47 items (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	G3QVM0_GORGO	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (210 aa)
	KDM3A	Lysine demethylase 3A. (1321 aa)
	TBL1X	Transducin beta like 1 X-linked. (577 aa)
	RXRB	Retinoid X receptor beta. (537 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (868 aa)
	FASN	Fatty acid synthase. (2500 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (445 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	PLTP	Phospholipid transfer protein. (493 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (838 aa)
	KDM4A	Uncharacterized protein. (1064 aa)
	ARL4C	ADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa)
	ENSGGOP00000023934	Uncharacterized protein. (129 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (522 aa)
	G3S905_GORGO	Uncharacterized protein. (134 aa)
	APOC2	Uncharacterized protein. (178 aa)
	APOC1A	Truncated apolipoprotein C-I, acidic form; Belongs to the apolipoprotein C1 family. (83 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	ABCG1	ABC transporter domain-containing protein. (810 aa)
	ENSGGOP00000033992	Uncharacterized protein. (200 aa)
	ENSGGOP00000034599	Uncharacterized protein. (212 aa)
	APOD	Apolipoprotein D. (215 aa)
	EP300	E1A binding protein p300. (2416 aa)
	TNRC6B	Trinucleotide repeat containing adaptor 6B. (1833 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (453 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (650 aa)
	ENSGGOP00000038823	Nuclear receptor corepressor 1. (2386 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (673 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	G3QH29_GORGO	G protein pathway suppressor 2. (327 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
	ANGPTL3	Angiopoietin like 3. (460 aa)
	FABP6	Fatty acid binding protein 6. (177 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	NRIP1	Nuclear receptor interacting protein 1. (1158 aa)
	MOV10	Mov10 RISC complex RNA helicase. (1005 aa)
	ENSGGOP00000043083	Nuclear receptor corepressor 2. (2519 aa)
	RXRA	Retinoid X receptor alpha. (463 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOC1A	ENSGGOP00000031163	ENSGGOP00000030983	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein C-I, acidic form; Belongs to the apolipoprotein C1 family.	0.596
ABCA1	APOC2	ENSGGOP00000031163	ENSGGOP00000030270	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.468
ABCA1	APOE	ENSGGOP00000031163	ENSGGOP00000006232	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.825
ABCA1	CETP	ENSGGOP00000031163	ENSGGOP00000001567	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.681
ABCA1	FASN	ENSGGOP00000031163	ENSGGOP00000011384	ATP binding cassette subfamily A member 1.	Fatty acid synthase.	0.484
ABCA1	MYLIP	ENSGGOP00000031163	ENSGGOP00000012735	ATP binding cassette subfamily A member 1.	Myosin regulatory light chain interacting protein.	0.621
ABCA1	NR1H2	ENSGGOP00000031163	ENSGGOP00000005489	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.969
ABCA1	NR1H3	ENSGGOP00000031163	ENSGGOP00000008392	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.831
ABCA1	PLTP	ENSGGOP00000031163	ENSGGOP00000015557	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.664
ABCA1	RXRA	ENSGGOP00000031163	ENSGGOP00000041308	ATP binding cassette subfamily A member 1.	Retinoid X receptor alpha.	0.912
ABCA1	RXRB	ENSGGOP00000031163	ENSGGOP00000009599	ATP binding cassette subfamily A member 1.	Retinoid X receptor beta.	0.440
ABCA1	SREBF1	ENSGGOP00000031163	ENSGGOP00000050798	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 1.	0.675
ABCG1	ABCG5	ENSGGOP00000032150	ENSGGOP00000000611	ABC transporter domain-containing protein.	ATP binding cassette subfamily G member 5.	0.835
ABCG1	APOE	ENSGGOP00000032150	ENSGGOP00000006232	ABC transporter domain-containing protein.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.674
ABCG1	CETP	ENSGGOP00000032150	ENSGGOP00000001567	ABC transporter domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.624
ABCG1	G3QH29_GORGO	ENSGGOP00000032150	ENSGGOP00000001647	ABC transporter domain-containing protein.	G protein pathway suppressor 2.	0.428
ABCG1	G3S905_GORGO	ENSGGOP00000032150	ENSGGOP00000024569	ABC transporter domain-containing protein.	Uncharacterized protein.	0.428
ABCG1	MYLIP	ENSGGOP00000032150	ENSGGOP00000012735	ABC transporter domain-containing protein.	Myosin regulatory light chain interacting protein.	0.568
ABCG1	NR1H2	ENSGGOP00000032150	ENSGGOP00000005489	ABC transporter domain-containing protein.	Nuclear receptor subfamily 1 group H member 2.	0.695
ABCG1	NR1H3	ENSGGOP00000032150	ENSGGOP00000008392	ABC transporter domain-containing protein.	Nuclear receptor subfamily 1 group H member 3.	0.766