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| | ARHGEF4 | Rho guanine nucleotide exchange factor 4. (690 aa) |
| | OTUD1 | OTU deubiquitinase 1. (481 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2817 aa) |
| | SESTD1 | SEC14 and spectrin domain containing 1. (696 aa) |
| | CLIP3 | CAP-Gly domain containing linker protein 3. (547 aa) |
| | BAG4 | BCL2 associated athanogene 4. (457 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa) |
| | UBC | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (983 aa) |
| | UBE2D3 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | KALRN | Uncharacterized protein. (2986 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (675 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (773 aa) |
| | UBA52 | Ubiquitin-like domain-containing protein. (233 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (215 aa) |
| | G3QPY2_GORGO | Uncharacterized protein. (1173 aa) |
| | G3QQ77_GORGO | Neutral sphingomyelinase activation associated factor. (879 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | G3QRS6_GORGO | FYVE, RhoGEF and PH domain containing 2. (655 aa) |
| | G3QSG6_GORGO | Mitogen-activated protein kinase kinase kinase 20. (780 aa) |
| | MCF2L2 | MCF.2 cell line derived transforming sequence-like 2. (1114 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1031 aa) |
| | G3QT76_GORGO | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | RTN4R | Reticulon 4 receptor. (472 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (762 aa) |
| | WDR31 | WD repeat domain 31. (367 aa) |
| | TRAF2 | TNF receptor-associated factor. (451 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40. (1517 aa) |
| | G3QX09_GORGO | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa) |
| | BIRC8 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX. (236 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (709 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (961 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | G3QYB0_GORGO | TNF receptor superfamily member 10d. (386 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (298 aa) |
| | NGFR | Nerve growth factor receptor. (427 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | MADD | MAP kinase activating death domain. (1647 aa) |
| | XIAP | Uncharacterized protein. (371 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (920 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (725 aa) |
| | RBCK1 | Uncharacterized protein. (204 aa) |
| | CHUK | IKKbetaNEMObind domain-containing protein. (434 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | SPPL2B | Signal peptide peptidase like 2B. (511 aa) |
| | ARHGEF17 | Rho guanine nucleotide exchange factor 17. (2064 aa) |
| | LINGO1 | Leucine rich repeat and Ig domain containing 1. (620 aa) |
| | G3R515_GORGO | Protein kinase C iota. (557 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (440 aa) |
| | ARHGEF38 | DH domain-containing protein. (219 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | TRADD | Death domain-containing protein. (251 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (841 aa) |
| | G3R907_GORGO | T cell lymphoma invasion and metastasis 2. (1725 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (788 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (523 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | ECT2L | Epithelial cell transforming 2 like. (904 aa) |
| | RHOA | Uncharacterized protein. (179 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | SPPL2A | Signal peptide peptidase like 2A. (520 aa) |
| | G3RCS6_GORGO | Trio Rho guanine nucleotide exchange factor. (2867 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (356 aa) |
| | G3RDU1_GORGO | MCF.2 cell line derived transforming sequence like. (1137 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1591 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (948 aa) |
| | G3RI71_GORGO | NACHT domain-containing protein. (1127 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | TGM6 | Transglutaminase 6. (703 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (859 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (712 aa) |
| | RTN4 | Reticulon. (1192 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | ENSGGOP00000019740 | annotation not available (156 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | G3RVX1_GORGO | Uncharacterized protein. (547 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (387 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa) |
| | G3RYA7_GORGO | Uncharacterized protein. (382 aa) |
| | G3S0J3_GORGO | DUF4203 domain-containing protein. (106 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | ECT2 | Epithelial cell transforming 2. (914 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (599 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | G3S4X5_GORGO | MAGE family member D1. (834 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) |
| | G3SC71_GORGO | Uncharacterized protein. (420 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (560 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1562 aa) |
| | G3SDL1_GORGO | Uncharacterized protein. (434 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 35. (479 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | G3SEP4_GORGO | Ubiquitin-like domain-containing protein. (156 aa) |
| | CLIP4 | CAP-Gly domain containing linker protein family member 4. (705 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1063 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | FAS | Fas cell surface death receptor. (340 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19. (796 aa) |
| | G3SHM7_GORGO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (210 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | OTUD7B | OTU deubiquitinase 7B. (843 aa) |
| | SPPL2C | Signal peptide peptidase like 2C. (684 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (709 aa) |
| | ENSGGOP00000028898 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (195 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (803 aa) |
| | ENSGGOP00000030202 | Uncharacterized protein. (279 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (871 aa) |
| | ENSGGOP00000031106 | WD_REPEATS_REGION domain-containing protein. (321 aa) |
| | TAX1BP1 | Tax1 binding protein 1. (779 aa) |
| | BEX3 | Brain expressed X-linked 3. (121 aa) |
| | ENSGGOP00000032522 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (203 aa) |
| | ENSGGOP00000032596 | CCHC NOA-type domain-containing protein. (417 aa) |
| | ENSGGOP00000032650 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | ENSGGOP00000032772 | Uncharacterized protein. (104 aa) |
| | ENSGGOP00000033404 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | ENSGGOP00000034513 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ITSN1 | Intersectin 1. (1721 aa) |
| | OPTN | Optineurin. (577 aa) |
| | ENSGGOP00000035952 | TNF receptor-associated factor. (485 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | PREX1 | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1658 aa) |
| | ARHGEF39 | Rho guanine nucleotide exchange factor 39. (335 aa) |
| | ENSGGOP00000037890 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8820 aa) |
| | ENSGGOP00000038520 | Ubiquitin-like domain-containing protein. (187 aa) |
| | MAPKAPK2 | Protein kinase domain-containing protein. (374 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1001 aa) |
| | ENSGGOP00000039359 | PA domain-containing protein. (463 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | ENSGGOP00000040427 | Rho GDP dissociation inhibitor alpha. (235 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1237 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33. (870 aa) |
| | UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1277 aa) |
| | NAIP | Uncharacterized protein. (198 aa) |
| | ENSGGOP00000042571 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (92 aa) |
| | ULK2 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1036 aa) |
| | SMPD3 | Uncharacterized protein. (535 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3. (558 aa) |
| | APH1B | Aph-1 homolog B, gamma-secretase subunit. (257 aa) |
| | ENSGGOP00000045153 | Mindbomb E3 ubiquitin protein ligase 2. (979 aa) |
| | OMG | Oligodendrocyte myelin glycoprotein. (440 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (468 aa) |
| | G3RF33_GORGO | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | ENSGGOP00000047272 | FYVE, RhoGEF and PH domain containing 4. (856 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | PLEKHG2 | Pleckstrin homology and RhoGEF domain containing G2. (1386 aa) |
| | MAG | Myelin associated glycoprotein. (626 aa) |
| | NCSTN | Nicastrin. (721 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1504 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10. (1369 aa) |
| | UBE2D4 | Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | ENSGGOP00000050590 | Uncharacterized protein. (258 aa) |
| | ENSGGOP00000050852 | annotation not available (362 aa) |
| | ENSGGOP00000051279 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (130 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | ARHGEF9 | Cdc42 guanine nucleotide exchange factor 9. (587 aa) |
| | ENSGGOP00000052157 | annotation not available (92 aa) |
