STRINGSTRING
SHC2 SHC2 ENSGGOP00000049760 ENSGGOP00000049760 NEDD9 NEDD9 SZRD1 SZRD1 PIK3R1 PIK3R1 LPXN LPXN VEGFC VEGFC ENSGGOP00000051551 ENSGGOP00000051551 ENSGGOP00000051746 ENSGGOP00000051746 BCAR1 BCAR1 NCKAP1 NCKAP1 CALM3 CALM3 NCF2 NCF2 NRP1 NRP1 HSPB1 HSPB1 VEGFD VEGFD FNDC3B FNDC3B PAK1 PAK1 PRKCD PRKCD TENM1 TENM1 RNF222 RNF222 MAPK13 MAPK13 STX7 STX7 CASS4 CASS4 ERAS ERAS ROCK2 ROCK2 ITPR1 ITPR1 FNDC3A FNDC3A MAPKAP1 MAPKAP1 ARVCF ARVCF CRK CRK FLT4 FLT4 AAMP AAMP WASF1 WASF1 TRIB3 TRIB3 AKT3 AKT3 ITGB3 ITGB3 PLCG1 PLCG1 G3QXY3_GORGO G3QXY3_GORGO G3QYD4_GORGO G3QYD4_GORGO FYN FYN THEM4 THEM4 ACTL7B ACTL7B NCKAP1L NCKAP1L FLT1 FLT1 PIK3CA PIK3CA NRP2 NRP2 ROCK1 ROCK1 PIK3CB PIK3CB JUP JUP SHD SHD MTOR MTOR PRKCB PRKCB TENM3 TENM3 G3R7N7_GORGO G3R7N7_GORGO G3R7P4_GORGO G3R7P4_GORGO AHCYL1 AHCYL1 ELMO3 ELMO3 VEGFB VEGFB VAV1 VAV1 SHF SHF WASF3 WASF3 G3RAC9_GORGO G3RAC9_GORGO KDR KDR RHOA RHOA PRKCZ PRKCZ SH2D2A SH2D2A ACTG1 ACTG1 ELMO2 ELMO2 SHB SHB G3RE39_GORGO G3RE39_GORGO G3REB8_GORGO G3REB8_GORGO MAPK12 MAPK12 ACTL8 ACTL8 PGF PGF MAPKAPK3 MAPKAPK3 DOCK1 DOCK1 ACTRT1 ACTRT1 PTK2B PTK2B PRKCA PRKCA ABI2 ABI2 NOS3 NOS3 SPHK1 SPHK1 ELMO1 ELMO1 EFS EFS NCF4 NCF4 WASF2 WASF2 CTNND1 CTNND1 G3RR23_GORGO G3RR23_GORGO SRC SRC G3RRQ8_GORGO G3RRQ8_GORGO G3RTM5_GORGO G3RTM5_GORGO G3RXW1_GORGO G3RXW1_GORGO BRK1 BRK1 PTK2 PTK2 CYFIP1 CYFIP1 CAV1 CAV1 CTNNA1 CTNNA1 MAPK11 MAPK11 G3S4Z2_GORGO G3S4Z2_GORGO RICTOR RICTOR ACTL7A ACTL7A PDPK1 PDPK1 ITPR3 ITPR3 CYFIP2 CYFIP2 PRKACB PRKACB NCK1 NCK1 MLST8 MLST8 VAV2 VAV2 G3SEV0_GORGO G3SEV0_GORGO CDH5 CDH5 SHE SHE HSH2D HSH2D NCK2 NCK2 ENSGGOP00000030268 ENSGGOP00000030268 ENSGGOP00000030465 ENSGGOP00000030465 BAIAP2 BAIAP2 TENM2 TENM2 ENSGGOP00000031235 ENSGGOP00000031235 ENSGGOP00000032040 ENSGGOP00000032040 TGFB1I1 TGFB1I1 PAK2 PAK2 NRAS NRAS AKT2 AKT2 RAC1 RAC1 ENSGGOP00000038462 ENSGGOP00000038462 MAPKAPK2 MAPKAPK2 NCF1 NCF1 HRAS HRAS ENSGGOP00000039174 ENSGGOP00000039174 ITPR2 ITPR2 ENSGGOP00000039941 ENSGGOP00000039941 ENSGGOP00000040139 ENSGGOP00000040139 ENSGGOP00000040681 ENSGGOP00000040681 RASA1 RASA1 ITGAV ITGAV CDC42 CDC42 ENSGGOP00000043690 ENSGGOP00000043690 ENSGGOP00000044113 ENSGGOP00000044113 CSDE1 CSDE1 ENSGGOP00000045477 ENSGGOP00000045477 ENSGGOP00000045879 ENSGGOP00000045879 ENSGGOP00000045882 ENSGGOP00000045882 ENSGGOP00000046735 ENSGGOP00000046735 STX12 STX12 ENSGGOP00000047465 ENSGGOP00000047465 VAV3 VAV3 CTNNB1 CTNNB1 ENSGGOP00000049072 ENSGGOP00000049072
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC2Uncharacterized protein. (518 aa)
ENSGGOP00000049760SUZ-C domain-containing protein. (122 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
SZRD1SUZ domain-containing protein. (134 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (391 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (230 aa)
ENSGGOP00000051551Proline rich 5. (372 aa)
ENSGGOP00000051746Uncharacterized protein. (154 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
NCKAP1NCK associated protein 1. (1134 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FNDC3BFibronectin type III domain containing 3B. (1188 aa)
PAK1Non-specific serine/threonine protein kinase. (554 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
RNF222Ring finger protein 222. (220 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
ERASES cell expressed Ras. (233 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
ARVCFARVCF delta catenin family member. (962 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1319 aa)
AAMPAngio associated migratory cell protein. (434 aa)
WASF1WASP family member 1. (559 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (837 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
G3QXY3_GORGOCytochrome b-245 beta chain. (570 aa)
G3QYD4_GORGOKRAS proto-oncogene, GTPase. (189 aa)
FYNTyrosine-protein kinase. (537 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
JUPJunction plakoglobin. (745 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TENM3Teneurin transmembrane protein 3. (2699 aa)
G3R7N7_GORGOAbl interactor 1. (508 aa)
G3R7P4_GORGOTeneurin transmembrane protein 4. (2690 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
ELMO3Engulfment and cell motility 3. (773 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
VAV1Vav guanine nucleotide exchange factor 1. (788 aa)
SHFSrc homology 2 domain containing F. (423 aa)
WASF3WASP family member 3. (502 aa)
G3RAC9_GORGOVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RHOAUncharacterized protein. (179 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
SH2D2ASH2 domain containing 2A. (399 aa)
ACTG1Actin gamma 1. (375 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
SHBSH2 domain containing adaptor protein B. (411 aa)
G3RE39_GORGOActin related protein T2; Belongs to the actin family. (377 aa)
G3REB8_GORGOActin like 9; Belongs to the actin family. (416 aa)
MAPK12Mitogen-activated protein kinase. (312 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (328 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ABI2Abl interactor 2. (535 aa)
NOS3Nitric oxide synthase 3. (997 aa)
SPHK1Sphingosine kinase 1. (472 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
NCF4Uncharacterized protein. (339 aa)
WASF2WASP family member 2. (498 aa)
CTNND1Catenin delta 1. (968 aa)
G3RR23_GORGOUncharacterized protein. (210 aa)
SRCTyrosine-protein kinase. (542 aa)
G3RRQ8_GORGOAXL receptor tyrosine kinase. (843 aa)
G3RTM5_GORGOUncharacterized protein. (394 aa)
G3RXW1_GORGOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
CTNNA1Catenin alpha 1. (906 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
PDPK1Protein kinase domain-containing protein. (347 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NCK1Cytoplasmic protein. (377 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
G3SEV0_GORGOUncharacterized protein; Belongs to the calmodulin family. (152 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
SHESrc homology 2 domain containing E. (495 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSGGOP00000030268Uncharacterized protein. (596 aa)
ENSGGOP00000030465Uncharacterized protein; Belongs to the actin family. (314 aa)
BAIAP2BAI1 associated protein 2. (548 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
ENSGGOP00000031235Uncharacterized protein; Belongs to the calmodulin family. (129 aa)
ENSGGOP00000032040Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAC1Rac family small GTPase 1. (211 aa)
ENSGGOP00000038462Uncharacterized protein. (383 aa)
MAPKAPK2Protein kinase domain-containing protein. (374 aa)
NCF1Uncharacterized protein. (367 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSGGOP00000039174Uncharacterized protein. (417 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
ENSGGOP00000039941Uncharacterized protein. (205 aa)
ENSGGOP00000040139Uncharacterized protein. (86 aa)
ENSGGOP00000040681Uncharacterized protein; Belongs to the calmodulin family. (70 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1002 aa)
CDC42Cell division cycle 42. (191 aa)
ENSGGOP00000043690Uncharacterized protein. (113 aa)
ENSGGOP00000044113Uncharacterized protein. (1081 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSGGOP00000045477Non-specific serine/threonine protein kinase. (530 aa)
ENSGGOP00000045879Uncharacterized protein; Belongs to the actin family. (361 aa)
ENSGGOP00000045882Actin beta. (378 aa)
ENSGGOP00000046735Non-specific serine/threonine protein kinase. (524 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
ENSGGOP00000047465P21 (RAC1) activated kinase 3. (580 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSGGOP00000049072Protein kinase domain-containing protein. (296 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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