STRINGSTRING
G3QRS6_GORGO G3QRS6_GORGO MCF2L2 MCF2L2 TRAF6 TRAF6 ARHGEF2 ARHGEF2 UBC UBC AKAP13 AKAP13 SESTD1 SESTD1 ARHGEF9 ARHGEF9 MAPK10 MAPK10 ENSGGOP00000050590 ENSGGOP00000050590 ARHGEF10 ARHGEF10 MAPK8 MAPK8 SOS2 SOS2 ARHGEF12 ARHGEF12 NCSTN NCSTN PLEKHG2 PLEKHG2 VAV3 VAV3 BCL2L11 BCL2L11 ENSGGOP00000047272 ENSGGOP00000047272 APH1B APH1B ARHGEF3 ARHGEF3 ARHGEF10L ARHGEF10L ARHGEF33 ARHGEF33 YWHAE YWHAE RASGRF2 RASGRF2 BAD BAD MCF2 MCF2 ENSGGOP00000038520 ENSGGOP00000038520 ENSGGOP00000037890 ENSGGOP00000037890 ARHGEF4 ARHGEF4 ARHGEF39 ARHGEF39 PREX1 PREX1 ENSGGOP00000035952 ENSGGOP00000035952 ITSN1 ITSN1 RAC1 RAC1 NGF NGF ENSGGOP00000032522 ENSGGOP00000032522 BEX3 BEX3 ARHGEF26 ARHGEF26 ARHGEF7 ARHGEF7 ENSGGOP00000028898 ENSGGOP00000028898 ARHGEF16 ARHGEF16 G3SHM7_GORGO G3SHM7_GORGO ARHGEF19 ARHGEF19 PLEKHG5 PLEKHG5 G3SEP4_GORGO G3SEP4_GORGO VAV2 VAV2 ARHGEF5 ARHGEF5 G3SDL1_GORGO G3SDL1_GORGO ARHGEF11 ARHGEF11 AATF AATF G3SC71_GORGO G3SC71_GORGO G3S4X5_GORGO G3S4X5_GORGO SOS1 SOS1 NET1 NET1 ECT2 ECT2 CASP3 CASP3 G3RYA7_GORGO G3RYA7_GORGO SQSTM1 SQSTM1 G3RVX1_GORGO G3RVX1_GORGO ENSGGOP00000019740 ENSGGOP00000019740 APH1A APH1A ABR ABR PSENEN PSENEN TGM6 TGM6 ARHGEF1 ARHGEF1 TIAM1 TIAM1 G3RDU1_GORGO G3RDU1_GORGO ARHGEF6 ARHGEF6 G3RCS6_GORGO G3RCS6_GORGO ECT2L ECT2L VAV1 VAV1 G3R907_GORGO G3R907_GORGO ARHGEF15 ARHGEF15 ARHGEF38 ARHGEF38 ARHGEF17 ARHGEF17 GNA13 GNA13 FGD3 FGD3 NGFR NGFR FGD1 FGD1 NGEF NGEF RPS27A RPS27A ARHGEF40 ARHGEF40 KALRN KALRN ARHGEF37 ARHGEF37 PSEN1 PSEN1 PSEN2 PSEN2 CASP2 CASP2 ITGB3BP ITGB3BP G3QPY2_GORGO G3QPY2_GORGO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QRS6_GORGOFYVE, RhoGEF and PH domain containing 2. (655 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
AKAP13A-kinase anchoring protein 13. (2817 aa)
SESTD1SEC14 and spectrin domain containing 1. (696 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (587 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
ENSGGOP00000050590Uncharacterized protein. (258 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1369 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1504 aa)
NCSTNNicastrin. (721 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1386 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSGGOP00000047272FYVE, RhoGEF and PH domain containing 4. (856 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1277 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (870 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MCF2MCF.2 cell line derived transforming sequence. (1001 aa)
ENSGGOP00000038520Ubiquitin-like domain-containing protein. (187 aa)
ENSGGOP00000037890Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8820 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (690 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1658 aa)
ENSGGOP00000035952TNF receptor-associated factor. (485 aa)
ITSN1Intersectin 1. (1721 aa)
RAC1Rac family small GTPase 1. (211 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
ENSGGOP0000003252214_3_3 domain-containing protein; Belongs to the 14-3-3 family. (203 aa)
BEX3Brain expressed X-linked 3. (121 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (871 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (803 aa)
ENSGGOP0000002889814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (195 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (709 aa)
G3SHM7_GORGO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (210 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (796 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1063 aa)
G3SEP4_GORGOUbiquitin-like domain-containing protein. (156 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
ARHGEF5Rho guanine nucleotide exchange factor 35. (479 aa)
G3SDL1_GORGOUncharacterized protein. (434 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1562 aa)
AATFApoptosis antagonizing transcription factor. (560 aa)
G3SC71_GORGOUncharacterized protein. (420 aa)
G3S4X5_GORGOMAGE family member D1. (834 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NET1Neuroepithelial cell transforming 1. (599 aa)
ECT2Epithelial cell transforming 2. (914 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
G3RYA7_GORGOUncharacterized protein. (382 aa)
SQSTM1Sequestosome 1. (440 aa)
G3RVX1_GORGOUncharacterized protein. (547 aa)
ENSGGOP00000019740annotation not available (156 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
TGM6Transglutaminase 6. (703 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (948 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
G3RDU1_GORGOMCF.2 cell line derived transforming sequence like. (1137 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
G3RCS6_GORGOTrio Rho guanine nucleotide exchange factor. (2867 aa)
ECT2LEpithelial cell transforming 2 like. (904 aa)
VAV1Vav guanine nucleotide exchange factor 1. (788 aa)
G3R907_GORGOT cell lymphoma invasion and metastasis 2. (1725 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (841 aa)
ARHGEF38DH domain-containing protein. (219 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2064 aa)
GNA13G protein subunit alpha 13. (377 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (725 aa)
NGFRNerve growth factor receptor. (427 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (961 aa)
NGEFNeuronal guanine nucleotide exchange factor. (709 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1517 aa)
KALRNUncharacterized protein. (2986 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (675 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (215 aa)
G3QPY2_GORGOUncharacterized protein. (1173 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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