STRINGSTRING
LRCH2 LRCH2 NLRC4 NLRC4 CASP2 CASP2 ATM ATM CASP10 CASP10 G3RHQ4_GORGO G3RHQ4_GORGO CRADD CRADD CASP6 CASP6 PIDD1 PIDD1 LRCH4 LRCH4 APAF1 APAF1 LRCH3 LRCH3 TP63 TP63 ENSGGOP00000045267 ENSGGOP00000045267 ENSGGOP00000046758 ENSGGOP00000046758 ENSGGOP00000047192 ENSGGOP00000047192
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRCH2Leucine rich repeats and calponin homology domain containing 2. (765 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (523 aa)
G3RHQ4_GORGOTumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
LRCH4Leucine rich repeats and calponin homology domain containing 4. (683 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
LRCH3Leucine rich repeats and calponin homology domain containing 3. (718 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSGGOP00000045267Uncharacterized protein; Belongs to the peptidase C14A family. (342 aa)
ENSGGOP00000046758Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ENSGGOP00000047192Leucine rich repeats and calponin homology domain containing 1. (618 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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