STRINGSTRING
G3QER9_GORGO G3QER9_GORGO UBC UBC CARD16 CARD16 FLOT1 FLOT1 CHMP7 CHMP7 CARD18 CARD18 IL1A IL1A UBA52 UBA52 RIPK3 RIPK3 GSDME GSDME BIRC3 BIRC3 IL1B IL1B G3QV30_GORGO G3QV30_GORGO TRAF2 TRAF2 ITCH ITCH BIRC8 BIRC8 RPS27A RPS27A CHMP4B CHMP4B SP100 SP100 BIRC2 BIRC2 BIRC7 BIRC7 XIAP XIAP BAX BAX CFLAR CFLAR TNFRSF10B TNFRSF10B TRADD TRADD NPVF NPVF G3R8R1_GORGO G3R8R1_GORGO RIPK1 RIPK1 G3RB29_GORGO G3RB29_GORGO PELI1 PELI1 IRF1 IRF1 OGT OGT G3RI71_GORGO G3RI71_GORGO CASP5 CASP5 IL18 IL18 IRF2 IRF2 CHMP4C CHMP4C G3RLK9_GORGO G3RLK9_GORGO CHMP2B CHMP2B G3RQE7_GORGO G3RQE7_GORGO BAK1 BAK1 ENSGGOP00000019740 ENSGGOP00000019740 FADD FADD CHMP4B-2 CHMP4B-2 CASP3 CASP3 CDC37 CDC37 G3S4Z2_GORGO G3S4Z2_GORGO G3S774_GORGO G3S774_GORGO CHMP2A CHMP2A G3S8N2_GORGO G3S8N2_GORGO FASLG FASLG G3SAG0_GORGO G3SAG0_GORGO G3SDM2_GORGO G3SDM2_GORGO G3SEP4_GORGO G3SEP4_GORGO FAS FAS HMGB1 HMGB1 CYCS CYCS ENSGGOP00000029090 ENSGGOP00000029090 ENSGGOP00000030121 ENSGGOP00000030121 ENSGGOP00000030302 ENSGGOP00000030302 MDP1 MDP1 ENSGGOP00000031130 ENSGGOP00000031130 ENSGGOP00000031996 ENSGGOP00000031996 ENSGGOP00000032091 ENSGGOP00000032091 SDCBP SDCBP ENSGGOP00000032650 ENSGGOP00000032650 ENSGGOP00000033404 ENSGGOP00000033404 GSDMB GSDMB MLKL MLKL ENSGGOP00000034513 ENSGGOP00000034513 ENSGGOP00000034757 ENSGGOP00000034757 ENSGGOP00000035213 ENSGGOP00000035213 ENSGGOP00000035808 ENSGGOP00000035808 PRKN PRKN ENSGGOP00000038520 ENSGGOP00000038520 CHMP6 CHMP6 TP63 TP63 UBE2L5 UBE2L5 NAIP NAIP ENSGGOP00000045267 ENSGGOP00000045267 ENSGGOP00000046758 ENSGGOP00000046758 TNFRSF10A TNFRSF10A G3RF33_GORGO G3RF33_GORGO ENSGGOP00000049412 ENSGGOP00000049412 ENSGGOP00000049938 ENSGGOP00000049938 ENSGGOP00000050590 ENSGGOP00000050590 ENSGGOP00000051279 ENSGGOP00000051279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3QER9_GORGOElastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
CARD16Caspase recruitment domain family member 16. (197 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
CARD18Caspase recruitment domain family member 18. (90 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
UBA52Ubiquitin-like domain-containing protein. (233 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
GSDMEGasdermin E. (496 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
G3QV30_GORGOGasdermin D. (532 aa)
TRAF2TNF receptor-associated factor. (451 aa)
ITCHE3 ubiquitin-protein ligase. (903 aa)
BIRC8Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
SP100Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] (209 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
XIAPUncharacterized protein. (371 aa)
BAXBCL2 associated X, apoptosis regulator. (217 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
TNFRSF10BTNF receptor superfamily member 10b. (440 aa)
TRADDDeath domain-containing protein. (251 aa)
NPVFNeuropeptide VF precursor. (196 aa)
G3R8R1_GORGOCaspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (341 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
G3RB29_GORGOGranzyme B; Belongs to the peptidase S1 family. (247 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IRF1Interferon regulatory factor. (325 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
G3RI71_GORGONACHT domain-containing protein. (1127 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (447 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IRF2Interferon regulatory factor. (349 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
G3RLK9_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CHMP2BCharged multivesicular body protein 2B. (228 aa)
G3RQE7_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSGGOP00000019740annotation not available (156 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CHMP4B-2Uncharacterized protein. (201 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CDC37Cell division cycle 37. (378 aa)
G3S4Z2_GORGOUncharacterized protein. (119 aa)
G3S774_GORGOProgrammed cell death 6 interacting protein. (772 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
G3S8N2_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (91 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
G3SAG0_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
G3SDM2_GORGOCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
G3SEP4_GORGOUbiquitin-like domain-containing protein. (156 aa)
FASFas cell surface death receptor. (340 aa)
HMGB1Uncharacterized protein. (215 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
ENSGGOP00000029090Uncharacterized protein. (195 aa)
ENSGGOP00000030121Uncharacterized protein. (354 aa)
ENSGGOP00000030302PDZ domain-containing protein. (258 aa)
MDP1Magnesium dependent phosphatase 1. (164 aa)
ENSGGOP00000031130Uncharacterized protein. (189 aa)
ENSGGOP00000031996Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (91 aa)
ENSGGOP00000032091Caspase 4; Belongs to the peptidase C14A family. (377 aa)
SDCBPSyndecan binding protein. (318 aa)
ENSGGOP00000032650STIP1 homology and U-box containing protein 1. (303 aa)
ENSGGOP00000033404Caspase 8; Belongs to the peptidase C14A family. (496 aa)
GSDMBGasdermin B. (416 aa)
MLKLUncharacterized protein. (178 aa)
ENSGGOP00000034513Ubiquitin-like domain-containing protein. (156 aa)
ENSGGOP00000034757Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (493 aa)
ENSGGOP00000035213TPR_REGION domain-containing protein. (1641 aa)
ENSGGOP00000035808Uncharacterized protein. (272 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ENSGGOP00000038520Ubiquitin-like domain-containing protein. (187 aa)
CHMP6Uncharacterized protein. (224 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
NAIPUncharacterized protein. (198 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
TNFRSF10ATNF receptor superfamily member 10a. (468 aa)
G3RF33_GORGOTumor necrosis factor ligand superfamily member. (281 aa)
ENSGGOP00000049412Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (117 aa)
ENSGGOP00000049938Uncharacterized protein. (177 aa)
ENSGGOP00000050590Uncharacterized protein. (258 aa)
ENSGGOP00000051279UBIQUITIN_CONJUGAT_2 domain-containing protein. (130 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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