15 items (Gorilla gorilla) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	G3R515_GORGO	Protein kinase C iota. (557 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	UBC	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
	ENSGGOP00000038520	Ubiquitin-like domain-containing protein. (187 aa)
	ENSGGOP00000035952	TNF receptor-associated factor. (485 aa)
	NGF	Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
	G3SEP4_GORGO	Ubiquitin-like domain-containing protein. (156 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	ENSGGOP00000019740	annotation not available (156 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000019740	ENSGGOP00000035952	ENSGGOP00000019740	ENSGGOP00000035952	annotation not available	TNF receptor-associated factor.	0.665
ENSGGOP00000019740	ENSGGOP00000038520	ENSGGOP00000019740	ENSGGOP00000038520	annotation not available	Ubiquitin-like domain-containing protein.	0.544
ENSGGOP00000019740	G3SEP4_GORGO	ENSGGOP00000019740	ENSGGOP00000026578	annotation not available	Ubiquitin-like domain-containing protein.	0.543
ENSGGOP00000019740	IKBKB	ENSGGOP00000019740	ENSGGOP00000006628	annotation not available	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.426
ENSGGOP00000019740	IRAK1	ENSGGOP00000019740	ENSGGOP00000018313	annotation not available	Interleukin 1 receptor associated kinase 1.	0.403
ENSGGOP00000019740	RPS27A	ENSGGOP00000019740	ENSGGOP00000007509	annotation not available	Ubiquitin-like domain-containing protein.	0.543
ENSGGOP00000019740	SQSTM1	ENSGGOP00000019740	ENSGGOP00000020182	annotation not available	Sequestosome 1.	0.632
ENSGGOP00000019740	TRAF6	ENSGGOP00000019740	ENSGGOP00000005734	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.667
ENSGGOP00000019740	UBC	ENSGGOP00000019740	ENSGGOP00000001286	annotation not available	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.905
ENSGGOP00000035952	ENSGGOP00000019740	ENSGGOP00000035952	ENSGGOP00000019740	TNF receptor-associated factor.	annotation not available	0.665
ENSGGOP00000035952	ENSGGOP00000038520	ENSGGOP00000035952	ENSGGOP00000038520	TNF receptor-associated factor.	Ubiquitin-like domain-containing protein.	0.665
ENSGGOP00000035952	G3R515_GORGO	ENSGGOP00000035952	ENSGGOP00000010381	TNF receptor-associated factor.	Protein kinase C iota.	0.526
ENSGGOP00000035952	G3SEP4_GORGO	ENSGGOP00000035952	ENSGGOP00000026578	TNF receptor-associated factor.	Ubiquitin-like domain-containing protein.	0.665
ENSGGOP00000035952	IKBKB	ENSGGOP00000035952	ENSGGOP00000006628	TNF receptor-associated factor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.737
ENSGGOP00000035952	IRAK1	ENSGGOP00000035952	ENSGGOP00000018313	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 1.	0.909
ENSGGOP00000035952	MYD88	ENSGGOP00000035952	ENSGGOP00000003761	TNF receptor-associated factor.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.844
ENSGGOP00000035952	NGFR	ENSGGOP00000035952	ENSGGOP00000008241	TNF receptor-associated factor.	Nerve growth factor receptor.	0.720
ENSGGOP00000035952	RIPK2	ENSGGOP00000035952	ENSGGOP00000010569	TNF receptor-associated factor.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.681
ENSGGOP00000035952	RPS27A	ENSGGOP00000035952	ENSGGOP00000007509	TNF receptor-associated factor.	Ubiquitin-like domain-containing protein.	0.665
ENSGGOP00000035952	SQSTM1	ENSGGOP00000035952	ENSGGOP00000020182	TNF receptor-associated factor.	Sequestosome 1.	0.901