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CD4 CD4 DAPK1 DAPK1 CD46 CD46 BCL2 BCL2 BECN1 BECN1 UVRAG UVRAG TLR2 TLR2 MTMR14 MTMR14 MYD88 MYD88 TRAF6 TRAF6 IFNG IFNG MTOR MTOR NOD2 NOD2 VDAC1 VDAC1 BAG3 BAG3 GOPC GOPC ATG16L1 ATG16L1 ATG5 ATG5 TSPAN8 TSPAN8 ATG12 ATG12 IRGM IRGM TLR7 TLR7 TLR4 TLR4 NOD1 NOD1 WIPI2 WIPI2 IRGC IRGC CD40 CD40 HMGB1 HMGB1 TLR3 TLR3 WIPI1 WIPI1 CD40LG CD40LG ATG101 ATG101 NBR1 NBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD4CD4 molecule. (458 aa)
DAPK1Death associated protein kinase 1. (1397 aa)
CD46CD46 molecule. (399 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BECN1Beclin 1. (450 aa)
UVRAGUV radiation resistance associated. (699 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
MTMR14Myotubularin related protein 14. (650 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
VDAC1Voltage dependent anion channel 1. (289 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
GOPCPDZ domain-containing protein. (462 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TSPAN8Tetraspanin. (237 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
IRGMImmunity related GTPase M. (181 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (454 aa)
IRGCImmunity related GTPase cinema. (463 aa)
CD40CD40 molecule. (277 aa)
HMGB1Uncharacterized protein. (215 aa)
TLR3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (904 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (447 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ATG101Autophagy related 101. (218 aa)
NBR1NBR1 autophagy cargo receptor. (984 aa)
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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