STRINGSTRING
DLL1 DLL1 EGF EGF UBC UBC PSEN1 PSEN1 NOTCH3 NOTCH3 PSEN2 PSEN2 WWP2 WWP2 YBX1 YBX1 G3QQC0_GORGO G3QQC0_GORGO G3QXA1_GORGO G3QXA1_GORGO RPS27A RPS27A G3R524_GORGO G3R524_GORGO MIB1 MIB1 PSENEN PSENEN APH1A APH1A G3RT71_GORGO G3RT71_GORGO ENSGGOP00000019740 ENSGGOP00000019740 JAG1 JAG1 G3S2R7_GORGO G3S2R7_GORGO NEURL1 NEURL1 G3S8E4_GORGO G3S8E4_GORGO G3SEP4_GORGO G3SEP4_GORGO DLL4 DLL4 ENSGGOP00000030777 ENSGGOP00000030777 ENSGGOP00000038520 ENSGGOP00000038520 EGFR EGFR APH1B APH1B ENSGGOP00000045153 ENSGGOP00000045153 NCSTN NCSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1183 aa)
UBCPolyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (315 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (376 aa)
NOTCH3Notch receptor 3. (2317 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
YBX1Y-box binding protein 1. (324 aa)
G3QQC0_GORGOUncharacterized protein. (315 aa)
G3QXA1_GORGODelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1199 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
G3R524_GORGOADAM metallopeptidase domain 10. (705 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
G3RT71_GORGOCSD_1 domain-containing protein. (318 aa)
ENSGGOP00000019740annotation not available (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
G3S2R7_GORGOCSP domain-containing protein. (280 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
G3S8E4_GORGOCSP domain-containing protein. (314 aa)
G3SEP4_GORGOUbiquitin-like domain-containing protein. (156 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ENSGGOP00000030777Transforming acidic coiled-coil containing protein 3. (832 aa)
ENSGGOP00000038520Ubiquitin-like domain-containing protein. (187 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ENSGGOP00000045153Mindbomb E3 ubiquitin protein ligase 2. (979 aa)
NCSTNNicastrin. (721 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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