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| | DNA2 | Uncharacterized protein. (687 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3023 aa) |
| | G3R3B3_GORGO | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) |
| | TAF13 | TATA-box binding protein associated factor 13. (124 aa) |
| | UBA52 | Ubiquitin-like domain-containing protein. (233 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (241 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (862 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa) |
| | G3REI5_GORGO | RecQ like helicase 4. (1210 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (773 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa) |
| | ENSGGOP00000050973 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (334 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2655 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (461 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | G3QND7_GORGO | Uncharacterized protein. (264 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (585 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | CHEK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | G3RAW2_GORGO | Polo like kinase 5. (319 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (714 aa) |
| | RFC5 | Replication factor C subunit 5. (354 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (251 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | TAF4 | TAFH domain-containing protein. (635 aa) |
| | TP53RK | TP53 regulating kinase. (253 aa) |
| | UBC | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa) |
| | G3QXM0_GORGO | NOC2 like nucleolar associated transcriptional repressor. (745 aa) |
| | BLM | BLM RecQ like helicase. (1415 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1199 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (278 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (403 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (270 aa) |
| | G3QSE4_GORGO | TATA-box binding protein associated factor 15. (604 aa) |
| | TAF5 | Uncharacterized protein. (610 aa) |
| | TBP | TATA-box binding protein. (332 aa) |
| | TDRD3 | Tudor domain containing 3. (730 aa) |
| | ENSGGOP00000050698 | Uncharacterized protein. (233 aa) |
| | ENSGGOP00000050590 | Uncharacterized protein. (258 aa) |
| | ENSGGOP00000049072 | Protein kinase domain-containing protein. (296 aa) |
| | DYRK4 | Protein kinase domain-containing protein. (634 aa) |
| | ENSGGOP00000048172 | Uncharacterized protein. (482 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (490 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (211 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | ENSGGOP00000045067 | Tudor domain containing 3. (116 aa) |
| | ENSGGOP00000044043 | Uncharacterized protein. (100 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | ENSGGOP00000043662 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa) |
| | ENSGGOP00000042938 | Checkpoint protein; Belongs to the HUS1 family. (273 aa) |
| | RFC2 | Replication factor C subunit 2. (354 aa) |
| | ENSGGOP00000042130 | Uncharacterized protein. (112 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1058 aa) |
| | ENSGGOP00000041523 | Uncharacterized protein. (222 aa) |
| | ENSGGOP00000040711 | ATR interacting protein. (799 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | ENSGGOP00000039430 | MDM2 proto-oncogene. (501 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | ENSGGOP00000038520 | Ubiquitin-like domain-containing protein. (187 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | ENSGGOP00000037665 | TFIID_20kDa domain-containing protein. (213 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | RBBP8 | CtIP_N domain-containing protein. (896 aa) |
| | ENSGGOP00000036466 | Checkpoint kinase 2. (529 aa) |
| | ENSGGOP00000034513 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSGGOP00000034396 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (592 aa) |
| | ENSGGOP00000033975 | Uncharacterized protein. (851 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1927 aa) |
| | CSNK2A1 | Casein kinase 2 alpha 1; Belongs to the protein kinase superfamily. (391 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (403 aa) |
| | ENSGGOP00000030134 | Peptidyl-prolyl cis-trans isomerase. (155 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | G3SH53_GORGO | TAFII28 domain-containing protein. (198 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (597 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1215 aa) |
| | G3SEP4_GORGO | Ubiquitin-like domain-containing protein. (156 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | G3SCX4_GORGO | TPX2 microtubule nucleation factor. (697 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (720 aa) |
| | WRN | WRN RecQ like helicase. (1435 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1824 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (220 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | G3RXY3_GORGO | TAFII28 domain-containing protein. (183 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | ENSGGOP00000019740 | annotation not available (156 aa) |
| | NUAK2 | NUAK family kinase 2. (672 aa) |
| | G3RSZ4_GORGO | Uncharacterized protein. (595 aa) |
| | G3RQ88_GORGO | Protein kinase domain-containing protein. (187 aa) |
| | LY6G5B | Uncharacterized protein. (298 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | NUAK1 | NUAK family kinase 1. (661 aa) |
