(46 nodes) RHOH GTPase cycle network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPATA5	Spermatogenesis associated 5. (893 aa)
	G3QGN8_GORGO	Tyrosine-protein kinase. (599 aa)
	PAK1	Non-specific serine/threonine protein kinase. (554 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	NIPSNAP1	Nipsnap homolog 1. (284 aa)
	ROCK2	Uncharacterized protein; Belongs to the protein kinase superfamily. (460 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	TFRC	Transferrin receptor. (760 aa)
	OSBPL11	Oxysterol-binding protein; Belongs to the OSBP family. (747 aa)
	SLC1A5	Amino acid transporter. (541 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (201 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (217 aa)
	PAK4	Non-specific serine/threonine protein kinase. (591 aa)
	JUP	Junction plakoglobin. (745 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	FAM91A1	Family with sequence similarity 91 member A1. (839 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	NSFL1C	NSFL1 cofactor. (372 aa)
	G3RCP9_GORGO	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1403 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1267 aa)
	G3RMA0_GORGO	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	VAMP3	Vesicle associated membrane protein 3. (100 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (753 aa)
	RALGAPA1	Ral GTPase activating protein catalytic alpha subunit 1. (2495 aa)
	TMEM59	Transmembrane protein 59. (324 aa)
	G3S718_GORGO	Uncharacterized protein. (276 aa)
	G3SK28_GORGO	Uncharacterized protein. (356 aa)
	ENSGGOP00000028985	UBX domain-containing protein. (110 aa)
	UBXN2B	Uncharacterized protein. (331 aa)
	ENSGGOP00000030839	Uncharacterized protein. (686 aa)
	LCK	Tyrosine-protein kinase. (524 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	NIPSNAP2	Nipsnap homolog 2. (259 aa)
	ENSGGOP00000039174	Uncharacterized protein. (417 aa)
	ENSGGOP00000040104	Anion exchange protein. (1259 aa)
	ENSGGOP00000040139	Uncharacterized protein. (86 aa)
	ENSGGOP00000040427	Rho GDP dissociation inhibitor alpha. (235 aa)
	ENSGGOP00000045477	Non-specific serine/threonine protein kinase. (530 aa)
	WDR11	WD repeat domain 11. (1224 aa)
	DBN1	Drebrin 1. (743 aa)
	STOM	Stomatin. (288 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGDIB	ARHGDIG	ENSGGOP00000009163	ENSGGOP00000009516	Rho GDP dissociation inhibitor beta.	Rho GDP dissociation inhibitor gamma.	0.916
ARHGDIG	ARHGDIB	ENSGGOP00000009516	ENSGGOP00000009163	Rho GDP dissociation inhibitor gamma.	Rho GDP dissociation inhibitor beta.	0.916
CAV1	CSK	ENSGGOP00000022437	ENSGGOP00000010878	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.417
CAV1	JUP	ENSGGOP00000022437	ENSGGOP00000009860	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Junction plakoglobin.	0.442
CAV1	LAMTOR1	ENSGGOP00000022437	ENSGGOP00000012187	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.405
CAV1	LCK	ENSGGOP00000022437	ENSGGOP00000032008	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.401
CAV1	TFRC	ENSGGOP00000022437	ENSGGOP00000007085	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Transferrin receptor.	0.507
CSK	CAV1	ENSGGOP00000010878	ENSGGOP00000022437	Tyrosine-protein kinase.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.417
CSK	G3QGN8_GORGO	ENSGGOP00000010878	ENSGGOP00000001498	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.465
CSK	JUP	ENSGGOP00000010878	ENSGGOP00000009860	Tyrosine-protein kinase.	Junction plakoglobin.	0.433
CSK	LCK	ENSGGOP00000010878	ENSGGOP00000032008	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.838
CSK	SPATA5	ENSGGOP00000010878	ENSGGOP00000000582	Tyrosine-protein kinase.	Spermatogenesis associated 5.	0.401
CSK	SPATA5L1	ENSGGOP00000010878	ENSGGOP00000022563	Tyrosine-protein kinase.	Spermatogenesis associated 5 like 1.	0.401
CSK	VCP	ENSGGOP00000010878	ENSGGOP00000003146	Tyrosine-protein kinase.	Valosin containing protein; Belongs to the AAA ATPase family.	0.428
ENSGGOP00000028985	G3RCP9_GORGO	ENSGGOP00000028985	ENSGGOP00000013283	UBX domain-containing protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.426
ENSGGOP00000028985	LAMTOR1	ENSGGOP00000028985	ENSGGOP00000012187	UBX domain-containing protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.402
ENSGGOP00000028985	SPATA5	ENSGGOP00000028985	ENSGGOP00000000582	UBX domain-containing protein.	Spermatogenesis associated 5.	0.718
ENSGGOP00000028985	SPATA5L1	ENSGGOP00000028985	ENSGGOP00000022563	UBX domain-containing protein.	Spermatogenesis associated 5 like 1.	0.718
ENSGGOP00000028985	VCP	ENSGGOP00000028985	ENSGGOP00000003146	UBX domain-containing protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.969
ENSGGOP00000030839	RALGAPA1	ENSGGOP00000030839	ENSGGOP00000023273	Uncharacterized protein.	Ral GTPase activating protein catalytic alpha subunit 1.	0.547