D interacting substrate 220. (1773 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (300 aa)
RALAUncharacterized protein. (112 aa)
ENSGGOP00000048050SH2 domain-containing protein. (132 aa)
ENSGGOP00000048177B2-adapt-app_C domain-containing protein. (874 aa)
ENSGGOP00000048306Adaptin_N domain-containing protein. (344 aa)
ENSGGOP00000048385Rap guanine nucleotide exchange factor 1. (1095 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
SHC2Uncharacterized protein. (518 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (943 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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