Your Input: | |
| | DCLRE1C | DNA cross-link repair 1C. (692 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | RNF168 | Ring finger protein 168. (470 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (585 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | G3RED9_GORGO | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | G3REI5_GORGO | RecQ like helicase 4. (1210 aa) |
| | RNF169 | Ring finger protein 169. (705 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2655 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (729 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1539 aa) |
| | TIMELESS | Timeless circadian regulator. (1179 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1834 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | G3RLZ7_GORGO | Ubiquitin-like domain-containing protein. (157 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) |
| | G3RNX2_GORGO | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4699 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (438 aa) |
| | KDM4B | Lysine demethylase 4B. (1130 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1301 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | G3RU19_GORGO | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | G3RUZ3_GORGO | Uncharacterized protein. (414 aa) |
| | ENSGGOP00000019740 | annotation not available (156 aa) |
| | G3RVL7_GORGO | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | G3RWT4_GORGO | Rad60-SLD domain-containing protein. (62 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | H4C14 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | G3RYW0_GORGO | Importin subunit alpha; Functions in nuclear protein import. (510 aa) |
| | KDM4A | Uncharacterized protein. (1064 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | H4-16 | H4 histone 16. (103 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | G3S2U1_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (710 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (127 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa) |
| | ENSGGOP00000024364 | annotation not available (103 aa) |
| | WRN | WRN RecQ like helicase. (1435 aa) |
| | PPP5D1 | PPP5 domain-containing protein. (119 aa) |
| | PAXIP1 | PAX interacting protein 1. (981 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | G3SDT0_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G3SEH8_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G3SEP4_GORGO | Ubiquitin-like domain-containing protein. (156 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | FEN1-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (308 aa) |
| | G3SG93_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3416 aa) |
| | G3SIR7_GORGO | Ku domain-containing protein. (334 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | G3SK93_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | ENSGGOP00000028787 | MPN domain-containing protein. (307 aa) |
| | ENSGGOP00000028825 | BRCT domain-containing protein. (83 aa) |
| | BAZ1A | PHD-type domain-containing protein. (593 aa) |
| | POLH | UmuC domain-containing protein. (415 aa) |
| | ENSGGOP00000040820 | annotation not available (103 aa) |
| | ENSGGOP00000040711 | ATR interacting protein. (799 aa) |
| | UBXN1 | UBX domain protein 1. (310 aa) |
| | ENSGGOP00000040343 | annotation not available (103 aa) |
| | ENSGGOP00000040293 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD51C | Uncharacterized protein. (52 aa) |
| | G3RXM3_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | ENSGGOP00000038538 | annotation not available (103 aa) |
| | ENSGGOP00000038520 | Ubiquitin-like domain-containing protein. (187 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | ENSGGOP00000037033 | Uncharacterized protein. (66 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) |
| | RBBP8 | CtIP_N domain-containing protein. (896 aa) |
| | ENSGGOP00000036560 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (284 aa) |
| | ENSGGOP00000036466 | Checkpoint kinase 2. (529 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (570 aa) |
| | ENSGGOP00000035767 | Reverse transcriptase domain-containing protein. (252 aa) |
| | ENSGGOP00000035698 | Uncharacterized protein. (301 aa) |
| | ENSGGOP00000035646 | Reverse transcriptase domain-containing protein. (336 aa) |
| | ENSGGOP00000035447 | annotation not available (86 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1112 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (608 aa) |
| | ENSGGOP00000034653 | annotation not available (103 aa) |
| | ENSGGOP00000034513 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSGGOP00000034396 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (592 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSGGOP00000034298 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSGGOP00000034183 | IBB domain-containing protein. (92 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (317 aa) |
| | ENSGGOP00000033329 | Histone domain-containing protein; Belongs to the histone H2B family. (129 aa) |
| | ENSGGOP00000033237 | Uncharacterized protein. (201 aa) |
| | ENSGGOP00000032687 | Histone domain-containing protein. (114 aa) |
| | ENSGGOP00000032004 | annotation not available (103 aa) |
| | ENSGGOP00000031825 | Rad60-SLD domain-containing protein. (86 aa) |
| | ENSGGOP00000031682 | Uncharacterized protein. (404 aa) |
| | ENSGGOP00000031578 | Rad60-SLD domain-containing protein. (84 aa) |
| | ENSGGOP00000031466 | annotation not available (103 aa) |
| | ENSGGOP00000031367 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (95 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (633 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | ENSGGOP00000030990 | Importin subunit alpha; Functions in nuclear protein import. (453 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa) |
| | ENSGGOP00000030108 | Ku domain-containing protein. (592 aa) |
| | ENSGGOP00000029537 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSGGOP00000029300 | Rad60-SLD domain-containing protein. (72 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ENSGGOP00000049118 | Uncharacterized protein. (243 aa) |
| | ENSGGOP00000049227 | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ENSGGOP00000049777 | Rad60-SLD domain-containing protein. (59 aa) |
| | ENSGGOP00000049801 | Uncharacterized protein. (254 aa) |
| | ENSGGOP00000049879 | annotation not available (103 aa) |
| | ENSGGOP00000050208 | annotation not available (126 aa) |
| | ENSGGOP00000050356 | Replication timing regulatory factor 1. (2281 aa) |
| | ENSGGOP00000050590 | Uncharacterized protein. (258 aa) |
| | TDRD3 | Tudor domain containing 3. (730 aa) |
| | ENSGGOP00000050973 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | ENSGGOP00000051553 | annotation not available (126 aa) |
| | ENSGGOP00000051962 | SAP domain-containing protein. (226 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (507 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (720 aa) |
| | H2BC12 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSGGOP00000046562 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (261 aa) |
| | ENSGGOP00000047060 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (283 aa) |
| | ENSGGOP00000047959 | Importin subunit alpha; Functions in nuclear protein import. (445 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (463 aa) |
| | RAD51B | Uncharacterized protein. (118 aa) |
| | ENSGGOP00000048106 | Rad60-SLD domain-containing protein. (84 aa) |
| | ENSGGOP00000048172 | Uncharacterized protein. (482 aa) |
| | ENSGGOP00000048419 | Histone H2B; Belongs to the histone H2B family. (167 aa) |
| | ENSGGOP00000048791 | Uncharacterized protein. (112 aa) |
| | ENSGGOP00000046210 | annotation not available (52 aa) |
| | POLK | DNA polymerase kappa. (897 aa) |
| | ENSGGOP00000045869 | Rad60-SLD domain-containing protein. (95 aa) |
| | ENSGGOP00000045624 | IBB domain-containing protein. (78 aa) |
| | SUMO2 | Ubiquitin-like domain-containing protein. (145 aa) |
| | ENSGGOP00000045253 | annotation not available (103 aa) |
| | ENSGGOP00000045067 | Tudor domain containing 3. (116 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ENSGGOP00000044371 | Reverse transcriptase domain-containing protein. (269 aa) |
| | ENSGGOP00000044043 | Uncharacterized protein. (100 aa) |
| | ENSGGOP00000044032 | annotation not available (103 aa) |
| | POLQ | Uncharacterized protein. (127 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | ENSGGOP00000043105 | RING-type domain-containing protein. (117 aa) |
| | ENSGGOP00000042938 | Checkpoint protein; Belongs to the HUS1 family. (273 aa) |
| | RFC2 | Replication factor C subunit 2. (354 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | ENSGGOP00000042130 | Uncharacterized protein. (112 aa) |
| | ENSGGOP00000042059 | Ubiquitin-like domain-containing protein. (146 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | ENSGGOP00000041542 | annotation not available (103 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) |
| | G3QD86_GORGO | Uncharacterized protein. (198 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (2089 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | UBC | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RFC5 | Replication factor C subunit 5. (354 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1972 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | G3QPE8_GORGO | DNA polymerase mu. (508 aa) |
| | UBA52 | Ubiquitin-like domain-containing protein. (233 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | G3QR56_GORGO | DNA repair protein XRCC4. (336 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | POLD1 | DNA polymerase. (957 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | CLSPN | Claspin. (1335 aa) |
| | G3QTD2_GORGO | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3503 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (375 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (418 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (759 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (912 aa) |
| | G3QXG0_GORGO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | BLM | BLM RecQ like helicase. (1415 aa) |
| | ENSGGOP00000046289 | RAD51_interact domain-containing protein. (288 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | G3QY09_GORGO | Protein inhibitor of activated STAT 4. (510 aa) |
| | G3QYE9_GORGO | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (417 aa) |
| | G3QZQ7_GORGO | H2B histone family member W, testis specific; Belongs to the histone H2B family. (174 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | G3R0N2_GORGO | Uncharacterized protein. (849 aa) |
| | G3R2C0_GORGO | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (294 aa) |
| | G3R3B3_GORGO | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | DNA2 | Uncharacterized protein. (687 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (610 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (410 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | G3R7G1_GORGO | DNA polymerase theta. (2506 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (538 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (354 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | G3RAR0_GORGO | Uncharacterized protein. (714 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
